A 3D bioprinted in situ conjugated-co -fabricated scaffold for potential bone tissue engineering applications

2018 ◽  
Vol 106 (5) ◽  
pp. 1311-1321 ◽  
Author(s):  
Mduduzi N. Sithole ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
Thashree Marimuthu ◽  
Yahya E. Choonara ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

In Situ Collagen Polymerization of Layered Cell-Seeded Electrospun Scaffolds for Bone Tissue Engineering Applications

2010 ◽  
Vol 16 (5) ◽  
pp. 1095-1105 ◽  
Author(s):  
Seth D. McCullen ◽  
Philip R. Miller ◽  
Shaun D. Gittard ◽  
Russell E. Gorga ◽  
Behnam Pourdeyhimi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Electrospun Scaffolds

scholarly journals Responsive and in situ-forming chitosan scaffolds for bone tissue engineering applications: an overview of the last decade

2010 ◽  
Vol 20 (9) ◽  
pp. 1638-1645 ◽  
Author(s):  
Ana M. Martins ◽  
Catarina M. Alves ◽  
F. Kurtis Kasper ◽  
Antonios G. Mikos ◽  
Rui L. Reis
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
In Situ Forming ◽  
Chitosan Scaffolds

In situ collagen polymerization of layered cell-seeded electrospun scaffolds for bone tissue engineering applications

2010 ◽  
pp. 110306233140095 ◽  
Author(s):  
Seth McCullen ◽  
Philip Miller ◽  
Shaun Gittard ◽  
Behnam Pourdeyhimi ◽  
Russell Gorga ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Electrospun Scaffolds

scholarly journals Natural origin scaffolds with in situ pore forming capability for bone tissue engineering applications

2008 ◽  
Vol 4 (6) ◽  
pp. 1637-1645 ◽  
Author(s):  
Ana M. Martins ◽  
Marina I. Santos ◽  
Helena S. Azevedo ◽  
Patricia B. Malafaya ◽  
Rui L. Reis
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Natural Origin

scholarly journals 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 287
Author(s):  
Ye Lin Park ◽  
Kiwon Park ◽  
Jae Min Cha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Critical Size ◽  
Current Knowledge ◽  
3D Bioprinting ◽  
The Past ◽  
Regeneration Processes

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

scholarly journals A Proposed Fabrication Method of Novel PCL-GEL-HAp Nanocomposite Scaffolds for Bone Tissue Engineering Applications

2010 ◽  
Vol 19 (4) ◽  
pp. 096369351001900 ◽  
Author(s):  
A. Hamlekhan ◽  
M. Mozafari ◽  
N. Nezafati ◽  
M. Azami ◽  
H. Hadipour
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Test ◽  
Fibroblast Cell ◽  
Mouse Fibroblast ◽  
Fabrication Method ◽  
Engineering Applications ◽  
Poly Caprolactone

In this study, poly(∊-caprolactone) (PCL), gelatin (GEL) and nanocrystalline hydroxyapatite (HAp) was applied to fabricate novel PCL-GEL-HAp nanaocomposite scaffolds through a new fabrication method. With the aim of finding the best fabrication method, after testing different methods and solvents, the best method and solvents were found, and the nanocomposites were prepared through layer solvent casting combined with freeze-drying. Acetone and distillated water were used as the PCL and GEL solvents, respectively. The mechanical test showed that the increasing of the PCL weight through the scaffolds caused the improvement of the final nanocomposite mechanical behavior due to the increasing of the ultimate stress, stiffness and elastic modulus (8 MPa for 0% wt PCL to 23.5 MPa for 50% wt PCL). The biomineralization investigation of the scaffolds revealed the formation of bone-like apatite layers after immersion in simulated body fluid (SBF). In addition, the in vitro cytotoxity of the scaffolds using L929 mouse fibroblast cell line (ATCC) indicated no sign of toxicity. These results indicated that the fabricated scaffold possesses the prerequisites for bone tissue engineering applications.

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