Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings

2017 ◽  
Vol 105 (12) ◽  
pp. 3360-3368 ◽  
Author(s):  
Julia Koehler ◽  
Leonie Verheyen ◽  
Sarah Hedtrich ◽  
Ferdinand P. Brandl ◽  
Achim M. Goepferich
Keyword(s):  
Ethylene Glycol ◽  
Wound Dressings ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Potential Use

S-Nitrosoglutathione incorporated in poly(ethylene glycol) matrix: potential use for topical nitric oxide delivery

Nitric Oxide ◽  
2004 ◽  
Vol 11 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Amedea Barozzi Seabra ◽  
Gabriela Freitas Pereira de Souza ◽  
Lilian Lúcia da Rocha ◽  
Marcos Nogueira Eberlin ◽  
Marcelo Ganzarolli de Oliveira
Keyword(s):  
Nitric Oxide ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Matrix Potential ◽  
Poly Ethylene ◽  
Nitric Oxide Delivery ◽  
Potential Use

scholarly journals Effect of Molecular Weight on Gelling and Viscoelastic Properties of Poly(caprolactone)–b-Poly(ethylene glycol)–b-Poly(caprolactone) (PCL–PEG–PCL) Hydrogels

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2372
Author(s):  
Noam Y. Steinman ◽  
Noam Y. Bentolila ◽  
Abraham J. Domb
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Mechanical Strength ◽  
High Viscosity ◽  
Poly Ethylene Glycol ◽  
Simple Modification ◽  
Poly Ethylene ◽  
Poly Caprolactone ◽  
Injectable Fillers ◽  
Potential Use

Hydrogels based on poly(caprolactone)–b-poly(ethylene glycol)–b-poly(caprolactone) (PCL–PEG–PCL) have been evaluated extensively as potential injectable fillers or depots for controlled release of drugs. Common drawbacks of these copolymer systems include instability of aqueous solutions and low mechanical strength of gels, issues which are commonly overcome by adding pendant groups to the end of the copolymer chains. Here, a systematic study of the effects of increasing polymer molecular weight (MW) is presented, utilizing PEG blocks of MW 2, 4 or 8 kDa. Triblock copolymers were prepared by the ring-opening polymerization of Ɛ-caprolactone by PEG. Copolymers prepared with PEG MW 2 kDa did not form hydrogels at any copolymer molecular weight. Copolymers prepared with PEG MW 4 kDa formed gels at MW between 11 and 13.5 kDa, and copolymers prepared with PEG MW 8 kDa formed gels at MW between 16 and 18 kDa. Copolymers with PEG block 8 kDa formed hydrogels with high viscosity (17,000 Pa·s) and mechanical strength (G′ = 14,000 Pa). The increased gel strength afforded by increased molecular weight represents a simple modification of the reactants used in the reaction feed without added synthetic or purification steps. Shear-thinning of PCL-PEG-PCL triblock copolymer hydrogels allowed for injection through a standard 23G syringe, allowing for potential use as dermal fillers or drug delivery depots.

scholarly journals Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

2020 ◽  
Vol 9 (3) ◽  
pp. 115-123
Author(s):  
Beata Kaczmarek ◽  
Olha Mazur ◽  
Oliwia Miłek ◽  
Marta Michalska-Sionkowska ◽  
Anna M. Osyczka ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Tannic Acid ◽  
Wound Dressings ◽  
Future Application ◽  
Mechanical Parameters ◽  
Poly Ethylene Glycol ◽  
Affect Cell Viability ◽  
Marrow Mesenchymal Stem Cells ◽  
Potential Applications ◽  
Poly Ethylene

Abstract The interests in the biomedical impact of tannic acid (TA) targeting production of various types of biomaterials, such as digital microfluids, chemical sensors, wound dressings, or bioimplants constantly increase. Despite the significant disadvantage of materials obtained from natural-based compounds and their low stability and fragility, therefore, there is an imperative need to improve materials properties by addition of stabilizing formulas. In this study, we performed assessments of thin films over TA proposed as a cross-linker to be used in combination with polymeric matrix based on chitosan (CTS), i.e. CTS/TA at 80:20 or CTS/TA at 50:50 and poly(ethylene glycol) (PEG) at the concentration of 10% or 20%. We evaluated their mechanical parameters as well as the cytotoxicity assay for human bone marrow mesenchymal stem cells, human melanotic melanoma (MNT-1), and human osteosarcoma (Saos-2). The results revealed significant differences in dose-dependent of PEG regarding the maximum tensile strength (σmax) or impact on the metabolic activity of tissue culture plastic. We observed that PEG improved mechanical parameters prominently, decreased the hemolysis rate, and did not affect cell viability negatively. Enclosed data, confirmed also by our previous reports, will undoubtedly pave the path for the future application of tannic acid-based biomaterials to treat wound healing.

PIEZOELECTRIC PROPERTIES OF POLY(3-HYDROXYBUTYRATE-CO-3-HEDROXYBUTYRATE)-CO-POLY(ETHYLENE GLYCOL) PRODUCED BY CONTROLLED MICROBIOLOGICAL BIOSYNTHESIS

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Anton Bonartsev ◽  
Vera Voinova ◽  
Elizaveta Akoulina ◽  
Andrey Dudun ◽  
Irina Zharkova ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Piezoelectric Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Thermosensitives hydrogels based on poly (ethylene glycol): I. Synthesis, characterization and release

2007 ◽  
Vol 32 (5) ◽  
pp. 431-446 ◽  
Author(s):  
Tahar Bartil ◽  
Mahmoud Bounekhel ◽  
Cedric Calberg ◽  
Robert Jerome
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Quantifying Heart Valve Interstitial Cell Contractile State Using Highly Tunable Poly(Ethylene Glycol) Hydrogels

2019 ◽  
Author(s):  
Alex Khang ◽  
Andrea Gonzalez Rodriguez ◽  
Megan E. Schroeder ◽  
Jacob Sansom ◽  
Emma Lejeune ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Heart Valve ◽  
Interstitial Cell ◽  
Poly Ethylene Glycol ◽  
Contractile State ◽  
Poly Ethylene
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