scholarly journals Extracellular matrix elasticity and topography: Material-based cues that affect cell function via conserved mechanisms

2014 ◽  
Vol 103 (3) ◽  
pp. 1246-1258 ◽  
Author(s):  
Isaac A. Janson ◽  
Andrew J. Putnam
Keyword(s):  
Extracellular Matrix ◽  
Cell Function ◽  
Matrix Elasticity

Cellular modulation by the elasticity of biomaterials

2016 ◽  
Vol 4 (1) ◽  
pp. 9-26 ◽  
Author(s):  
Fengxuan Han ◽  
Caihong Zhu ◽  
Qianping Guo ◽  
Huilin Yang ◽  
Bin Li
Keyword(s):  
Extracellular Matrix ◽  
Cell Fate ◽  
Molecular Mechanisms ◽  
Matrix Elasticity ◽  
Recent Advances

The elasticity of the extracellular matrix has been increasingly recognized as a dominating factor of cell fate and activities. This review provides an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of a variety of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as the pathophysiological implications.

scholarly journals Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment

2018 ◽  
Vol 9 ◽  
Author(s):  
Gorjana Rackov ◽  
Noemi Garcia-Romero ◽  
Susana Esteban-Rubio ◽  
Josefa Carrión-Navarro ◽  
Cristobal Belda-Iniesta ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Function

scholarly journals BIOENERGY ASPECTS OF FUNCTIONING OF VENOUS WALL COMPONENTS (DEMONSTRATION MATERIALS OF STUDENTS AND YOUNG SCIENTISTS)

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Mykhailo Lebedyuk ◽  
Vasily Bocharov ◽  
Veronika Bocharova ◽  
Ivanna Zarychniak ◽  
Аnastasia Kovalenok
Keyword(s):  
Extracellular Matrix ◽  
Cell Function ◽  
Vascular Wall ◽  
Vascular Component ◽  
The Subject ◽  
Wall Components ◽  
Venous Wall

The subject of the study – the wall of the venous vessels of the skin. The purpose of the work is to provide demonstration and text materials of the significance of bioenergetic mechanisms of vascular wall components. The vascular component is an integral part of the pathogenesis of most dermatoses. At the same time, the bioenergetic aspects of cell function and the extracellular matrix of the vascular wall, especially venous ones, are still insufficiently taken into account, as they are the most vulnerable to inflammatory dermatoses.Key words: vascular wall components, demonstration materials.

Precise Design Strategy Of  Smart Extracellular Matrix Based on CRISPR/Cas9 for Regulating Neural Stem Cell Function

2021 ◽  
Author(s):  
Yuanxin Zhai ◽  
Lingyan Yang ◽  
Wenlong Zheng ◽  
Quanwei Wang ◽  
Zhanchi Zhu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Design Strategy

scholarly journals Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue†

2019 ◽  
Vol 100 (6) ◽  
pp. 1581-1596 ◽  
Author(s):  
Camilla K Hughes ◽  
Samar W Maalouf ◽  
Wan-Sheng Liu ◽  
Joy L Pate
Keyword(s):  
Extracellular Matrix ◽  
Corpus Luteum ◽  
Cell Function ◽  
Immune Cell ◽  
Cell Receptor ◽  
Cytokine Signaling ◽  
Matrix Remodeling ◽  
Proteomic Profiling ◽  
Interferon Tau ◽  
In Pregnancy

Abstract The corpus luteum (CL) is essential for maintenance of pregnancy in all mammals and luteal rescue, which occurs around day 16–19 in the cow, is necessary to maintain luteal progesterone production. Transcriptomic and proteomic profiling were performed to compare the day 17 bovine CL of the estrous cycle and pregnancy. Among mRNA and proteins measured, 140 differentially abundant mRNA and 24 differentially abundant proteins were identified. Pathway analysis was performed using four programs. Modulated pathways included T cell receptor signaling, vascular stability, cytokine signaling, and extracellular matrix remodeling. Two mRNA that were less in pregnancy were regulated by prostaglandin F2A in culture, while two mRNA that were greater in pregnancy were regulated by interferon tau. To identify mRNA that could be critical regulators of luteal fate, the mRNA that were differentially abundant during early pregnancy were compared to mRNA that were differentially abundant during luteal regression. Eight mRNA were common to both datasets, including mRNA related to regulation of steroidogenesis and gene transcription. A subset of differentially abundant mRNA and proteins, including those associated with extracellular matrix functions, were predicted targets of differentially abundant microRNA (miRNA). Integration of miRNA and protein data, using miRPath, revealed pathways such as extracellular matrix–receptor interactions, abundance of glutathione, and cellular metabolism and energy balance. Overall, this study has provided a comprehensive profile of molecular changes in the corpus luteum during maternal recognition of pregnancy and has indicated that some of these functions may be miRNA-regulated.

0433 Reconstruction of bile duct structure in vitro by using extracellular matrix elasticity

2010 ◽  
Vol 2009.22 (0) ◽  
pp. 258
Author(s):  
Tomoya KOMATSU ◽  
Ryo SUDO ◽  
Toshiihro MITAKA ◽  
Mariok IKEDA ◽  
Kazuo TANISHITA
Keyword(s):  
Extracellular Matrix ◽  
Bile Duct ◽  
Matrix Elasticity

scholarly journals Integrins as architects of cell behavior

2016 ◽  
Vol 27 (19) ◽  
pp. 2885-2888 ◽  
Author(s):  
Charles H. Streuli
Keyword(s):  
Extracellular Matrix ◽  
Mammary Gland ◽  
Cell Surface ◽  
Cell Function ◽  
External Environment ◽  
Cell Behavior ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Mammary Gland Differentiation

Integrins are cell surface receptors that bind cells to their physical external environment, linking the extracellular matrix to cell function. They are essential in the biology of all animals. In the late 1980s, we discovered that integrins are required for the ability of breast epithelia to do what they are programmed to do, which is to differentiate and make milk. Since then, integrins have been shown to control most other aspects of phenotype: to stay alive, to divide, and to move about. Integrins also provide part of the mechanism that allows cells to form tissues. Here I discuss how we discovered that integrins control mammary gland differentiation and explore the role of integrins as central architects of other aspects of cell behavior.

scholarly journals Matrix elasticity regulates the optimal cardiac myocyte shape for contractility

2014 ◽  
Vol 306 (11) ◽  
pp. H1525-H1539 ◽  
Author(s):  
Megan L. McCain ◽  
Hongyan Yuan ◽  
Francesco S. Pasqualini ◽  
Patrick H. Campbell ◽  
Kevin Kit Parker
Keyword(s):  
Extracellular Matrix ◽  
Aspect Ratio ◽  
Cardiac Myocyte ◽  
Wall Stress ◽  
Neonatal Rat ◽  
Wall Thickening ◽  
Unknown Parameters ◽  
Matrix Elasticity ◽  
Aspect Ratios ◽  
Cell Shapes

Concentric hypertrophy is characterized by ventricular wall thickening, fibrosis, and decreased myocyte length-to-width aspect ratio. Ventricular thickening is considered compensatory because it reduces wall stress, but the functional consequences of cell shape remodeling in this pathological setting are unknown. We hypothesized that decreases in myocyte aspect ratio allow myocytes to maximize contractility when the extracellular matrix becomes stiffer due to conditions such as fibrosis. To test this, we engineered neonatal rat ventricular myocytes into rectangles mimicking the 2-D profiles of healthy and hypertrophied myocytes on hydrogels with moderate (13 kPa) and high (90 kPa) elastic moduli. Actin alignment was unaffected by matrix elasticity, but sarcomere content was typically higher on stiff gels. Microtubule polymerization was higher on stiff gels, implying increased intracellular elastic modulus. On moderate gels, myocytes with moderate aspect ratios (∼7:1) generated the most peak systolic work compared with other cell shapes. However, on stiffer gels, low aspect ratios (∼2:1) generated the most peak systolic work. To compare the relative contributions of intracellular vs. extracellular elasticity to contractility, we developed an analytical model and used our experimental data to fit unknown parameters. Our model predicted that matrix elasticity dominates over intracellular elasticity, suggesting that the extracellular matrix may potentially be a more effective therapeutic target than microtubules. Our data and model suggest that myocytes with lower aspect ratios have a functional advantage when the elasticity of the extracellular matrix decreases due to conditions such as fibrosis, highlighting the role of the extracellular matrix in cardiac disease.

scholarly journals Effect of the Extracellular Matrix on Pancreatic Endocrine Cell Function and its Biocompatibility in Dogs

2001 ◽  
Vol 10 (4-5) ◽  
pp. 493-498 ◽  
Author(s):  
Kazuya Edamura ◽  
Hisako Ohgawara ◽  
Koko Nasu ◽  
Yukiko Iwami ◽  
Ayako Sato ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Endocrine Cell ◽  
Cell Function ◽  
Pancreatic Endocrine Cell
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