Formation of thermo-sensitive polyelectrolyte complex micelles from two biocompatible graft copolymers for drug delivery

2013 ◽  
Vol 102 (7) ◽  
pp. 2163-2172 ◽  
Author(s):  
Guiying Li ◽  
Yanfeng Meng ◽  
Lei Guo ◽  
Ting Zhang ◽  
Junshen Liu
Keyword(s):  
Drug Delivery ◽  
Polyelectrolyte Complex ◽  
Graft Copolymers ◽  
Complex Micelles

Structural transitions and encapsulation selectivity of thermoresponsive polyelectrolyte complex micelles

2019 ◽  
Vol 7 (41) ◽  
pp. 6438-6448 ◽  
Author(s):  
Sachit Shah ◽  
Lorraine Leon
Keyword(s):  
Drug Delivery ◽  
Polyelectrolyte Complex ◽  
Structural Transitions ◽  
Drug Delivery Applications ◽  
Complex Micelles

Polyelectrolyte complex micelles containing thermoresponsive coronas can exhibit varying morphologies and encapsulate multivalently charged therapeutics for drug delivery applications.

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2553
Author(s):  
Jeffrey M. Ting ◽  
Alexander E. Marras ◽  
Joseph D. Mitchell ◽  
Trinity R. Campagna ◽  
Matthew V. Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Raft Polymerization ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Complex Micelles

A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-block-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure–property relationships centered on poly(ethylene glycol)-block-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-block-poly(l-lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a diameter ~1.5–2× larger when PMPC-PVBTMA was used compared to PEG-PLK and PEG-PVBTMA via SAXS and DLS. In addition, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methacrylic Acid ◽  
Polyelectrolyte Complex ◽  
Core Shell ◽  
Layer By Layer ◽  
Structural Effects

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.

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