Effect of calcium carbonate on hardening, physicochemical properties, and in vitro degradation of injectable calcium phosphate cements

2011 ◽  
Vol 100A (3) ◽  
pp. 712-719 ◽  
Author(s):  
Kemal Sariibrahimoglu ◽  
Sander C. G. Leeuwenburgh ◽  
Joop G. C. Wolke ◽  
Li Yubao ◽  
John A. Jansen
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Physicochemical Properties ◽  
In Vitro Degradation ◽  
Calcium Phosphate Cements

Role of macropore size in the mechanical properties and in vitro degradation of porous calcium phosphate cements

2010 ◽  
Vol 64 (18) ◽  
pp. 2028-2031 ◽  
Author(s):  
Bai Feng ◽  
Meng Guolin ◽  
Yuan Yuan ◽  
Liu Changshen ◽  
Wang Zhen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
In Vitro Degradation ◽  
Calcium Phosphate Cements

Effect of PLGA/lecithin hybrid microspheres and β-tricalcium phosphate granules on the physicochemical properties, in vitro degradation and biocompatibility of calcium phosphate cement

RSC Advances ◽  
2015 ◽  
Vol 5 (59) ◽  
pp. 47749-47756 ◽  
Author(s):  
Tingting Wu ◽  
Haishan Shi ◽  
Jiandong Ye
Keyword(s):  
Calcium Phosphate ◽  
Physicochemical Properties ◽  
Calcium Phosphate Cement ◽  
Tricalcium Phosphate ◽  
In Vitro Degradation ◽  
Cell Affinity

CPC with beta-TCP granules and PLGA/Lec microspheres reveals better degradability and cell affinity along with proper physicochemical properties.

scholarly journals In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations

2020 ◽  
Vol 5 (3) ◽  
pp. 644-658 ◽  
Author(s):  
M.A. Goldberg ◽  
P.A. Krohicheva ◽  
A.S. Fomin ◽  
D.R. Khairutdinova ◽  
O.S. Antonova ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
One Pot ◽  
Calcium Phosphate Cements

scholarly journals Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres

2020 ◽  
Vol 21 (11) ◽  
pp. 3745
Author(s):  
Michiyo Honda ◽  
Yusuke Kawanobe ◽  
Kohei Nagata ◽  
Ken Ishii ◽  
Morio Matsumoto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bacterial Adhesion ◽  
Inflammatory Responses ◽  
Spray Pyrolysis Technique ◽  
Biological Properties ◽  
Histological Evaluation ◽  
Bone Apposition ◽  
Calcium Phosphate Cements

Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Silver-containing tricalcium phosphate (Ag-TCP) microspheres consisting of α/β-TCP phases were synthesized by an ultrasonic spray-pyrolysis technique. The powders prepared were mixed with the setting liquid to fabricate the CPCs. The resulting cements consisting of β-TCP and hydroxyapatite had a porous structure and wash-out resistance. Additionally, silver and calcium ions could be released into the culture medium from Ag-TCP cements for a long time accompanied by the dissolution of TCP. These data showed the bioresorbability of the Ag-TCP cement. In vitro antibacterial evaluation demonstrated that both released and immobilized silver suppressed the growth of bacteria and prevented bacterial adhesion to the surface of CPCs. Furthermore, histological evaluation by implantation of Ag-TCP cements into rabbit tibiae exhibited abundant bone apposition on the cement without inflammatory responses. These results showed that Ag-TCP cement has a good antibacterial property and good biocompatibility. The present Ag-TCP cements are promising for bone tissue engineering and may be used as antibacterial biomaterials.

scholarly journals Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis

2010 ◽  
Vol 105 (3) ◽  
pp. 384-392 ◽  
Author(s):  
Ossama Allam ◽  
Diane Bahuaud ◽  
Sylviane Taché ◽  
Nathalie Naud ◽  
Denis E. Corpet ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Metal Ion ◽  
Control Diet ◽  
Red Meat ◽  
Preneoplastic Lesions ◽  
Increased Risk ◽  
High Calcium

Red meat intake is associated with an increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions, aberrant crypt foci (ACF), in the colon of rats. We have also shown that dietary calcium phosphate inhibits haemin-induced promotion and normalises faecal lipoperoxides and cytotoxicity. Unexpectedly, high-calcium phosphate control diet-fed rats had more preneoplastic lesions in the colon than low-Ca control diet-fed rats. The present study was designed to find a Ca supplementation with no adverse effect, by testing several doses and types of Ca salts. Onein vitrostudy and two short-term studies in rats identified calcium carbonate as the most effective Ca salt to bind haemin vitroand to decrease faecal biomarkers previously associated with increased carcinogenesis: faecal water cytotoxicity and thiobarbituric acid-reactive substances. A long-term carcinogenesis study in dimethylhydrazine-injected rats demonstrated that a diet containing 100 μmol/g calcium carbonate did not promote ACF, in contrast with a previously tested calcium phosphate diet. The results suggest that calcium carbonate, and not calcium phosphate, should be used to reduce haem-associated colorectal cancer risk in meat eaters. They support the concept that the nature of the associated anion to a protective metal ion is important for chemoprevention.

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