Cationic copolymers nanoparticles for nonviral gene vectors: Synthesis, characterization, and application in gene delivery

2010 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Giovanna Gomez d'Ayala ◽  
Anna Calarco ◽  
Mario Malinconico ◽  
Paola Laurienzo ◽  
Orsolina Petillo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Vectors ◽  
Cationic Copolymers

Immobilization of gene vectors on bisphosphonate-mediated gene-eluting metal stents using antibody for localized gene delivery

2011 ◽  
Vol 152 ◽  
pp. e173-e174 ◽  
Author(s):  
Yong Wang ◽  
Mei Yu ◽  
Linhua Zhang ◽  
Cunxian Song ◽  
Ivan S. Alferiev ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Metal Stents ◽  
Gene Vectors

Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors

2016 ◽  
Vol 4 (33) ◽  
pp. 5575-5584 ◽  
Author(s):  
Zheng Huang ◽  
Yi-Mei Zhang ◽  
Qian Cheng ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors

Bolalipids based on lysine or cyclen headgroups were synthesized and their structure–activity relationship as gene delivery vectors was studied.

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

Flexible cyclic siloxane core enhances the transfection efficiency of polyethylenimine-based non-viral gene vectors

2015 ◽  
Vol 3 (42) ◽  
pp. 8250-8267 ◽  
Author(s):  
Cristina M. Uritu ◽  
Manuela Calin ◽  
Stelian S. Maier ◽  
Corneliu Cojocaru ◽  
Alina Nicolescu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Cyclic Siloxane ◽  
Gene Vectors

cD4H–AGE–PEI conjugates, with a favorable balance between hydrophilic and hydrophobic moieties, are promising carriers for gene delivery.

Structure–activity relationship of novel low-generation dendrimers for gene delivery

2018 ◽  
Vol 16 (42) ◽  
pp. 7833-7842 ◽  
Author(s):  
Yong-Guang Gao ◽  
Xiao Lin ◽  
Kai Dang ◽  
Shan-Feng Jiang ◽  
Ye Tian ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Sar Studies ◽  
Structure Activity ◽  
Gene Vectors ◽  
Relationship Of

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.

Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung

2011 ◽  
Vol 154 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Corinna Pfeifer ◽  
Guenther Hasenpusch ◽  
Senta Uezguen ◽  
Manish Kumar Aneja ◽  
Dietrich Reinhardt ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Dry Powder ◽  
Dry Powder Aerosols ◽  
Efficient Gene ◽  
Gene Vectors ◽  
Powder Aerosols

Gemini-Type Tetraphenylethylene Amphiphiles Containing [12]aneN3 and Long Hydrocarbon Chains as Nonviral Gene Vectors and Gene Delivery Monitors

2017 ◽  
Vol 9 (13) ◽  
pp. 11546-11556 ◽  
Author(s):  
Ai-Xiang Ding ◽  
Zheng-Li Tan ◽  
You-Di Shi ◽  
Lin Song ◽  
Bing Gong ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Hydrocarbon Chains ◽  
Gene Vectors

Self-Assembled BolA-like Amphiphilic Peptides as Viral-Mimetic Gene Vectors for Cancer Cell Targeted Gene Delivery

2012 ◽  
Vol 13 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Jing-Xiao Chen ◽  
Xiao-Ding Xu ◽  
Shuo Yang ◽  
Juan Yang ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Cell ◽  
Targeted Gene Delivery ◽  
Amphiphilic Peptides ◽  
Gene Vectors ◽  
Self Assembled

Peptide amphiphiles with multifunctional fragments promoting cellular uptake and endosomal escape as efficient gene vectors

2015 ◽  
Vol 3 (6) ◽  
pp. 1068-1078 ◽  
Author(s):  
Liang Luan ◽  
Qingbin Meng ◽  
Liang Xu ◽  
Zhao Meng ◽  
Husheng Yan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cellular Uptake ◽  
Transfection Efficiency ◽  
Endosomal Escape ◽  
Peptide Amphiphiles ◽  
Gene Delivery Vectors ◽  
Efficient Gene ◽  
Gene Vectors ◽  
Lipofectamine 2000

A series of peptides containing multiple functional fragments were designed as gene-delivery vectors with transfection efficiency comparable to Lipofectamine 2000.

scholarly journals Scaffold-Mediated Gene Delivery for Osteochondral Repair

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 930 ◽  
Author(s):  
Henning Madry ◽  
Jagadeesh Kumar Venkatesan ◽  
Natalia Carballo-Pedrares ◽  
Ana Rey-Rico ◽  
Magali Cucchiarini
Keyword(s):  
Gene Delivery ◽  
Viral Vectors ◽  
Viral Gene ◽  
Therapeutic Gene ◽  
Therapeutic Concept ◽  
Osteochondral Repair ◽  
Gene Vectors ◽  
A Site

Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has recently emerged as an attractive therapeutic concept for osteochondral repair. The goal of this review is to provide an overview of the variety of biomaterials employed as nonviral or viral gene carriers for osteochondral repair approaches both in vitro and in vivo, including hydrogels, solid scaffolds, and hybrid materials. The data show that a site-specific delivery of therapeutic gene vectors in the context of acellular or cellular strategies allows for a spatial and temporal control of osteochondral neotissue composition in vitro. In vivo, implantation of acellular hydrogels loaded with nonviral or viral vectors has been reported to significantly improve osteochondral repair in translational defect models. These advances support the concept of scaffold-mediated gene delivery for osteochondral repair.

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