Hyaluronan-based scaffold forin vivoregeneration of the rat vena cava: Preliminary results in an animal model

2009 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Laura Pandis ◽  
Barbara Zavan ◽  
Giovanni Abatangelo ◽  
Sandro Lepidi ◽  
Roberta Cortivo ◽  
...  
2006 ◽  
Vol 32 (4) ◽  
pp. 411-417 ◽  
Author(s):  
S. Lepidi ◽  
F. Grego ◽  
V. Vindigni ◽  
B. Zavan ◽  
C. Tonello ◽  
...  

1995 ◽  
Vol 78 (5) ◽  
pp. 1882-1888 ◽  
Author(s):  
I. Sayet ◽  
G. Neuilly ◽  
J. Mironneau ◽  
C. Mironneau

Effects of hindlimb suspension, spaceflight, and venous occlusion were examined in isolated strips from rat vena cava by using both [3H]prazosin-binding and contraction responses evoked by norepinephrine. Sensitivity to norepinephrine was decreased without modification of the maximal contractile response. Furthermore, the high K(+)-induced contractions were not affected, suggesting that there was no interference with voltage-dependent Ca2+ channels. The sensitivity of the norepinephrine-induced contraction to prazosin was decreased, and Scatchard analysis of [3H]prazosin binding indicated an increase in the dissociation constant without variation in maximal binding capacity. A similar increase in the dissociation constant was obtained in control rats after pretreatment with 3 microM norepinephrine or 0.1 microM phorbol 12,13-dibutyrate to desensitize the protein kinase C. This effect was completely abolished in the presence of GF-109203X, a selective inhibitor of protein kinase C. Taken together, these data indicate that altered gravity conditions induce a desensitization of alpha 1B-adrenoceptors depending on increased protein kinase C activity. This effect can be mimicked by venous occlusion and may be responsible for reduced contractile responses to norepinephrine.


2012 ◽  
Vol 19 (3) ◽  
pp. 439-449 ◽  
Author(s):  
Pascal Chabrot ◽  
Ahmed Fatimi ◽  
Patrizio Delli Fraine ◽  
Lemlih Ouchchane ◽  
Marie-Mélanie Dauplat ◽  
...  

2004 ◽  
Vol 52 (Suppl 1) ◽  
pp. S112.3-S112
Author(s):  
J. L. Chen ◽  
M. C. Gupta ◽  
P. Moazzaz ◽  
E. C. Shin ◽  
M. N. Gilotra ◽  
...  

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