Biological response to micron- and nanometer-sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

2009 ◽  
Vol 89A (2) ◽  
pp. 390-401 ◽  
Author(s):  
I. Kranz ◽  
J. B. Gonzalez ◽  
I. Dörfel ◽  
M. Gemeinert ◽  
M. Griepentrog ◽  
...  
Keyword(s):  
Biological Response ◽  
Size Distributions ◽  
Hip Joints ◽  
Murine Macrophages ◽  
Artificial Hip ◽  
Artificial Hip Joints ◽  
Wear Products

Biological response to wear debris generated in carbon based composites as potential bearing surfaces for artificial hip joints

2003 ◽  
Vol 67B (2) ◽  
pp. 758-764 ◽  
Author(s):  
G. I. Howling ◽  
H. Sakoda ◽  
A. Antonarulrajah ◽  
H. Marrs ◽  
T. D. Stewart ◽  
...  
Keyword(s):  
Wear Debris ◽  
Biological Response ◽  
Hip Joints ◽  
Artificial Hip ◽  
Artificial Hip Joints ◽  
Carbon Based

A Trial of Numerical Calculation of Wear for Artificial Hip Joints

2010 ◽  
pp. 21-26
Author(s):  
Hirohisa Narita ◽  
Kakeru Harusawa ◽  
Makoto Yagihashi ◽  
Hideo Fujimoto
Keyword(s):  
Numerical Calculation ◽  
Hip Joints ◽  
Artificial Hip ◽  
Artificial Hip Joints

Wear of Historical Polyethylenes in Hip Prostheses. Biomechanical Success and a Biological Failure

2003 ◽  
Vol 13 (2_suppl) ◽  
pp. 17-27 ◽  
Author(s):  
E. Ingham ◽  
J. Fisher ◽  
M.H. Stone
Keyword(s):  
Polyethylene Wear ◽  
Simulation Models ◽  
Hip Joints ◽  
Hip Prostheses ◽  
Artificial Hip ◽  
Cause Of Failure ◽  
Artificial Hip Joints ◽  
Gamma Irradiated ◽  
Biological Simulation

Polyethylene wear debris induced osteolysis is a major cause of failure in artificial hip joints. Sub micrometre size particles are taken up by macrophages which are stimulated to release osteolytic cytokines such as TNFα. This leads to bone resorption, loosening and failure. In vitro cell culture studies have shown particles in the size range 0.1 to 1 micrometre to be at least six times more reactive than larger particles. Studies of historically used gamma irradiated in air polyethylene show increased wear rate with damaged femoral heads and with aged and oxidised polyethylene. The aged and oxidised polyethylene also produced a greater percentage of smaller particles leading to increased osteolytic potential. Combined tribological and biological simulation models have been developed for pre-clinical assessment of osteolytic potential of artificial hip joints.

scholarly journals Biotribology of artificial hip joints

2015 ◽  
Vol 6 (1) ◽  
pp. 77 ◽  
Author(s):  
Francesca Di Puccio
Keyword(s):  
Hip Joints ◽  
Artificial Hip ◽  
Artificial Hip Joints
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