Self‐assembling cyclodextrin based hydrogels for the sustained delivery of hydrophobic drugs

2008 ◽  
Vol 86A (3) ◽  
pp. 736-748 ◽  
Author(s):  
S. Daoud‐Mahammed ◽  
J. L. Grossiord ◽  
T. Bergua ◽  
C. Amiel ◽  
P. Couvreur ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Hydrophobic Drugs ◽  
Self Assembling

scholarly journals Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 744
Author(s):  
Ijeoma F. Uchegbu ◽  
Jan Breznikar ◽  
Alessandra Zaffalon ◽  
Uche Odunze ◽  
Andreas G. Schätzlein
Keyword(s):  
Polymeric Micelles ◽  
Rabbit Model ◽  
Penetration Enhancer ◽  
Hydrophobic Drugs ◽  
Ocular Tissues ◽  
Ocular Penetration ◽  
Self Assembling ◽  
Similar Dose ◽  
Oil In Water ◽  
The Stability

Commercial topical ocular formulations for hydrophobic actives rely on the use of suspensions or oil in water emulsions and neither of these formulation modalities adequately promote drug penetration into ocular tissues. Using the ocular relevant hydrophobic drug, cyclosporine A (CsA), a non-irritant ocular penetration enhancer is showcased, which may be used for the formulation of hydrophobic actives. The activity of this penetration enhancer is demonstrated in a healthy rabbit model. The Molecular Envelope Technology (MET) polymer (N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan), a self-assembling, micelle-forming polymer, was used to formulate CsA into sterile filtered nanoparticulate eye drop formulations and the stability of the formulation tested. Healthy rabbits were dosed with a single dose of a MET–CsA (NM133) 0.05% formulation and ocular tissues analyzed. Optically clear NM133 formulations were prepared containing between 0.01–0.1% w/v CsA and 0.375–0.75% w/v MET polymer. NM133 0.01%, NM133 0.02% and NM133 0.05% were stable for 28 days when stored at refrigeration temperature (5–6 °C) and room temperature (16–23 °C), but there was evidence of evaporation of the formulation at 40 °C. There was no change in drug content when NM133 0.05% was stored for 387 days at 4 °C. On topical dosing to rabbits, corneal, conjunctival and scleral AUC0–24 levels were 25,780 ng.h g−1, 12,046 ng.h g−1 and 5879 ng.h g−1, respectively, with NM133 0.05%. Meanwhile, a similar dose of Restasis 0.05% yielded lower values of 4726 ng.h/g, 4813 ng.h/g and 1729 ng.h/g for the drug corneal, conjunctival and scleral levels, respectively. NM133 thus delivered up to five times more CsA to the ocular surface tissues when compared to Restasis. The MET polymer was non-irritant up to a concentration of 4% w/v. The MET polymer is a non-irritant ocular penetration enhancer that may be used to deliver hydrophobic drugs in optically clear topical ocular formulations.

Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

2014 ◽  
Vol 102 ◽  
pp. 110-116 ◽  
Author(s):  
Laura Mayol ◽  
Marco Biondi ◽  
Luisa Russo ◽  
Birgitte M. Malle ◽  
Khadija Schwach-Abdellaoui ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Sustained Delivery ◽  
Hydrophobic Drugs

Self-assembling systems based on quaternized derivatives of 1,4-diazabicyclo[2.2.2]octane in nutrient broth as antimicrobial agents and carriers for hydrophobic drugs

2015 ◽  
Vol 127 ◽  
pp. 266-273 ◽  
Author(s):  
Tatiana N. Pashirova ◽  
Svetlana S. Lukashenko ◽  
Sergey V. Zakharov ◽  
Alexandra D. Voloshina ◽  
Elena P. Zhiltsova ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Nutrient Broth ◽  
Hydrophobic Drugs ◽  
Self Assembling ◽  
Derivatives Of

Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction

2012 ◽  
Vol 424 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Hai-dong Guo ◽  
Guo-hong Cui ◽  
Jia-jun Yang ◽  
Cun Wang ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Sustained Delivery ◽  
Self Assembling

scholarly journals Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

2015 ◽  
pp. 847 ◽  
Author(s):  
Feng Qiu ◽  
Yongzhu Chen ◽  
Chengkang Tang ◽  
Jie Zhang ◽  
Meng Gong ◽  
...  
Keyword(s):  
Delivery System ◽  
Hydrophobic Drugs ◽  
Self Assembling

Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained delivery of hydrophobic drugs. The case of thymol buccal delivery

2021 ◽  
pp. 51432
Author(s):  
María I. Alvarez Echazú ◽  
María E. Antona ◽  
Oriana Perna ◽  
Christian E. Olivetti ◽  
Gisela S. Alvarez ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Hydrophobic Drugs ◽  
Buccal Delivery ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

scholarly journals Sustained delivery of bioactive TGF-β1 from self-assembling peptide hydrogels induces chondrogenesis of encapsulated bone marrow stromal cells

2013 ◽  
Vol 102 (5) ◽  
pp. 1275-1285 ◽  
Author(s):  
Paul W. Kopesky ◽  
Sangwon Byun ◽  
Eric J. Vanderploeg ◽  
John D. Kisiday ◽  
David D. Frisbie ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Sustained Delivery ◽  
Self Assembling ◽  
Peptide Hydrogels ◽  
Tgf Β1
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