Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained delivery of hydrophobic drugs. The case of thymol buccal delivery

2021 ◽  
pp. 51432
Author(s):  
María I. Alvarez Echazú ◽  
María E. Antona ◽  
Oriana Perna ◽  
Christian E. Olivetti ◽  
Gisela S. Alvarez ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Hydrophobic Drugs ◽  
Buccal Delivery ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

scholarly journals Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

2012 ◽  
Vol 2 (5) ◽  
pp. 439-449 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Amrita Thakur ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Present Status ◽  
Engineering Systems ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

2014 ◽  
Vol 102 ◽  
pp. 110-116 ◽  
Author(s):  
Laura Mayol ◽  
Marco Biondi ◽  
Luisa Russo ◽  
Birgitte M. Malle ◽  
Khadija Schwach-Abdellaoui ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Sustained Delivery ◽  
Hydrophobic Drugs

scholarly journals Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Emilia Szymańska ◽  
Anna Czajkowska-Kośnik ◽  
Katarzyna Winnicka
Keyword(s):  
Drug Release ◽  
Ex Vivo ◽  
Physicochemical Characteristics ◽  
Vaginal Mucosa ◽  
Drug Release Profile ◽  
Modified Chitosan ◽  
Long Term Storage ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
The Impact

The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations. Additionally, the impact of chitosan modification on the ex vivo mucoadhesive performance in contact with porcine vaginal mucosa and on the drug release profile from hydrogels was evaluated. Viscosity and mechanical properties of formulations with unmodified chitosan decreased significantly upon storage regardless of tested conditions as a result of hydrolytic depolymerization. Introduction of ion crosslinker exerted stabilizing effect on physicochemical performance of chitosan hydrogels but only upon storage at refrigerated conditions. Beta-glycerophosphate-modified chitosan formulations preserved organoleptic, rheological behavior, and hydrogel structure up to 3-month storage at 4 ± 2°C. Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.

scholarly journals Facile Preparation of Tunicate-Inspired Chitosan Hydrogel Adhesive with Self-Healing and Antibacterial Properties

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4322
Author(s):  
Xiang He ◽  
Ruyue Liu ◽  
Huiqing Liu ◽  
Ruixiao Wang ◽  
Zhenhao Xi ◽  
...  
Keyword(s):  
Protein A ◽  
Gelation Time ◽  
Antibacterial Properties ◽  
Tissue Adhesive ◽  
Self Healing ◽  
Tissue Adhesion ◽  
E Coli ◽  
Modified Chitosan ◽  
Non Invasive ◽  
Chitosan Hydrogels

In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl3 and TBA via the Schiff-base reaction and the coordination between Fe3+ and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe3+. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe3+. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity against E. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.

scholarly journals Modified Chitosan Hydrogels and Nano Hydrogels for Congo Red Removal from Aqueous System

2021 ◽  
Vol 38 (1) ◽  
pp. 91-117
Author(s):  
Shimaa Khaled ◽  
Abir S. Nasr ◽  
Howida T. Zaky ◽  
Nadia G. Kandile
Keyword(s):  
Congo Red ◽  
Aqueous System ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

Modified Chitosan Hydrogels and Nano Hydrogels for Congo Red Removal from Aqueous System

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
shimaa khaled ◽  
Howaida Zaky ◽  
Abeer Salah Nasr ◽  
nadia hassan
Keyword(s):  
Congo Red ◽  
Aqueous System ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

Self‐assembling cyclodextrin based hydrogels for the sustained delivery of hydrophobic drugs

2008 ◽  
Vol 86A (3) ◽  
pp. 736-748 ◽  
Author(s):  
S. Daoud‐Mahammed ◽  
J. L. Grossiord ◽  
T. Bergua ◽  
C. Amiel ◽  
P. Couvreur ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Hydrophobic Drugs ◽  
Self Assembling

scholarly journals Peptide-Modified Chitosan Hydrogels Accelerate Skin Wound Healing by Promoting Fibroblast Proliferation, Migration, and Secretion

2017 ◽  
Vol 26 (8) ◽  
pp. 1331-1340 ◽  
Author(s):  
Xionglin Chen ◽  
Min Zhang ◽  
Shixuan Chen ◽  
Xueer Wang ◽  
Zhihui Tian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Skin Wound ◽  
Skin Wounds ◽  
Skin Wound Healing ◽  
Promote Cell Proliferation ◽  
Modified Chitosan ◽  
Chitosan Hydrogels ◽  
Positive Controls

Skin wound healing is a complicated process that involves a variety of cells and cytokines. Fibroblasts play an important role in this process and participate in transformation into myofibroblasts, the synthesis of extracellular matrix (ECM) and fibers, and the secretion of a variety of growth factors. This study assessed the effects of peptide Ser-Ile-Lys-Val-Ala-Val (SIKVAV)--modified chitosan hydrogels on skin wound healing. We investigated the capability of peptide SIKVAV to promote cell proliferation and migration, the synthesis of collagen, and the secretion of a variety of growth factors using fibroblasts in vitro. We also treated skin wounds established in mice using peptide SIKVAV-modified chitosan hydrogels. Hematoxylin and eosin staining showed that peptide-modified chitosan hydrogels enhanced the reepithelialization of wounds compared with negative and positive controls. Masson’s trichrome staining demonstrated that more collagen fibers were deposited in the wounds treated with peptide-modified chitosan hydrogels compared with the negative and positive controls. Immunohistochemistry revealed that the peptide-modified chitosan hydrogels promoted angiogenesis in the skin wound. Taken together, these results suggest that peptide SIKVAV-modified chitosan hydrogels may be useful in wound dressing and the treatment of skin wounds.

Sustained delivery by leucine-modified chitosan spray-dried respirable powders

2009 ◽  
Vol 372 (1-2) ◽  
pp. 97-104 ◽  
Author(s):  
Tristan P. Learoyd ◽  
Jane L. Burrows ◽  
Eddie French ◽  
Peter C. Seville
Keyword(s):  
Sustained Delivery ◽  
Modified Chitosan ◽  
Spray Dried
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