Differential regulation of endothelial cell adhesion, spreading, and cytoskeleton on low-density polyethylene by nanotopography and surface chemistry modification induced by argon plasma treatment

2008 ◽  
Vol 84A (3) ◽  
pp. 828-836 ◽  
Author(s):  
S. Tajima ◽  
J.S.F. Chu ◽  
S. Li ◽  
K. Komvopoulos
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Surface Chemistry ◽  
Plasma Treatment ◽  
Argon Plasma ◽  
Differential Regulation ◽  
Low Density Polyethylene ◽  
Low Density ◽  
Surface Chemistry Modification ◽  
Endothelial Cell Adhesion

Modulation of oxidized low-density lipoprotein-induced microvascular dysfunction by nitric oxide

1995 ◽  
Vol 268 (4) ◽  
pp. H1643-H1650 ◽  
Author(s):  
L. Liao ◽  
D. N. Granger
Keyword(s):  
Nitric Oxide ◽  
Mast Cell ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Microvascular Dysfunction ◽  
Mast Cell Degranulation ◽  
Low Density ◽  
No Donors ◽  
Albumin Leakage ◽  
Endothelial Cell Adhesion

The objectives of this study were to determine 1) whether the leukocyte-endothelial cell adhesion in postcapillary venules elicited by copper-oxidized low-density lipoproteins (Cu-LDL) is accompanied by enhanced vascular albumin leakage and mast cell degranulation and 2) whether nitric oxide (NO) donors attenuate the Cu-LDL-induced microvascular dysfunction. Infusion of Cu-LDL, but not normal LDL, caused significant increases in leukocyte rolling, adherence, emigration, mast cell degranulation, and an enhanced albumin leakage in rat mesenteric venules. Treatment with the NO donors sodium nitroprusside and spermine-NO or pretreatment with superoxide dismutase or L-arginine significantly reduced the Cu-LDL-induced leukocyte adherence, emigration, mast cell degranulation, and albumin leakage, whereas spermine and D-arginine had no effect. These results indicate that NO protects the microvasculature against the deleterious effects of oxidized LDL, an effect that may be related to NO's ability to reduce leukocyte-endothelial cell adhesion and/or prevent mast cell degranulation.

scholarly journals Surface chemistry and polymer film thickness effects on endothelial cell adhesion and proliferation

2010 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Dhiman Bhattacharyya ◽  
Hao Xu ◽  
Rajendra R. Deshmukh ◽  
Richard B. Timmons ◽  
Kytai T. Nguyen
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Film Thickness ◽  
Surface Chemistry ◽  
Polymer Film ◽  
Cell Adhesion And Proliferation ◽  
Endothelial Cell Adhesion

Different Cell Responses on Biologically Inspired Nano-coatings for Orthopedic Applications

2009 ◽  
Vol 1209 ◽  
Author(s):  
Lijie Zhang ◽  
Usha D. Hemraz ◽  
Hicham Fenniri ◽  
Thomas J Webster
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Surface Chemistry ◽  
In Vitro Study ◽  
Clinical Problem ◽  
Biologically Inspired ◽  
Age Related ◽  
Orthopedic Applications ◽  
Endothelial Cell Adhesion

AbstractVarious bone defects, caused by trauma, disease or age-related degeneration, represent a crucial clinical problem all over the world. However, traditional implant materials may cause many complications after surgeries, leading to intense patient pain. Thus, the objective of this in vitro study was to develop a biologically inspired coating on conventional titanium with materials that possess biomimetic nanostructured architectures and favorable surface chemistry. Specifically, self-assembled rosette nanotubes (RNTs) functionalized with various osteogenic peptides and amino acids (such as lysine-arginine-serine-arginine (KRSR), arginine-glycine-aspartic acid (RGD) and lysine (K)) were designed as coatings. Results revealed excellent cytocompatibility properties of these RNTs towards enhancing osteoblast (bone forming cell) and endothelial cell adhesion. In particular, KRSR and RGD functionalized RNTs coated on titanium promoted the greatest osteoblast densities when compared to uncoated titanium. In addition, the KRSR functionalized RNTs selectively improved osteoblast adhesion but not endothelial cell adhesion when coated on titanium. From this study, it can be speculated that the biologically inspired nanotubular structure and osteogenic surface chemistry of RNTs altered the surface properties of titanium to transform it into a more favorable environment for orthopedic applications.

Sign in / Sign up

Export Citation Format

Share Document