Architecture control of three-dimensional polymeric scaffolds for soft tissue engineering. I. Establishment and validation of numerical models

2004 ◽  
Vol 71A (1) ◽  
pp. 81-89 ◽  
Author(s):  
Yang Cao ◽  
Malcolm R. Davidson ◽  
Andrea J. O'Connor ◽  
Geoffrey W. Stevens ◽  
Justin J. Cooper-White
Biomaterials ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. 8141-8152 ◽  
Author(s):  
Zhilian Yue ◽  
Feng Wen ◽  
Shujun Gao ◽  
Ming Yi Ang ◽  
Pramoda K. Pallathadka ◽  
...  

2015 ◽  
Vol 68 (9) ◽  
pp. 1409 ◽  
Author(s):  
Justin M. Sirrine ◽  
Allison M. Pekkanen ◽  
Ashley M. Nelson ◽  
Nicholas A. Chartrain ◽  
Christopher B. Williams ◽  
...  

Additive manufacturing, or three-dimensional (3D) printing, has emerged as a viable technique for the production of vascularized tissue engineering scaffolds. In this report, a biocompatible and biodegradable poly(tri(ethylene glycol) adipate) dimethacrylate was synthesized and characterized for suitability in soft-tissue scaffolding applications. The polyester dimethacrylate exhibited highly efficient photocuring, hydrolyzability, and 3D printability in a custom microstereolithography system. The photocured polyester film demonstrated significantly improved cell attachment and viability as compared with controls. These results indicate promise of novel, printable polyesters for 3D patterned, vascularized soft-tissue engineering scaffolds.


Author(s):  
Yang Cao ◽  
Tristan I. Croll ◽  
Justin J. Cooper-White ◽  
Andrea J. O'Connor ◽  
Geoffrey W. Stevens

Author(s):  
Loretta L. del Mercato ◽  
Laura Gioia Passione ◽  
Daniela Izzo ◽  
Rosaria Rinaldi ◽  
Alessandro Sannino ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
pp. 8424-8430

Hydrogels are cross-linked three-dimensional (3D) polymeric network, which can hold the water within its porous structure. They have recently been used in various biomedical applications. In this study, injectable hyaluronic acid (HA) hydrogels were prepared using different concentrations of 1,4-butanediol diglycidyl ether (BDDE) as a crosslinker (1-5% w/w) and investigated their rheological, swelling and injectability properties. The results demonstrated that the rheological characteristics of hydrogels enhanced with increasing crosslinker concentration. The elastic modulus of the hydrogels ranged from 280 Pa to 990 Pa, while the complex viscosities were found between 42 Pa.s and 190 Pa.s at an oscillation frequency of 1 Hz. These results clearly suggest that the injectable HA hydrogels are a potential candidate for various soft tissue engineering applications due to their highly tunable rheological properties.


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