Selective protein adsorption and blood compatibility of hydroxy-carbonate apatites

2004 ◽  
Vol 69A (3) ◽  
pp. 544-551 ◽  
Author(s):  
Shinji Takemoto ◽  
Yuko Kusudo ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Hydroxy Carbonate

Blood Compatibility and Protein Adsorption Characteristics of Sol-Gel Derived Titania

2000 ◽  
Vol 192-195 ◽  
pp. 889-892 ◽  
Author(s):  
S. Takashima ◽  
S. Takemoto ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Sol Gel ◽  
Adsorption Characteristics

scholarly journals The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

2019 ◽  
Vol 94 ◽  
pp. 11-24 ◽  
Author(s):  
John L. Brash ◽  
Thomas A. Horbett ◽  
Robert A. Latour ◽  
Pentti Tengvall
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Adsorption Phenomena

Blood compatibility of surfaces with superlow protein adsorption

Biomaterials ◽  
2008 ◽  
Vol 29 (32) ◽  
pp. 4285-4291 ◽  
Author(s):  
Zheng Zhang ◽  
Min Zhang ◽  
Shengfu Chen ◽  
Thomas A. Horbett ◽  
Buddy D. Ratner ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility

Selective Protein Adsorption Property and Structure of Nano-Crystalline Hydroxy-Carbonate Apatite

2006 ◽  
Vol 309-311 ◽  
pp. 503-506 ◽  
Author(s):  
Satoshi Hayakawa ◽  
K. Ohnishi ◽  
Kanji Tsuru ◽  
Akiyoshi Osaka ◽  
Eiji Fujii ◽  
...  
Keyword(s):  
Surface Charge ◽  
Protein Adsorption ◽  
Adsorption Property ◽  
Considerable Change ◽  
Mas Nmr ◽  
Carbonate Apatite ◽  
Oh Groups ◽  
Carbonate Ions ◽  
Cp Mas Nmr ◽  
Hydroxy Carbonate

The selective protein adsorption property and the local structure around carbonate ions of nanocrystalline hydroxy-carbonate apatite were examined in this study. Considerable change in the selectivity in the adsorption of BSA and β2-MG was observed due to the incorporation of thecarbonate ions in hydroxyapatite lattice. Since the protein adsorption property seems to be related to the surface charge density of hydroxyapatite due to the carbonation, the chemical states of the incorporated carbonate ions were examined by the 31C CP-MAS NMR spectroscopy. At least four peaks assignable to carbonate ions in A-site(OH-) and B-site(PO4 3-) were observed in 13C CP-MAS NMR spectrum. Thus, we must take into consideration that the surface charge distribution and the decrement of polar groups such as OH- groups due to the distribution of carbonate ions in both Aand B-sites of the hydroxyapatite lattice are particularly favorable for β2-MG adsorption rather than for BSA adsorption.

POSS–PU electrospinning nanofibers membrane with enhanced blood compatibility

RSC Advances ◽  
2016 ◽  
Vol 6 (70) ◽  
pp. 65756-65762 ◽  
Author(s):  
Xiaoyan Song ◽  
Tao Li ◽  
Bowen Cheng ◽  
Jinfeng Xing
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Electrospun Fibers ◽  
Adsorption Amount ◽  
Growth Of Bacteria

The addition of POSS results in (a) platelet adsorption amount of electrospun fibers membrane decreased (b) protein adsorption of electrospun fibers membrane decreased (c) the growth of bacteria was inhibited.

Polymers in Nephrology Characteristics and Needs

2002 ◽  
Vol 25 (5) ◽  
pp. 470-479 ◽  
Author(s):  
J. Vienken
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Release Kinetics ◽  
Controlled Drug Release ◽  
Medical Application ◽  
Contact Phase ◽  
Polymer Backbone ◽  
Inflammatory Reactions ◽  
Capillary Membranes ◽  
Extracorporeal Circuits

Polymers employed as biomaterials in nephrology serve for different applications: they form membranes for dialysis and plasmapheresis, are used as materials for dialyser housings and as a potting mass for capillary membranes, they make up tubing-systems for extracorporeal circuits and – in the form of beads – act as parts of adsorber columns for hemoperfusion or immunoadsorption. However, generally speaking, many polymers have not yet been designed for their final application. To date, many polymers are still taken from the chemist's shelf according to their alleged performance properties or to their sterilisability. When used in medical application, polymers must show a high purity. Uncontrolled leaching of oligomers from the polymer backbone or of additives from or during the manufacturing process must be avoided. Blood and other body fluids are extremely effective in extracting any loosely bound polymers. During long-term application, e.g. in patients suffering from chronic diseases, these effects may lead to an accumulation of these compounds in circulating blood, tissue, or joints. Consequently, polymers should show an excellent biostability and not degrade during their ageing process. The amount of extractable material should be kept low in order to avoid inflammatory reactions. Polymers must have high blood compatibility in terms of minimized cell-and complement activation. Polymers for medical application should at best be able to stand high temperatures in order to survive steam sterilisation. If this is impossible, their release kinetics for residual quantities of sterilizing agents should be fast. Finally, protein adsorption should appear under controlled conditions, otherwise a reduced performance through protein adsorption will take place. Further, the uncontrolled activation of biochemical cascades, such as the coagulation, complement or contact phase cascade, following blood/material contact must be minimized. A final aspect has been recently made responsible for adverse patients reactions, the interaction between polymers and medicinal drugs. This drug/material interaction must be low, at best zero, apart form those situations, where a controlled drug-release is wanted. The chemical variety of polymers for medical application is large. However, all typical requirements cannot be met by one single polymer. Compromises have to be found between properties and application. Polymer selection for application in nephrology has always to be made under the premise of final application.

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