Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery

2001 ◽  
Vol 59 (3) ◽  
pp. 438-449 ◽  
Author(s):  
Fwu-Long Mi ◽  
Yu-Bey Wu ◽  
Shin-Shing Shyu ◽  
Jen-Yu Schoung ◽  
Yaw-Bin Huang ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Wound Infections ◽  
Antibiotic Delivery

scholarly journals Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Antibiotics ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 56 ◽  
Author(s):  
R. Smith ◽  
J. Russo ◽  
J. Fiegel ◽  
N. Brogden
Keyword(s):  
Negative Impact ◽  
Skin Barrier ◽  
The Body ◽  
Skin Infections ◽  
Wound Infections ◽  
Innate Defense ◽  
Delivery Strategies ◽  
Antimicrobial Treatments ◽  
Antibiotic Delivery

The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections

2017 ◽  
Vol 5 (43) ◽  
pp. 8451-8458 ◽  
Author(s):  
Yingnan Zhu ◽  
Jiamin Zhang ◽  
Jiayin Song ◽  
Jing Yang ◽  
Tong Xu ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Wound Infections ◽  
Step Method ◽  
Healing Wound ◽  
One Step

A PCB–AgNP hydrogel was fabricated using a one-step method and demonstrated to efficiently treat wound infections.

scholarly journals MODERN WOUND DRESSING FOR WOUND INFECTION: AN OVERVIEW

2015 ◽  
Vol 3 (1) ◽  
pp. 39 ◽  
Author(s):  
Novida Rizani
Keyword(s):  
Wound Healing ◽  
Antimicrobial Agent ◽  
Wound Infection ◽  
Wound Dressing ◽  
Healing Rate ◽  
Wound Infections ◽  
Bioactive Agent

When the tissue of skin is break means a wound is happens. To seal it, many choices of wound healing are available. Moist wound dressing can be better optional than the conservative ones. A bioactive agent that being added at the dressing in fact can increase healing rate of wound, moreover can subjugate wound infection caused by the pathogens, and also capable to prevent it. In this review, there are summary of modern moist wound healing, the wound pathogens, and some of sturdy bioactive agent for wound dressing. The treatment of wound infections using impregnated wound dressing by bioactive agent can also by antimicrobial agent that will striven against bacteria colonial.

Wound care

2016 ◽  
Author(s):  
Patricia Davies
Keyword(s):  
Wound Dressing ◽  
Wound Care ◽  
Surgical Site Infections ◽  
Surgical Patients ◽  
Wound Infections ◽  
Site Infection ◽  
Secondary Intention ◽  
Wound Assessment ◽  
Healing Wound ◽  
Operative Assessment

It is imperative that the surgical nurse has a good understanding of wound care, as all surgical patients will have a wound of some description. Prevention of surgical site infection begins with a pre-operative assessment and continues post-operatively with the assessment of the wound dressing and the surgical site. This chapter discusses the physiology of wound healing, wound assessment, and dressings for primary- and secondary-intention wounds. This chapter also outlines the prevention of surgical site infections, and common wound infections and their treatment.

scholarly journals New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

2020 ◽  
Vol 21 (2) ◽  
pp. 393 ◽  
Author(s):  
Eliana B. Souto ◽  
André F. Ribeiro ◽  
Maria I. Ferreira ◽  
Maria C. Teixeira ◽  
Andrea A. M. Shimojo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressing ◽  
Systemic Exposure ◽  
Mortality Rates ◽  
Wound Infections ◽  
Risk Of Infection ◽  
Significant Morbidity ◽  
Burn Wound ◽  
Skin Integrity ◽  
Systemic Antibiotics

Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

A Novel Wound Dressing With an Antibiotic Delivery System Stimulated by Microbial Infection

ASAIO Journal ◽  
1997 ◽  
Vol 43 (5) ◽  
pp. M858 ◽  
Author(s):  
YOSHIHISA SUZUKI ◽  
MASAO TANIHARA ◽  
YOSHIHIKO NISHIMURA ◽  
KYOKO SUZUKI ◽  
YOSHIMI KAKIMARU ◽  
...  
Keyword(s):  
Delivery System ◽  
Wound Dressing ◽  
Microbial Infection ◽  
Antibiotic Delivery

scholarly journals Antibiotic-Loaded Psyllium Husk Hemicellulose and Gelatin-Based Polymeric Films for Wound Dressing Application

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 236
Author(s):  
Naveed Ahmad ◽  
Muhammad Masood Ahmad ◽  
Nabil K. Alruwaili ◽  
Ziyad Awadh Alrowaili ◽  
Fadhel Ahmed Alomar ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Drug Release ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Wound Dressings ◽  
Patient Comfort ◽  
Wound Infections ◽  
Psyllium Husk ◽  
Antibiotic Release

Wound infections are one of the major reasons for the delay in the healing of chronic wounds and can be overcome by developing effective wound dressings capable of absorbing exudate, providing local antibiotic release, and improving patient comfort. Arabinoxylan (AX) is a major hemicellulose present in psyllium seed husk (PSH) and exhibits promising characteristics for developing film dressings. Herein, AX-gelatin (GL) films were prepared by blending AX, gelatin (GL), glycerol, and gentamicin (antibiotic). Initially, the optimal quantities of AX, GL, and glycerol for preparing transparent, bubble-free, smooth, and foldable AX-GL films were found. Physiochemical, thermal, morphological, drug release, and antibacterial characteristics of the AX-GL films were evaluated to investigate their suitability as wound dressings. The findings suggested that the mechanical, water vapor transmission, morphological, and expansion characteristics of the optimized AX-GL films were within the required range for wound dressing. The results of Fourier-transform infrared (FTIR) analyses suggested chemical compatibility among the ingredients of the films. In in vitro drug release and antibacterial activity experiments, gentamicin (GM)-loaded AX-GL films released approximately 89% of the GM in 24 h and exhibited better antibacterial activity than standard GM solution. These results suggest that AX-GL films could serve as a promising dressing to protect against wound infections.

scholarly journals A novel wound dressing with antibiotic delivery system stimulated by microbial infection

ASAIO Journal ◽  
1997 ◽  
Vol 43 (2) ◽  
pp. 86 ◽  
Author(s):  
Y. Suzuki ◽  
Y. Nishimura ◽  
M. Tanihara ◽  
K. Suzuki ◽  
Y. Kakimaru ◽  
...  
Keyword(s):  
Delivery System ◽  
Wound Dressing ◽  
Microbial Infection ◽  
Antibiotic Delivery
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