scholarly journals New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

2020 ◽  
Vol 21 (2) ◽  
pp. 393 ◽  
Author(s):  
Eliana B. Souto ◽  
André F. Ribeiro ◽  
Maria I. Ferreira ◽  
Maria C. Teixeira ◽  
Andrea A. M. Shimojo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressing ◽  
Systemic Exposure ◽  
Mortality Rates ◽  
Wound Infections ◽  
Risk Of Infection ◽  
Significant Morbidity ◽  
Burn Wound ◽  
Skin Integrity ◽  
Systemic Antibiotics

Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

scholarly journals Antibiotic therapy and infection complications in paediatric burn injuries

2019 ◽  
Vol 73 ◽  
pp. 1-8
Author(s):  
Jakub Noskiewicz ◽  
Paweł Juszczak ◽  
Małgorzata Rzanny- Owczarzak ◽  
Przemysław Mańkowski
Keyword(s):  
Antibiotic Therapy ◽  
Thermal Injury ◽  
Treatment Time ◽  
Burn Injuries ◽  
Wound Infections ◽  
Risk Of Infection ◽  
Negative Effects ◽  
Burn Wound ◽  
Prophylactic Measure ◽  
Burn Disease

Background: Each year, nearly 1% of population suffers from burn injuries. The main cause of complications and death after thermal injury is infections. Excessive use of antibiotics affects however the children treated for burns and can have negative effects. Therefore, specifying the recommendations for antibiotic therapy in patients after thermal injury seems to be of importance. Materials and methods: An evaluation of 310 paediatric patients hospitalised for burn injuries was performed. In the first part of evaluation, a retrospective analysis of treatment with particular focus on infection complications and administered antibiotics was performed. This was followed by a prospective evaluation of effectiveness of the principles of antibiotic therapy specified at the earlier stage. Results: In 2010-2016, an antibiotic was systemically administered to 53.4% of children treated for thermal injury, provided that in 87.1% of cases it was introduced as a prophylactic measure. Infection of a burn wound was recorded in 4.7% of cases. The most frequently isolated bacterium (57.1%) was Staphylococcus aureus MSSA. Supply of antibiotics failed to reduce the number of infection complications or burn wound infections. The studies formed the basis for specification of the internal antibiotic therapy criteria, effectiveness of which was then evaluated. In 2017, an antibiotic was administered to 37.1% of patients. Reducing antibiotic therapy did not increase the risk of infection complications or frequency of wound infections. Conclusion: Routine antibiotic prophylaxis in burn injuries has no effect on the risk of infection complications and does not reduce the treatment time. It should be limited to perioperative prophylaxis in the case of skin grafts and to the patients with progressing symptoms of burn disease or with concomitant infections.

scholarly journals Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Philippe Abdel-Sayed ◽  
Ariane Kaeppeli ◽  
Thissa Siriwardena ◽  
Tamis Darbre ◽  
Karl Perron ◽  
...  
Keyword(s):  
Healing Process ◽  
Multidrug Resistant ◽  
Burn Patients ◽  
Drug Resistant ◽  
Wound Infections ◽  
Significant Morbidity ◽  
Burn Wound ◽  
Skin Cells ◽  
Angiogenic Effect ◽  
Healing Processes

Abstract Multi-drug resistant Pseudomonas aeruginosa has increased progressively and impedes further regression in mortality in burn patients. Such wound infections serve as bacterial reservoir for nosocomial infections and are associated with significant morbidity and costs. Anti-microbial polycationic dendrimers G3KL and G3RL, able to kill multi-drug resistant P. aeruginosa, have been previously developed. The combination of these dendrimers with a class of biological bandages made of progenitor skin cells, which secrete growth factors, could positively impact wound-healing processes. However, polycations are known to be used as anti-angiogenic agents for tumor suppression. Since, neovascularization is pivotal in the healing of deep burn-wounds, the use of anti-microbial dendrimers may thus hinder the healing processes. Surprisingly, we have seen in this study that G3KL and G3RL dendrimers can have angiogenic effects. Moreover, we have shown that a dendrimer concentration ranging between 50 and 100 μg/mL in combination with the biological bandages can suppress bacterial growth without altering cell viability up to 5 days. These results show that antimicrobial dendrimers can be used in combination with biological bandages and could potentially improve the healing process with an enhanced angiogenesis.

Antibacterial activity of chitosan-based nanohybrid membranes against drug-resistant bacterial isolates from burn wound infections

2021 ◽  
Author(s):  
Pouya Amiri ◽  
Jalil Kardan-Yamchi ◽  
Hossein Kazemian ◽  
Faranak Rezaei
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
Antibacterial Effect ◽  
Antibacterial Efficacy ◽  
Drug Resistant ◽  
Wound Infections ◽  
Bacterial Isolates ◽  
Burn Wound ◽  
Vancomycin Resistant ◽  
Application Prospects

Abstract Biocompatible and non-toxic properties of chitosan make it a candidate with excellent application prospects in developing wound dressing conjugate compounds. Six different chitosan-based nanohybrid membranes were evaluated against multi-drug resistant bacterial isolates. Twenty-seven drug-resistant Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, and Pseudomonas aeruginosa species were isolated from burn wound infections. Different combinations of chitosan, ciprofloxacin (CIP), biofunctionalized montmorillonite (MMT), and montmorillonite with sulfate chains (SMMT) were provided, and their antibacterial activity was assessed using the colony count method. Six Methicillin-resistant S. aureus, seven vancomycin-resistant E. faecalis, four A. baumannii, and 10 P. aeruginosa multi-drug resistant were identified. Chitosan and montmorillonite did not show significant antibacterial effect but, chitosan/SMMT/CIP was the most effective nanocomposite. Chitosan-based nanocomposites with ciprofloxacin could effectively reduce the susceptibility of drug-resistant bacterial isolates. Bacterial targeting using nanosystems provides an opportunity for effective antibiotic treatment by improving antibacterial efficacy.

The coat burn wound dressing

Burns ◽  
1984 ◽  
Vol 10 (3) ◽  
pp. 197-199 ◽  
Author(s):  
Moisey Levin ◽  
Theodor Kaufman ◽  
Dennis J. Hurwitz
Keyword(s):  
Wound Dressing ◽  
Burn Wound

Zastosowanie opatrunków srebrowych w leczeniu oparzeń i odmrożeń, zespołu Lyella oraz ran przewlekłych

2020 ◽  
Vol 8 (4) ◽  
pp. 115-122
Author(s):  
Ryszard Mądry ◽  
Jerzy Strużyna
Keyword(s):  
Chronic Wounds ◽  
Pain Patient ◽  
Immune Disorders ◽  
Burn Wound ◽  
Treatment Progress ◽  
Skin Integrity ◽  
Reduction Of Pain ◽  
Thermal Injuries ◽  
Lyell’S Syndrome ◽  
Lyell's Syndrome

The skin is the largest organ of the human body and is composed of several layers each having different properties and physiological functions. The loss of skin integrity due to injury or disease can lead to acute physiological and immune disorders which may even result in death. The following properties are taken into consideration when choosing an appropriate dressing for the burn wound: the ability to support epithelialization and granulation, reduction of pain, patient discomfort, and costs. The aim of this study is to evaluate the usefulness of silver dressings in treatment of burns, frostbites, Lyell’s syndrome and chronic wounds. The use of silver dressings in thermal injuries, Lyell’s syndrome and chronic wounds had a significant effect on treatment progress. Silver dressings can be a temporary substitute for the epidermis in burns, frostbites, Lyell’s syndrome and chronic wounds.

scholarly journals Febrile Neutropenia and Long-term Risk of Infection Among Patients Treated With Chemotherapy for Malignant Diseases

2018 ◽  
Vol 5 (10) ◽  
Author(s):  
Josefine Nordvig ◽  
Theis Aagaard ◽  
Gedske Daugaard ◽  
Peter Brown ◽  
Henrik Sengeløv ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Mortality Rates ◽  
Risk Of Infection ◽  
Increased Risk ◽  
Competing Events ◽  
Adjusted Incidence Rate ◽  
New Treatment ◽  
Rate Ratios

Abstract Background Febrile neutropenia (FN) is a common complication to chemotherapy, associated with increased short-term morbidity and mortality. However, the long-term outcomes after FN are poorly elucidated. We examined the long-term risk of infection and mortality rates in cancer patients with and without FN. Methods Patients aged >16 years treated with firstline chemotherapy were followed from 180 days after initiating chemotherapy until first infection, a new treatment with chemotherapy, death, or end of follow-up. Risk factors for infections were analyzed by competing risks regression, with death or another treatment with chemotherapy as competing events. Adjusted incidence rate ratios (aIRRs) of infection and death were analyzed using Poisson regression. In analyses of mortality, infection was included as a time-updated variable. Results We included 7190 patients with a median follow-up (interquartile range) of 0.58 (0.20–1.71) year. A total of 1370 patients had an infection during follow-up. The aIRRs of infection were 1.86 (95% confidence interval [CI], 1.56–2.22) and 2.19 (95% CI, 1.54–3.11) for patients with 1 or >1 episode of FN compared with those without FN. Mortality rate ratios were 7.52 (95% CI, 6.67–8.48) <1 month after, 4.24 (95% CI, 3.80–4.75) 1–3 months after, 2.33 (95% CI, 1.63–3.35) 3–6 months after, and 1.09 (95% CI, 0.93–1.29) >6 months after an infection, compared with the time before infection. Conclusions FN during chemotherapy is associated with a long-term increased risk of infection. Mortality rates are substantially increased for 6 months following an infection.

scholarly journals Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolated from Burn Wound Infections

2016 ◽  
Vol 5 (9) ◽  
pp. 400-404 ◽  
Author(s):  
Khulood Abdulkareen Hussein ◽  
Zainab Alag Hasan ◽  
Utoor Talib Jassim ◽  
Abdulameer Abdullah Al-Mussawi
Keyword(s):  
Klebsiella Pneumoniae ◽  
Wound Infections ◽  
Burn Wound ◽  
Extended Spectrum
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