3D in vivo imaging with extended-focus optical coherence microscopy

2017 ◽  
Vol 10 (11) ◽  
pp. 1411-1420 ◽  
Author(s):  
Yu Chen ◽  
Le A. Trinh ◽  
Jeff Fingler ◽  
Scott E. Fraser
Keyword(s):  
In Vivo Imaging ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

scholarly journals In vivo imaging of corneal nerves and cellular structures in mice with Gabor-domain optical coherence microscopy

2020 ◽  
Vol 11 (2) ◽  
pp. 711 ◽  
Author(s):  
Cristina Canavesi ◽  
Andrea Cogliati ◽  
Amanda Mietus ◽  
Yue Qi ◽  
Jesse Schallek ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Cellular Structures ◽  
Optical Coherence ◽  
Optical Coherence Microscopy ◽  
Corneal Nerves ◽  
Gabor Domain

3D wide field-of-view Gabor-domain optical coherence microscopy advancing real-time in-vivo imaging and metrology

2017 ◽  
Author(s):  
Cristina Canavesi ◽  
Andrea Cogliati ◽  
Adam Hayes ◽  
Patrice Tankam ◽  
Anand Santhanam ◽  
...  
Keyword(s):  
Real Time ◽  
In Vivo Imaging ◽  
Field Of View ◽  
Wide Field ◽  
Optical Coherence ◽  
Optical Coherence Microscopy ◽  
Wide Field Of View ◽  
Gabor Domain

scholarly journals In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Diabetologia ◽  
2009 ◽  
Vol 52 (8) ◽  
pp. 1599-1607 ◽  
Author(s):  
M. Villiger ◽  
J. Goulley ◽  
M. Friedrich ◽  
A. Grapin-Botton ◽  
P. Meda ◽  
...  
Keyword(s):  
Islets Of Langerhans ◽  
In Vivo Imaging ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

scholarly journals 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jun Zhu ◽  
Hercules Rezende Freitas ◽  
Izumi Maezawa ◽  
Lee-way Jin ◽  
Vivek J. Srinivasan
Keyword(s):  
Minimally Invasive ◽  
Mouse Brain ◽  
Numerical Aperture ◽  
Optical Biopsy ◽  
Optical Coherence ◽  
Label Free ◽  
Optical Coherence Microscopy ◽  
Minimal Invasiveness ◽  
Cortical Regions

AbstractIn vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700 nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and optimized. Imaging through a thinned-skull preparation that preserves intracranial space, we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex, and some sub-cortical regions. In an Alzheimer’s disease model, we report that findings in superficial and deep cortical layers diverge, highlighting the importance of deep optical biopsy. Compared to other microscopic techniques, our 1700 nm OCM approach achieves a unique combination of intrinsic contrast, minimal invasiveness, and high resolution for deep brain imaging.

scholarly journals In Vivo Imaging and Morphometry of the Human Pre-Descemet's Layer and Endothelium With Ultrahigh-Resolution Optical Coherence Tomography

2016 ◽  
Vol 57 (6) ◽  
pp. 2782 ◽  
Author(s):  
Kostadinka Bizheva ◽  
Lacey Haines ◽  
Erik Mason ◽  
Benjamin MacLellan ◽  
Bingyao Tan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
In Vivo Imaging ◽  
Optical Coherence ◽  
Ultrahigh Resolution

Swept source optical coherence tomography for in vivo imaging and vibrometry in the apex of the mouse cochlea

2015 ◽  
Author(s):  
Hee Yoon Lee ◽  
Patrick D. Raphael ◽  
Audrey K. Ellerbee ◽  
Brian E. Applegate ◽  
John S. Oghalai
Keyword(s):  
Optical Coherence Tomography ◽  
In Vivo Imaging ◽  
Optical Coherence ◽  
Swept Source
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