High-definition optical coherence tomography of melanocytic skin lesions

2014 ◽  
Vol 8 (8) ◽  
pp. 681-686 ◽  
Author(s):  
Thilo Gambichler ◽  
Iris Plura ◽  
Monika Schmid-Wendtner ◽  
Konstantinos Valavanis ◽  
Daniela Kulichova ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Lesions ◽  
Optical Coherence ◽  
High Definition

scholarly journals Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy

2020 ◽  
pp. 1-9
Author(s):  
Sabrina Bergeron ◽  
Bryan Arthurs ◽  
Debra-Meghan Sanft ◽  
Christina Mastromonaco ◽  
Miguel N. Burnier Jr.
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Coherence Tomography ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Skin Lesions ◽  
Sebaceous Carcinoma ◽  
Optical Coherence ◽  
Oct Imaging

<b><i>Introduction:</i></b> Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. <b><i>Objective:</i></b> We aim to validate OCT as an imaging modality for peri-ocular skin cancer. Through a series of cases, we highlight findings for 3 common eyelid malignancies: basal cell carcinoma, squamous cell carcinoma and sebaceous carcinoma. We propose an OCT image-based signature for basal cell carcinoma. <b><i>Methods:</i></b> This is a prospective study. Fifty-eight lesions suspicious of malignancy from 57 patients were subjected to OCT imaging prior to the surgical excision of the lesion. OCT images were analysed and scored according to previously identified OCT features. Eight representative examples are presented, highlighting the OCT patterns for each malignancy side by side to its corresponding histopathological sections. <b><i>Results:</i></b> Out of the 58 lesions analysed, 53 were malignant. A loss of the dermal-epidermal junction is observed in all malignant lesions. A strong link is observed between the presence of subepithelial hyporeflective nests on OCT and the diagnosis of basal cell carcinoma (present in 83% of cases). Conversely, lesions of epithelial origin such as squamous cell carcinoma are most often represented on OCT by acanthosis. Two supplementary cases, one basal cell carcinoma and one sebaceous carcinoma, are provided to illustrate how OCT imaging is a valuable tool in cases where clinical observations may be unusual. <b><i>Conclusions:</i></b> We provide evidence supporting the use of OCT for the evaluation of peri-ocular cancers. OCT enables visualization of the skin layers in vivo, before biopsy. Our results show that certain OCT features can contribute to include or exclude a diagnosis of basal cell carcinoma. By integrating this non-invasive imaging methodology into the routine assessment of peri-ocular skin lesions, especially in health care centres where access to specialists is limited, OCT imaging can increase clinical precision, reduce delays in patient referral and enhance patient care.

In vivodetermination of epidermal thickness using high-definition optical coherence tomography

2014 ◽  
Vol 170 (3) ◽  
pp. 737-739 ◽  
Author(s):  
T. Gambichler ◽  
K. Valavanis ◽  
I. Plura ◽  
D. Georgas ◽  
P. Kampilafkos ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Epidermal Thickness ◽  
High Definition

scholarly journals High-definition optical coherence tomography imaging for noninvasive examination of heritage works

2016 ◽  
Vol 55 (36) ◽  
pp. 10313 ◽  
Author(s):  
Farzana Zaki ◽  
Isabella Hou ◽  
Denver Cooper ◽  
Divya Patel ◽  
Yi Yang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
High Definition ◽  
Tomography Imaging ◽  
Optical Coherence Tomography Imaging

Evaluation of Corneal Epithelial Thickness Imaged by High Definition Optical Coherence Tomography in Healthy Eyes

Cornea ◽  
2019 ◽  
Vol 38 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Elmira Baghdasaryan ◽  
Tudor C. Tepelus ◽  
Kenneth M. Marion ◽  
Homayoun Bagherinia ◽  
SriniVas R. Sadda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
High Definition ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness ◽  
Healthy Eyes

High-Definition Optical Coherence Tomography

2020 ◽  
pp. 241-249
Author(s):  
Mariano Suppa ◽  
Makiko Miyamoto ◽  
Véronique Del Marmol ◽  
Marc Boone
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
High Definition

scholarly journals Swept Source Optical Coherence Tomography Assessment of Bursa Premacularis in Healthy Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Paolo Carpineto ◽  
Rossella D’Aloisio ◽  
Daniele Guarini ◽  
Carla Iafigliola ◽  
Luca Cerino ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraclass Correlation ◽  
Optical Coherence ◽  
High Definition ◽  
Swept Source ◽  
Visualization Software ◽  
En Face ◽  
Bursa Premacularis ◽  
Youth Population ◽  
En Face Imaging

Purpose. To describe the reliability and the limits of bursa premacularis (BPM) evaluation using a swept source optical coherence tomography (SS-OCT) device with enface and 16 mm-high definition (HD) longitudinal scans. Methods. 60 eyes of 60 subjects were enrolled and imaged with SS-OCT system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). BPM area was measured using enface scans imported to ImageJ. HD horizontal and vertical longitudinal scans centered at the fovea were used to detect width (W) and central thickness (CT) of BPM at baseline (T0) and after 30 minutes (T30) performed by two different observers. An enhanced vitreous visualization software provided by the manufacturer of the device was used to highlight vitreous structures. Results. BPM was identifiable in 100% of eyes using both horizontal and vertical longitudinal scans. On horizontal scan, BPM was not entirely measurable in 21.7% and in 18.3% of cases at T0 and T30, respectively. On vertical scan, BPM was not entirely measurable in 75.0% and in 81.7% at T0 and T30, respectively. No statistically significant differences were found between the two different time measurements with an intraclass correlation coefficient above 70%. Median BPM area was 26.9 (Q1-Q3: 19.5-40.5) mm2. In en face imaging, the most frequent BPM shape was the boat one. Conclusion. SS-OCT is a reliable tool for a detailed quantification and mapping of BPM, and it is able to add useful details about the morphological BPM features in youth population. However, the enhanced visualization of the vitreous structures is still a challenge, also with the most forefront devices.

scholarly journals High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

Ophthalmology ◽  
2006 ◽  
Vol 113 (11) ◽  
pp. 2054-2065.e3 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Maciej Wojtkowski ◽  
Andre J. Witkin ◽  
Jay S. Duker ◽  
Tony H. Ko ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Optical Coherence ◽  
High Definition ◽  
Ultrahigh Resolution ◽  
3 Dimensional
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