Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats

2004 ◽  
Vol 24 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Süleyman Özen ◽  
Ömer Akyol ◽  
Mustafa Iraz ◽  
Sadık Söğüt ◽  
Fikret Özuğurlu ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Active Component ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Sumeyya Akyol ◽  
Veli Ugurcu ◽  
Aynur Altuntas ◽  
Rukiye Hasgul ◽  
Ozlem Cakmak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Renal Injury ◽  
Active Component ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Oxidative Injury ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Agent

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

Role of Vagal Activity on Bradicardic and Hypotensive Effects of Caffeic Acid Phenethyl Ester (CAPE)

2005 ◽  
Vol 5 (4) ◽  
pp. 391-396 ◽  
Author(s):  
Mustafa Iraz ◽  
Ersin Fadillioglu ◽  
Seda Tasdemir ◽  
Selim Erdogan
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Vagal Activity

Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1

2008 ◽  
Vol 591 (1-3) ◽  
pp. 28-35 ◽  
Author(s):  
Xinyu Wang ◽  
Salomon Stavchansky ◽  
Baiteng Zhao ◽  
James A. Bynum ◽  
Sean M. Kerwin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

Toxic Effects of Isoniazid and Rifampicin on Rat Brain Tissue: The Preventive Role of Caffeic Acid Phenethyl Ester

2012 ◽  
Vol 8 (6) ◽  
pp. 555-560 ◽  
Author(s):  
Mehmet Ugur Cevik ◽  
Abdullah Acar ◽  
Halis Tanriverdi ◽  
Sefer Varol ◽  
Adalet Arikanoglu ◽  
...  
Keyword(s):  
Rat Brain ◽  
Caffeic Acid ◽  
Brain Tissue ◽  
Caffeic Acid Phenethyl Ester ◽  
Toxic Effects ◽  
Preventive Role ◽  
Rat Brain Tissue

Protective role of caffeic acid phenethyl ester and erdosteine on activities of purine-catabolizing enzymes and level of nitric oxide in red blood cells of isoniazid-administered rats*

2008 ◽  
Vol 24 (8) ◽  
pp. 519-524 ◽  
Author(s):  
HR Yilmaz ◽  
E Uz ◽  
O Gökalp ◽  
N Özçelik ◽  
E Çiçek ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Red Blood Cells ◽  
Caffeic Acid ◽  
Blood Cells ◽  
Tap Water ◽  
Treated Group ◽  
Caffeic Acid Phenethyl Ester ◽  
Male Rats ◽  
Control Group

The aim of this experimental study was to investigate the possible role of nitric oxide (NO) and the activities of adenosine deaminase (ADA) and xanthine oxidase (XO) in the pathogenesis of isoniazid (INH)-induced oxidative damage in red blood cells (RBCs), and also to show the effect of caffeic acid phenethyl ester (CAPE) and erdosteine, antioxidants, in decreasing this toxicity. A total of 25 adult male rats were divided into four experimental groups as follows: control group ( n = 7), INH-treated group ( n = 6), INH + CAPE–treated group ( n = 6), and INH + erdosteine–treated group ( n = 6). INH, INH-CAPE, and INH-erdosteine–treated groups were treated orally with INH 50 mg/kg daily and with the tap water for 15 days. Control group was given only tap water. CAPE was intraperitoneally injected for 15 days at a dose of 10 μmol/kg. Erdosteine was treated orally for 15 days at a dose of 10 mg/kg/day. The injection of INH led to a significant increase in the activities of ADA, XO, and NO levels in RBCs of rats. Co-treatment with CAPE caused a significant decrease in the activities of ADA and XO and the levels of NO in RBCs. In addition, co-treatment with erdosteine caused a significant decrease in the activities of ADA and XO and the levels of NO in RBCs. The results of this study showed that ADA, XO, and NO may play an important role in the pathogenesis of INH-induced oxidative stress in RBCs. CAPE and erdosteine may have protective potential in this process and they may become a promising drug in the prevention of this undesired side effect of INH.

Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester

2006 ◽  
Vol 22 (6) ◽  
pp. 241-247 ◽  
Author(s):  
Faruk Öktem ◽  
H Ramazan Yilmaz ◽  
Fehmi Ozguner ◽  
Seref Olgar ◽  
Ali Ayata ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats

Toxicology ◽  
2005 ◽  
Vol 207 (2) ◽  
pp. 169-177 ◽  
Author(s):  
H. Parlakpinar ◽  
S. Tasdemir ◽  
A. Polat ◽  
A. Bay-Karabulut ◽  
N. Vardi ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Renal Toxicity ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Role
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