scholarly journals Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Sumeyya Akyol ◽  
Veli Ugurcu ◽  
Aynur Altuntas ◽  
Rukiye Hasgul ◽  
Ozlem Cakmak ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Renal Injury ◽  
Active Component ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Oxidative Injury ◽  
Caffeic Acid Phenethyl Ester ◽  
Protective Agent

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin

2020 ◽  
Vol 98 (5) ◽  
pp. 296-303 ◽  
Author(s):  
Biljana Stošić ◽  
Radmilo Janković ◽  
Marija Stošić ◽  
Danica Marković ◽  
Ines Veselinović ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Tissue Damage ◽  
Tissue Injury ◽  
Microscopic Analysis ◽  
Caffeic Acid Phenethyl Ester ◽  
Pancreatic Tissue ◽  
Protective Agent ◽  
Necrosis Factor Alpha ◽  
Male Wistar Rats ◽  
Main Activity

Application of cisplatin (CP) for the treatment of different cancers is known to cause pancreatitis through an increase in reactive oxygen species production and promotion of inflammation. Caffeic acid phenethyl ester (CAPE), the main activity carrier of propolis extracts, was previously found to possess numerous beneficial properties. This study aims to determine for the first time the potential of CAPE in preventing CP-induced pancreatic tissue damage by studying the changes occurring on both biochemical and microscopic levels. The levels of serum α-amylase and a panel of pancreatic tissue biomarkers related to tissue injury (reduced glutathione, xanthine oxidase, malondialdehyde, and protein carbonylated concentration) and inflammation (myeloperoxidase, nitric oxide, and umor necrosis factor alpha) were studied in male Wistar rats treated with either CP alone or with CP and CAPE. Additionally, microscopic analysis of pancreatic tissue would be conducted as well. Application of CAPE together with CP statistically significantly prevented the disturbance in all here-studied pancreatic tissue damage and inflammation-related biomarkers. The changes in pancreas biochemical status was followed by morphological disturbance. The results of the present study suggest that CAPE could act as a protective agent in pancreatic damage that arises after CP application.

scholarly journals Research on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin

2020 ◽  
Vol 50 (8) ◽  
pp. 2032-2039
Author(s):  
Tayfun CEYLAN ◽  
Emin KAYMAK ◽  
Fazile CANTÜRK ◽  
Birkan YAKAN
Keyword(s):  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Testicular Damage

Protective effect of nitric oxide on ischemia/reperfusion-induced renal injury and endothelin-1 overproduction

2005 ◽  
Vol 517 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Hayato Kurata ◽  
Masanori Takaoka ◽  
Yasuhiro Kubo ◽  
Tomoaki Katayama ◽  
Hidenobu Tsutsui ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protective Effect ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Endothelin 1

scholarly journals Synthesis of caffeic acid sulfonamide derivatives and their protective effect against H2O2 induced oxidative damage in A549 cells

RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 9924-9933 ◽  
Author(s):  
Xiaoyu Peng ◽  
Tingjun Hu ◽  
Yuxue Zhang ◽  
Anran Zhao ◽  
Bharathi Natarajan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Caffeic Acid ◽  
A549 Cells ◽  
Oxidative Injury ◽  
Caffeic Acid Derivatives ◽  
Nrf2 Pathway

Synthesized caffeic acid derivatives exhibit protective effect on H2O2 induced oxidative injury in A549 cells via Nrf2 pathway.

The Activities of Antioxidant Enzymes and the Level of Malondialdehyde in Cerebellum of Rats Subjected to Methotrexate: Protective Effect of Caffeic Acid Phenethyl Ester

2006 ◽  
Vol 291 (1-2) ◽  
pp. 63-68 ◽  
Author(s):  
Ertugrul Uzar ◽  
Hasan Rifat Koyuncuoglu ◽  
Efkan Uz ◽  
H. Ramazan Yilmaz ◽  
Suleyman Kutluhan ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester
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