Fraxetin suppresses reactive oxygen species‐dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane‐induced neurotoxicity in hippocampal neuronal cells

2021 ◽  
Author(s):  
Tongyin Zhang ◽  
Botao Zhou ◽  
Junyi Sun ◽  
Jiangling Song ◽  
Limin Nie ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuronal Cells ◽  
Reactive Oxygen ◽  
Akt Pathway ◽  
Oxygen Species

scholarly journals Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reducedα-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Nikolaus Berndt ◽  
Sascha Bulik ◽  
Hermann-Georg Holzhütter
Keyword(s):  
Reactive Oxygen Species ◽  
Neurodegenerative Diseases ◽  
Neuronal Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Energy Metabolism ◽  
Atp Production ◽  
Dependent Inactivation ◽  
The Impact ◽  
Ketoglutarate Dehydrogenase

Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mitochondrial ATP generation, redox state, transmembrane potential, and generation of reactive oxygen species (ROS) by the respiratory chain (RC), we developed a detailed kinetic model. Model simulations revealed a threshold-like decline of the ATP production rate at about 60% inhibition of KGDHC accompanied by a significant increase of the mitochondrial membrane potential. By contrast, progressive inhibition of the enzyme aconitase had only little impact on these mitochondrial parameters. As KGDHC is susceptible to ROS-dependent inactivation, we also investigated the reduction state of those sites of the RC proposed to be involved in ROS production. The reduction state of all sites except one decreased with increasing degree of KGDHC inhibition suggesting an ROS-reducing effect of KGDHC inhibition. Our model underpins the important role of reduced KGDHC activity in the energetic breakdown of neuronal cells during development of neurodegenerative diseases.

Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells

1996 ◽  
Vol 733 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Takumi Satoh ◽  
Naoto Sakai ◽  
Yasushi Enokido ◽  
Yasuo Uchiyama ◽  
Hiroshi Hatanaka
Keyword(s):  
Reactive Oxygen Species ◽  
Neuronal Cells ◽  
Reactive Oxygen ◽  
Serum Deprivation ◽  
Oxygen Species ◽  
Survival Factor

Protection of neuronal cells against reactive oxygen species by carnosine and related compounds

2004 ◽  
Vol 137 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Alexander Boldyrev ◽  
Elena Bulygina ◽  
Toomas Leinsoo ◽  
Irina Petrushanko ◽  
Shiori Tsubone ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neuronal Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Related Compounds
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