Toxicokinetics of methylmercury in diabetic KK‐Ay mice and C57BL/6 mice

2020 ◽  
Author(s):  
Megumi Yamamoto ◽  
Rie Yanagisawa ◽  
Atsushi Sakai ◽  
Masaki Mogi ◽  
Satoshi Shuto ◽  
...  
Keyword(s):  
Ay Mice

Influence of the Digested Products of Royal Jelly on Insulin Levels in KK-Ay Mice

2012 ◽  
Vol 18 (2) ◽  
pp. 309-313
Author(s):  
Kyoko KOBAYASHI ◽  
Nobuyuki HITOMI ◽  
Kiyoshi MURATA ◽  
Hiroshi YOSHIZAKI ◽  
Kikuji YAMAGUCHI ◽  
...  
Keyword(s):  
Royal Jelly ◽  
Insulin Levels ◽  
Ay Mice

scholarly journals Erucic Acid-Rich Yellow Mustard Oil Improves Insulin Resistance in KK-Ay Mice

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 546
Author(s):  
Asako Takahashi ◽  
Mayu Ishizaki ◽  
Yoshifumi Kimira ◽  
Yukari Egashira ◽  
Shizuka Hirai
Keyword(s):  
Insulin Resistance ◽  
Erucic Acid ◽  
Metabolic Disorders ◽  
Transcriptional Activity ◽  
Mustard Oil ◽  
Luciferase Reporter ◽  
Peroxisome Proliferator ◽  
Mineral Density ◽  
Yellow Mustard ◽  
Ay Mice

Obesity is a major risk factor for some metabolic disorders including type 2 diabetes. Enhancement of peroxisome proliferator-activated receptor (PPAR) γ, a master regulator of adipocyte differentiation, is known to increase insulin-sensitive small adipocytes. In contrast, decreased PPARγ activity is also reported to improve insulin resistance. We have previously identified erucic acid as a novel natural component suppressing PPARγ transcriptional activity. In this study, we investigated the effect of erucic acid-rich yellow mustard oil (YMO) on obese/diabetic KK-Ay mice. An in vitro luciferase reporter assay and mesenchymal stem cell (MSC) differentiation assay revealed that 25 µg/mL YMO significantly inhibited PPARγ transcriptional activity and differentiation of MSCs into adipocytes but promoted their differentiation into osteoblasts. In KK-Ay mice, dietary intake of 7.0% (w/w) YMO significantly decreased the surrogate indexes for insulin resistance and the infiltration of macrophages into adipose tissue. Furthermore, 7.0% YMO increased bone mineral density. These results suggest that YMO can ameliorate obesity-induced metabolic disorders.

Potent anti-obesity effect of acetate; acetate may alter the expression of genes involved in beige adipogenesis in obese KK-Ay mice

2016 ◽  
Vol 120 ◽  
pp. S83 ◽  
Author(s):  
Hiroyuki Motoshima ◽  
Satoko Hanatani ◽  
Yuki Takaki ◽  
Shuji Kawasaki ◽  
Motoyuki Igata ◽  
...  
Keyword(s):  
Expression Of Genes ◽  
Ay Mice

scholarly journals Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

2012 ◽  
Vol 58 (6) ◽  
pp. 408-414 ◽  
Author(s):  
Misato KOBAYASHI ◽  
Yuji MATSUDA ◽  
Hiroshi IWAI ◽  
Masanori HIRAMITSU ◽  
Takashi INOUE ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Akt Phosphorylation ◽  
Ay Mice

scholarly journals Hepatic fatty acid biosynthesis in KK-Ay mice is modulated by administration of persimmon peel extract: A DNA microarray study

2018 ◽  
Vol 6 (6) ◽  
pp. 1657-1663
Author(s):  
Ryoichi Izuchi ◽  
Tomoko Ishijima ◽  
Shinji Okada ◽  
Keiko Abe ◽  
Yuji Nakai
Keyword(s):  
Fatty Acid ◽  
Dna Microarray ◽  
Fatty Acid Biosynthesis ◽  
Acid Biosynthesis ◽  
Microarray Study ◽  
Hepatic Fatty Acid ◽  
Peel Extract ◽  
Ay Mice

Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice

2010 ◽  
Vol 504 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Masashi Hosokawa ◽  
Tatsuya Miyashita ◽  
Sho Nishikawa ◽  
Shingo Emi ◽  
Takayuki Tsukui ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mrna Expression ◽  
White Adipose Tissue ◽  
Ay Mice

Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice

2015 ◽  
Vol 171 ◽  
pp. 161-170 ◽  
Author(s):  
Xinzhou Yang ◽  
Jing Yang ◽  
Chan Xu ◽  
Mi Huang ◽  
Qi Zhou ◽  
...  
Keyword(s):  
Sophora Flavescens ◽  
Etoac Extract ◽  
Type 2 Diabetic ◽  
Ay Mice ◽  
Antidiabetic Effects

scholarly journals Diabetic Nephropathy in KK and KK-Ay Mice.

2002 ◽  
Vol 51 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Masako OKAZAKI ◽  
Yukako SAITO ◽  
Yuko UDAKA ◽  
Mine MARUYAMA ◽  
Hidetomo MURAKAMI ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Ay Mice
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