scholarly journals Hepatic fatty acid biosynthesis in KK-Ay mice is modulated by administration of persimmon peel extract: A DNA microarray study

2018 ◽  
Vol 6 (6) ◽  
pp. 1657-1663
Author(s):  
Ryoichi Izuchi ◽  
Tomoko Ishijima ◽  
Shinji Okada ◽  
Keiko Abe ◽  
Yuji Nakai
Keyword(s):  
Fatty Acid ◽  
Dna Microarray ◽  
Fatty Acid Biosynthesis ◽  
Acid Biosynthesis ◽  
Microarray Study ◽  
Hepatic Fatty Acid ◽  
Peel Extract ◽  
Ay Mice

Regulation of fatty acid biosynthesis in rats by physical training

1984 ◽  
Vol 56 (4) ◽  
pp. 1060-1064 ◽  
Author(s):  
R. Scorpio ◽  
R. L. Rigsby ◽  
D. R. Thomas ◽  
B. D. Gardner
Keyword(s):  
Fatty Acid ◽  
Physical Training ◽  
Fatty Acid Biosynthesis ◽  
Male Rats ◽  
Maximal Velocity ◽  
Acetyl Coa Carboxylase ◽  
Acid Biosynthesis ◽  
Acetyl Coa ◽  
Carboxylase Activity ◽  
Hepatic Fatty Acid

Physical training in the form of long-term nonexhaustive daily exercise was studied as a means of regulating fatty acid biosynthesis. Male rats were required to swim for periods up to 90 min/day. The exercise was carried out 6 days/wk for approximately 11 wk. Hepatic fatty acid biosynthesis and acetyl-CoA carboxylase [acetyl-CoA: CO2 ligase (EC 6.4.1.2)] activities were compared with nonexercised rats. At the end of the training period the exercised rats had a lower rate of fatty acid biosynthesis activity and a lower rate of acetyl-CoA carboxylase activity. The difference in acetyl-CoA carboxylase activity was due to a change in maximal velocity with no significant change in the Michaelis constant for acetyl-CoA. Untrained rats were subjected to a single bout of exercise. They also exhibited lower rates of fatty acid biosynthesis and acetyl-CoA carboxylase activities compared with nonexercised rats. However, the lower rates of these enzyme activities were sustained longer in the physically trained rats compared with the exercised untrained rats after the cessation of exercise. These results implicate acetyl-CoA carboxylase as a control site in the regulation of hepatic fatty acid biosynthesis by both physical training and acute exercise in rats. Possible inhibitory mechanisms are discussed.

Inhibition of early steps of de novo fatty-acid biosynthesis by different xenobiotica

1991 ◽  
Vol 81 (2) ◽  
pp. 251-255
Author(s):  
Manfred Focke ◽  
Andrea Feld ◽  
Hartmut K. Lichtenthaler
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
De Novo ◽  
Acid Biosynthesis

Development of 'S', 'N’ Heterocycles as Antimycobacterials Targeting Fatty Acid Biosynthesis

2019 ◽  
Vol 15 ◽  
Author(s):  
L. K. Dahiwade ◽  
S. R. Rochlani ◽  
P. B. Choudhari ◽  
R. P. Dhavale ◽  
H. N. Moreira
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
Antimycobacterial Activity ◽  
Drug Candidate ◽  
Causative Organism ◽  
Present Communication ◽  
Acid Biosynthesis ◽  
Rational Development ◽  
After Cancer ◽  
Drug Resistant Strains

Background: Mycobacterium tuberculosis is a causative organism of tuberculosis, which is most deadly disease after cancer in a current decade. The development of multidrug and broadly drug- resistant strains making the tuberculosis problem more and more critical. In last 40 years, only one molecule is added to the treatment regimen. Generally, drug design and development programs are targeted proteins whose function is known to be essential to the bacterial cell. Objectives: Reported here are the development of 'S', 'N’ heterocycles as antimycobacterials targeting fatty acid biosynthesis. Material and Methods: In the present communication, rational development of anti-mycobacterial agent's targeting fatty acid biosynthesis has been done by integrating the pocket modelling and virtual analysis. Results: The identified potential 33 lead compounds were synthesized, characterized by physicochemical and spectroscopic methods like IR, NMR spectroscopy and further screened for antimycobacterial activity using isoniazid as standard. All the designed compounds have shown profound antimycobacterial activity. Conclusion: In this present communication, we found that 3c, 3f, 3l and 4k molecules had expressive desirable biological activity and specific interactions with fatty acids. Further optimization of these leads is necessary for the development of potential antimycobacterial drug candidate having less side effects.

scholarly journals Genome-Wide Mapping of Histone H3 Lysine 4 Trimethylation (H3K4me3) and Its Involvement in Fatty Acid Biosynthesis in Sunflower Developing Seeds

Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 706
Author(s):  
Antonio J. Moreno-Pérez ◽  
Raquel Martins-Noguerol ◽  
Cristina DeAndrés-Gil ◽  
Mónica Venegas-Calerón ◽  
Rosario Sánchez ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Chromatin Remodeling ◽  
Molecular Mechanisms ◽  
Acid Metabolism ◽  
Fatty Acid Biosynthesis ◽  
Acid Synthesis ◽  
Sunflower Seeds ◽  
Acid Biosynthesis ◽  
Functional Regions ◽  
Genome Wide

Histone modifications are of paramount importance during plant development. Investigating chromatin remodeling in developing oilseeds sheds light on the molecular mechanisms controlling fatty acid metabolism and facilitates the identification of new functional regions in oil crop genomes. The present study characterizes the epigenetic modifications H3K4me3 in relationship with the expression of fatty acid-related genes and transcription factors in developing sunflower seeds. Two master transcriptional regulators identified in this analysis, VIV1 (homologous to Arabidopsis ABI3) and FUS3, cooperate in the regulation of WRINKLED 1, a transcriptional factor regulating glycolysis, and fatty acid synthesis in developing oilseeds.

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