Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure

2013 ◽  
Vol 33 (10) ◽  
pp. 1165-1179 ◽  
Author(s):  
Shailendra Pratap Singh ◽  
Monika Kumari ◽  
Srinivas I. Kumari ◽  
Mohammed F. Rahman ◽  
M. Mahboob ◽  
...  
Keyword(s):  
Manganese Oxide ◽  
Wistar Rats ◽  
Toxicity Assessment ◽  
Oral Exposure

scholarly journals Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Douglas Rossi Jesus ◽  
Lorena Neris Barbosa ◽  
Thiago Bruno Lima Prando ◽  
Leonardo Franco Martins ◽  
Francielli Gasparotto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Assessment ◽  
Cassava Starch ◽  
Pharmaceutical Products ◽  
The Body ◽  
Oral Exposure ◽  
Oral Toxicity ◽  
Starch Acetate ◽  
Target Organs ◽  
And Control

The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm.

Subchronic toxicity of cerium nitrate by 90-day oral exposure in wistar rats

2019 ◽  
Vol 108 ◽  
pp. 104474 ◽  
Author(s):  
Yu Wu ◽  
Xiaoqiao Tang ◽  
Wenxiang Yang ◽  
Jun Fan ◽  
Lijun Tang ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Cerium Nitrate ◽  
Oral Exposure ◽  
Subchronic Toxicity

Genotoxicity, biochemical, and biodistribution studies of magnesium oxide nano and microparticles in albino wistar rats after 28-day repeated oral exposure

2017 ◽  
Vol 33 (4) ◽  
pp. 396-410 ◽  
Author(s):  
Bhanuramya Mangalampalli ◽  
Naresh Dumala ◽  
Rekhadevi Perumalla Venkata ◽  
Paramjit Grover
Keyword(s):  
Magnesium Oxide ◽  
Wistar Rats ◽  
Oral Exposure ◽  
Biodistribution Studies

scholarly journals Histomorphological Effects of Nicotine on Selected Parts of the Brain of Adult Wistar Rats

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
John Chukwuma Oyem ◽  
Emmanuel Igho Odokuma
Keyword(s):  
Substantia Nigra ◽  
Cell Count ◽  
Wistar Rats ◽  
Neuronal Cell ◽  
Oral Exposure ◽  
Control Group ◽  
Cell Diameter ◽  
Dependent Manner ◽  
Histological Techniques ◽  
Group 1

Nicotine has been defined as a potent parasympathomimetic alkaloid that accumulates in the roots and leaves of Nightshade family of plants Aim: This study was aimed at evaluating the effects of orally ingested nicotine in the histology of hippocampus, substantia nigra and cerebellum.Materials and Methods: Twenty four adult male Wistar rats (100g – 200g) were randomly divided into 4 groups (group 1 – group 4). Group 1 served as the control group, while groups 2 - 4 were the treated groups. Nicotine was diluted in water and 1ml of the different dosage (2mg/kg/day, 4mg/kg/day and 6mg/kg/day) were administered to the treated groups respectively with the aid of orogastric cannula for 42 days. Animals were euthanized by cervical dislocation at the end of 7, 21 and 42 days so as to demonstrate the dose and time dependant effect of this agent. Brain tissues were harvested, processed and stained using Haematoxylin and eosin according to standard histological techniques. Stained tissue images were captured using digital micrometer eyepiece and cell count was determined using stereological technique.Statistical analysis: Data obtained were subjected to statistical analysis with the use of statistical package for social sciences (SPSS version 20). Significant differences were obtained using One Way Analysis of Variance with a probability of  0.05 (95% confidence limit) and Tukeys post hoc  test was further used to determine the mean significant differences between specific groups.Results: Histological findings showed mild, moderate and severe hyperplasia in a dose and time dependant manner. However, observations from quantitative analysisalso revealed a dose and time dependant significant increase in neuronal cell count and cell diameter of the hippocampus, Substantia nigra and cerebellum.Conclusion: This study has demonstrated that oral exposure of Nicotine in rats display proliferative adaptive changes on the hippocampus, substantia nigra and cerebellum in a dose/time dependent manner.

scholarly journals Lipid Profile and Oxidative Stress Markers in Wistar Rats following Oral and Repeated Exposure to Fijk Herbal Mixture

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Oluyomi Stephen Adeyemi ◽  
Bukola Temitope Orekoya
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Herbal Remedy ◽  
Repeated Administration ◽  
Rat Plasma ◽  
Repeated Exposure ◽  
Atherogenic Index ◽  
Oral Exposure ◽  
Ether Anesthesia ◽  
Herbal Mixture

This study determined the effect of the oral and repeated administration of Fijk herbal mixture on rat biochemical and morphological parameters. Twenty-four Wistar rats were distributed into four groups of 6. Group A served as control and received oral administration of distilled water daily. The experimental groups B, C, and D were daily and orally exposed to Fijk herbal mixture at 15, 30, and 45 mg/kg, respectively. Treatments lasted for 21 days. The rats were sacrificed under mild diethyl ether anesthesia 24 hr after cessation of treatment. The blood and liver samples were collected and used for the biochemical and morphological analyses. Oral exposure to Fijk caused elevated levels of rat plasma ALT, AST, triglycerides, LDL, and MDA. In contrast, rat plasma HDL, GSH, and ALP levels were lowered by Fijk oral exposure. Also, the herbal remedy caused a dose-dependent elevation in the plasma atherogenic index. The histopathology examinations of rat liver sections revealed inimical cellular alterations caused by repeated exposure to Fijk. Study provides evidence that oral and repeated exposure to Fijk in rats raised the atherogenic index and potentiated oxidative stress as well as hepatic injury.

Hepatotoxicity and chromosomal abnormalities evaluation due to single and repeated oral exposures of chromium oxide nanoparticles in Wistar rats

2019 ◽  
Vol 35 (8) ◽  
pp. 548-557 ◽  
Author(s):  
Ravish Fatima ◽  
Riaz Ahmad
Keyword(s):  
Chromium Oxide ◽  
Wistar Rats ◽  
Chromosomal Abnormalities ◽  
Metal Oxide Nanoparticles ◽  
Toxicity Assessment ◽  
Industrial Applications ◽  
Oxide Nanoparticles ◽  
Safety Issues ◽  
Sperm Abnormalities ◽  
Transmission Electron

Metal oxide nanoparticles (NPs) have widespread uses ranging from nanoelectronics to nanotherapeutics. Because of their expanding industrial applications, a better understanding of their toxicity is needed. So far, limited reports are available on chromium oxide NPs (Cr2O3 NPs) toxicity. In this work, Cr2O3 NPs were synthesized and characterized in a sequential manner using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and transmission electron microscopy. Dose- and time-dependent toxicity assessment of Cr2O3 NPs was carried out in Wistar rats by examining liver function biomarkers, tissue histopathology, micronuclei (MN) formation, and chromosomal aberrations (CAs) in bone marrow along with sperm abnormalities. The results of this study demonstrated typical XRD and FTIR patterns of Cr2O3 NPs with a size of approximately 23.47 nm. Animals exposed to Cr2O3 NPs, exhibited a significant increase in aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma glutamyltransferase, and total bilirubin, signifying liver injury. Histopathology data also supported the marked alterations in the liver biochemistry of NPs-exposed animals. Further, an increase in the frequency of MN, CA, and sperm abnormalities suggested Cr2O3 NPs-mediated genotoxicity. It is, therefore, suggested that possible safety issues of Cr2O3 NPs should be addressed promptly with limited future use in occupational settings.

scholarly journals Modification of biochemical and haematological parameters during 90-days subchronic toxicity assessment of Carissa edulis in Wistar rats

2017 ◽  
Vol 9 (2) ◽  
pp. 7-13
Author(s):  
Razack Osseni ◽  
Etienne Adanle ◽  
Marius Adjagba ◽  
Awede Bonaventure ◽  
Tatiana Hountohotegbe ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Assessment ◽  
Haematological Parameters ◽  
Subchronic Toxicity

Effect of oral exposure to acrylamide on biochemical and hematologic parameters in Wistar rats

2018 ◽  
Vol 42 (2) ◽  
pp. 157-166 ◽  
Author(s):  
Abdelhammid Belhadj Benziane ◽  
Abdelkader Dilmi Bouras ◽  
Abdelkader Mezaini ◽  
Ahmed Belhadri ◽  
Mohammed Benali
Keyword(s):  
Wistar Rats ◽  
Oral Exposure

scholarly journals Biochemical changes after short-term oral exposure of Jatropha curcas seeds in wistar rats

2010 ◽  
Vol 17 (2) ◽  
pp. 67 ◽  
Author(s):  
Vijeyta Awasthy ◽  
VP Vadlamudi ◽  
KM Koley ◽  
BK Awasthy ◽  
PK Singh
Keyword(s):  
Jatropha Curcas ◽  
Wistar Rats ◽  
Biochemical Changes ◽  
Oral Exposure ◽  
Short Term
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