The early changes in mouse skin following topical application of a range of middle distillate oil products

1993 ◽  
Vol 13 (4) ◽  
pp. 247-257 ◽  
Author(s):  
A. J. Ingram ◽  
D. J. King ◽  
P. Grasso ◽  
M. Sharratt
Keyword(s):  
Topical Application ◽  
Mouse Skin ◽  
Oil Products ◽  
Middle Distillate

scholarly journals Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1627 ◽  
Author(s):  
Thiago A.F. Ferro ◽  
Eliene B. Souza ◽  
Mariela A.M. Suarez ◽  
João F.S. Rodrigues ◽  
Domingos M.S. Pereira ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Topical Application ◽  
Transient Receptor Potential ◽  
Bacterial Load ◽  
Unmet Need ◽  
Antimicrobial Properties ◽  
Mouse Skin ◽  
Interleukin 17 ◽  
Skin Wounds ◽  
Infected Skin

Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the major component of cinnamon oil, is well known for its antimicrobial properties. Herein, we investigated the effects of sub-inhibitory concentrations of cinnamaldehyde in the virulence of P. aeruginosa. We also assessed its healing potential in P. aeruginosa-infected mouse skin wounds and the mechanisms involved in this response. Sub-inhibitory concentrations of cinnamaldehyde reduced P. aeruginosa metabolic rate and its ability to form biofilm and to cause haemolysis. Daily topical application of cinnamaldehyde on P. aeruginosa-infected skin wounds reduced tissue bacterial load and promoted faster healing. Lower interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and nitric oxide levels were detected in cinnamaldehyde-treated wound samples. Blockage of transient receptor potential ankyrin 1, the pharmacological target of cinnamaldehyde, abrogated its healing activity and partially reversed the inhibitory actions of this compound on VEGF and IL-17 generation. We suggest that topical application of sub-inhibitory concentrations of cinnamaldehyde may represent an interesting approach to improve the healing of P. aeruginosa-infected skin wounds.

Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin

1992 ◽  
Vol 13 (6) ◽  
pp. 947-954 ◽  
Author(s):  
Mou-Tuan Huang ◽  
Chi-Tang Ho ◽  
Zhi Yuan Wang ◽  
Thomas Ferraro ◽  
Tara Finnegan-Olive ◽  
...  
Keyword(s):  
Green Tea ◽  
Topical Application ◽  
Mouse Skin ◽  
Inhibitory Effect ◽  
Tumor Initiation ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol

Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

1994 ◽  
Vol 15 (9) ◽  
pp. 2069-2071 ◽  
Author(s):  
Masaharu Asanoma ◽  
Kazuhiko Takahashi ◽  
Masaki Miyabe ◽  
Katsuhiko Yamamoto ◽  
Naoki Yoshimi ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Topical Application ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect ◽  
Two Stage

Carcinogenicity of 7H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo[a]pyrene in mouse skin and liver following topical application

Toxicology ◽  
1994 ◽  
Vol 93 (2-3) ◽  
pp. 135-149 ◽  
Author(s):  
David Warshawsky ◽  
William Barkley ◽  
Marian L. Miller ◽  
Kathy LaDow ◽  
Anastacia Andringa
Keyword(s):  
Topical Application ◽  
Mouse Skin

Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate

2008 ◽  
Vol 92 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Henriëtte S. de Bruijn ◽  
Carel Meijers ◽  
Angélique van der Ploeg – van den Heuvel ◽  
Henricus J.C.M. Sterenborg ◽  
Dominic J. Robinson
Keyword(s):  
Topical Application ◽  
Normal Mouse ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Mouse Skin
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