Phytoglycoprotein (150 kDa) isolated fromSolanum nigrumLinne has a preventive effect on dextran sodium sulfate-induced colitis in A/J mouse

2009 ◽  
Vol 29 (3) ◽  
pp. 207-213 ◽  
Author(s):  
Heon-Yeong Joo ◽  
Kwang Lim ◽  
Kye-Taek Lim
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Preventive Effect

scholarly journals The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Aleksandra Matuszyk ◽  
Dagmara Ceranowicz ◽  
Zygmunt Warzecha ◽  
Piotr Ceranowicz ◽  
Krzysztof Fyderek ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Sodium Sulfate ◽  
Colonic Mucosa ◽  
Body Weight Gain ◽  
Interleukin 1 ◽  
Mucosal Damage ◽  
Dextran Sodium Sulfate ◽  
Therapeutic Effects ◽  
Preventive Effect ◽  
Effect Of Treatment

Ghrelin has protective and therapeutic effects in the gut. The aim of present studies was to investigate the effect of treatment with ghrelin on the development of colitis evoked by dextran sodium sulfate (DSS). Methods. Studies have been performed on rats. Colitis was induced by adding 5% DSS to the drinking water for 5 days. During this period animals were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 8 nmol/kg/dose. On the sixth day, animals were anesthetized and the severity of colitis was assessed. Results. Treatment with ghrelin during administration of DSS reduced the development of colitis. Morphological features of colonic mucosa exhibited a reduction in the area and deep of mucosal damage. Ghrelin reversed the colitis-induced decrease in blood flow, DNA synthesis, and superoxide dismutase activity in colonic mucosa. These effects were accompanied by a decrease in the colitis-evoked increase in mucosal concentration of interleukin-1β and malondialdehyde. Treatment with ghrelin reversed the DSS-induced reduction in body weight gain. Conclusions. Administration of ghrelin exhibits the preventive effect against the development of DSS-induced colitis. This effect seems to be related to ghrelin’s anti-inflammatory and antioxidative properties.

Naringin protects against dextran sodium sulfate-induced colitis in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
E Giner ◽  
M Marin ◽  
C Recio ◽  
J Ríos ◽  
R Giner
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

Comparative effects of STW 5 and STW 5-II in dextran sodium sulfate-induced colitis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MT Khayyal ◽  
W Wadie ◽  
D Weiser ◽  
H Abdel-Aziz
Keyword(s):  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

scholarly journals Ethanol Extract ofCordyceps militarisGrown on Germinated Soybeans Attenuates Dextran-Sodium-Sulfate- (DSS-) Induced Colitis by Suppressing the Expression of Matrix Metalloproteinases and Inflammatory Mediators

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Dong Ki Park ◽  
Hye-Jin Park
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Mediators ◽  
Sodium Sulfate ◽  
Activity Index ◽  
Disease Activity Index ◽  
Ethanol Extract ◽  
Treated Group ◽  
Dextran Sodium Sulfate ◽  
Protective Agent ◽  
Colon Tissue

The effect ofCordyceps militaris(CM) grown on germinated soybeans (GSC) in the inflammatory bowel disease (IBD) model was studied. To demonstrate the preventive effect of GSC extract in a dextran-sodium-sulfate- (DSS-) induced acute colitis mouse model, GSC was administered 2 days before DSS coadministration. GSC significantly suppressed DSS-induced disease activity index (DAI) as well as histopathological scores, compared to control or CM-treated group. To elucidate the anti-IBD activity of GSC, we checked the level of matrix metalloproteinases (MMPs) and inflammatory mediators. GSC extract decreased the level of MMP-3 and -9 mRNAs and p53 proteins. The level and activity of LPS-induced MMP-9 were reduced in GSC-treated RAW264.7 cells. It also attenuated the level of inducible nitric oxide synthase (iNOS) and tumor necrosis factor- (TNF-)αmRNAs both in colon tissue and in macrophage cells. These results suggest that GSC can be applied as a protective agent against IBDs.

Sign in / Sign up

Export Citation Format

Share Document