Bi‐stability of the master gene regulatory network of the common dendritic precursor cell: Implications for cell differentiation

IUBMB Life ◽  
2020 ◽  
Vol 72 (10) ◽  
pp. 2225-2232
Author(s):  
Nayan De ◽  
Mintu Nandi ◽  
Suman Banik ◽  
Siddhartha Roy
Keyword(s):  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Precursor Cell ◽  
The Common ◽  
Gene Regulatory

scholarly journals A Gene Regulatory Network for Root Epidermis Cell Differentiation in Arabidopsis

PLoS Genetics ◽  
2012 ◽  
Vol 8 (1) ◽  
pp. e1002446 ◽  
Author(s):  
Angela Bruex ◽  
Raghunandan M. Kainkaryam ◽  
Yana Wieckowski ◽  
Yeon Hee Kang ◽  
Christine Bernhardt ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Root Epidermis ◽  
Gene Regulatory ◽  
Epidermis Cell

Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network

2014 ◽  
Vol 261 (1) ◽  
pp. 116-125 ◽  
Author(s):  
Kazuhiko Igarashi ◽  
Kyoko Ochiai ◽  
Ari Itoh-Nakadai ◽  
Akihiko Muto
Keyword(s):  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Plasma Cell ◽  
Regulatory Network ◽  
Plasma Cell Differentiation ◽  
Its Gene ◽  
Gene Regulatory

scholarly journals Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Carine Gubelmann ◽  
Petra C Schwalie ◽  
Sunil K Raghav ◽  
Eva Röder ◽  
Tenagne Delessa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Whole Body ◽  
Central Component ◽  
Fat Cell ◽  
Differentiation Potential ◽  
Adipogenic Gene ◽  
Gene Regulatory

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiation is centered on the transcriptional cascades driven by the C/EBP protein family and the master regulator PPARγ. To elucidate further components of the adipogenic gene regulatory network, we performed a large-scale transcription factor (TF) screen overexpressing 734 TFs in mouse pre-adipocytes and probed their effect on differentiation. We identified 22 novel pro-adipogenic TFs and characterized the top ranking TF, ZEB1, as being essential for adipogenesis both in vitro and in vivo. Moreover, its expression levels correlate with fat cell differentiation potential in humans. Genomic profiling further revealed that this TF directly targets and controls the expression of most early and late adipogenic regulators, identifying ZEB1 as a central transcriptional component of fat cell differentiation.

scholarly journals The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots

2016 ◽  
Vol 28 (12) ◽  
pp. 2937-2951 ◽  
Author(s):  
Luca Santuari ◽  
Gabino F. Sanchez-Perez ◽  
Marijn Luijten ◽  
Bas Rutjens ◽  
Inez Terpstra ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Gene Regulatory

EVIDENCE OF SCALE-FREE TOPOLOGY IN GENE REGULATORY NETWORK OF HUMAN TISSUES

2008 ◽  
Vol 19 (02) ◽  
pp. 283-290 ◽  
Author(s):  
M. ANDRECUT ◽  
S. A. KAUFFMAN ◽  
A. M. MADNI
Keyword(s):  
Gene Regulatory Network ◽  
Gene Regulatory Networks ◽  
Regulatory Network ◽  
Gene Network ◽  
Regulatory Networks ◽  
Regulatory Gene ◽  
Human Tissues ◽  
Scale Free ◽  
The Common ◽  
Gene Regulatory

We report the reconstruction of the topology of gene regulatory network in human tissues. The results show that the connectivity of the regulatory gene network is characterized by a scale-free distribution. This result supports the hypothesis that scale-free networks may represent the common blueprint for gene regulatory networks.

What is Hysteresis?

2011 ◽  
Vol 64 (5) ◽  
Author(s):  
K. A. Morris
Keyword(s):  
Magnetic Field ◽  
Gene Regulatory Network ◽  
Smart Materials ◽  
Regulatory Network ◽  
Final Section ◽  
Input Output ◽  
Common Features ◽  
The Common ◽  
Gene Regulatory ◽  
Periodic Inputs

Hysteresis is a widely occurring phenomenon. It can be found in a wide variety of natural and constructed systems. Generally, a system is said to exhibit hysteresis when a characteristic looping behavior of the input-output graph is displayed. These loops can be due to a variety of causes. Furthermore, the input-output graphs of periodic inputs at different frequencies are generally identical. Existing definitions of hysteresis are useful in different contexts but fail to fully characterize it. In this paper, a number of different situations exhibiting hysteresis are described and analyzed. The applications described are: an electronic comparator, gene regulatory network, backlash, beam in a magnetic field, a class of smart materials and inelastic springs. The common features of these widely varying situations are identified and summarized in a final section that includes a new definition for hysteresis.

scholarly journals A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers

2016 ◽  
Vol 7 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Satoshi Okawa ◽  
Sarah Nicklas ◽  
Sascha Zickenrott ◽  
Jens C. Schwamborn ◽  
Antonio del Sol
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Gene Regulatory Network ◽  
Network Model ◽  
Regulatory Network ◽  
Stem Cell Differentiation ◽  
Gene Regulatory
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