scholarly journals Epigenetic role of CCAAT box-binding transcription factor NF-Y onIDgene family in human embryonic carcinoma cells

IUBMB Life ◽  
2015 ◽  
Vol 67 (11) ◽  
pp. 880-887 ◽  
Author(s):  
Farideh Moeinvaziri ◽  
Maryam Shahhoseini
Keyword(s):  
Transcription Factor ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells ◽  
Ccaat Box

Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells

FEBS Letters ◽  
2014 ◽  
Vol 588 (17) ◽  
pp. 3129-3136 ◽  
Author(s):  
Sung-Won Park ◽  
Hyun-Jin Do ◽  
Woo Tae Ha ◽  
Mi-Hee Han ◽  
Keun-Hong Park ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcriptional Activation ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells ◽  
Ets Transcription Factor

scholarly journals ShRNA-mediated gene silencing of AHR promotes the differentiation of P19 mouse embryonic carcinoma cells into cardiomyocytes

2012 ◽  
Vol 6 (3) ◽  
pp. 513-518 ◽  
Author(s):  
CHUN ZHU ◽  
YU-LIN CHEN ◽  
XUE-JIE WANG ◽  
XIAO-SHAN HU ◽  
ZHANG-BIN YU ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells

scholarly journals Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2

2019 ◽  
Vol 20 (9) ◽  
pp. 2071 ◽  
Author(s):  
Mengying Yu ◽  
Lei Zhang ◽  
Yingxiang Liu ◽  
Defu Liu ◽  
Zekun Guo
Keyword(s):  
Retinoic Acid ◽  
Cell Differentiation ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Embryonic Carcinoma ◽  
Extracellular Signal ◽  
Embryonic Carcinoma Cells ◽  
Embryonic Carcinoma Cell ◽  
Mediate Cell

Retinoic acid (RA) plays a key role in pluripotent cell differentiation. In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Here, we show that miR-485 is a positive regulator that targets α/β-hydrolase domain-containing protein 2 (Abhd2), which can result in Erk1/2 phosphorylation and triggers differentiation. RA up-regulates miR-485 and concurrently down-regulates Abhd2. We verified that Abhd2 is targeted by miR-485 and they both can influence the phosphorylation of Erk1/2. In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.

Sign in / Sign up

Export Citation Format

Share Document