scholarly journals Local advanced adrenocortical cancer with a long‐term recurrence‐free survival treated with complete surgical excision and adjuvant therapy with a very low‐dose mitotane

2020 ◽  
Vol 3 (6) ◽  
pp. 233-235 ◽  
Author(s):  
Yuumi Tokura ◽  
Minoru Kobayashi ◽  
Takao Kamai
Keyword(s):  
Adjuvant Therapy ◽  
Low Dose ◽  
Surgical Excision ◽  
Recurrence Free Survival ◽  
Adrenocortical Cancer ◽  
Free Survival ◽  
Complete Surgical Excision ◽  
Local Advanced

scholarly journals Long-term recurrence-free survival of adrenocortical cancer extending into the inferior vena cava and right atrium

Medicine ◽  
2017 ◽  
Vol 96 (18) ◽  
pp. e6751 ◽  
Author(s):  
Abdulaziz Alghulayqah ◽  
Naif Alghasab ◽  
Tarik Amin ◽  
Nora Alkahtani ◽  
Rafif Farhat ◽  
...  
Keyword(s):  
Inferior Vena Cava ◽  
Right Atrium ◽  
Inferior Vena ◽  
Vena Cava ◽  
Recurrence Free Survival ◽  
Adrenocortical Cancer ◽  
Free Survival

scholarly journals Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases

1997 ◽  
Vol 2 (4) ◽  
pp. E5 ◽  
Author(s):  
Lucio Palma ◽  
Paolo Celli ◽  
Carmine Franco ◽  
Luigi Cervoni ◽  
Giampaolo Cantore
Keyword(s):  
Surgical Excision ◽  
Atypical Meningioma ◽  
Recurrence Free Survival ◽  
Malignant Meningioma ◽  
Histological Findings ◽  
Free Survival ◽  
Simpson Grade ◽  
Time To Recurrence ◽  
Atypical Meningiomas

To contribute to a better understanding of the prognostic differences between atypical and malignant meningiomas as defined by the World Health Organization (WHO) and the influence of the grade of initial surgical excision on postoperative course, 42 cases of atypical and 29 of malignant meningioma were studied, along with long-term follow up. The two groups were compared with respect to long-term survival, recurrence-free survival, and median time to recurrence. The prognostic significance of the Simpson grade of surgical resection and tumor location was also considered. Survival at 5 and 10 years was recorded in 95% and 79%, respectively, of patients with atypical meningioma and in 64.3% and 34.5% of patients with malignant meningioma (p = 0.001). Recurrence-free survival and median time to recurrence were also significantly longer in patients with atypical than in those with malignant meningiomas: 11.9 versus 2 years (p = 0.001) and 5 versus 2 years (p < 0.0041), respectively. Six (26%) of the 23 recurring atypical meningiomas became malignant. Simpson Grade I resection and location in the cerebral convexity, which were closely related, were found to be associated with a significantly better clinical course in the entire series (p ¾ 0.0016). Patients with atypical meningiomas fared better than those with malignant meningiomas after incomplete surgical excision (Simpson Grades II-III), but the difference was not statistically significant. Multivariate analysis using the Cox model indicated that radical extirpation (Simpson Grade I vs. II-III) and histological findings (atypical meningioma vs. malignant meningioma) were significantly related to prolonged survival (p < 0.0003 and p < 0.0388, respectively). In conclusion, the current study shows that for most patients with atypical meningioma the prognosis was less severe than for those with malignant meningioma, but the risk of a downhill course resulting from malignancy after incomplete resection and recurrence was not negligible (26%). In addition, the WHO classification was found to be inadequate for a minority of the atypical meningioma cases, which currently have the same unfavorable course as cases of malignant meningioma. The results also indicate that objective Simpson Grade I extirpation of convexity meningiomas can be successful despite histological findings of malignancy.

A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma.

1989 ◽  
Vol 7 (3) ◽  
pp. 355-366 ◽  
Author(s):  
P R Rosen ◽  
S Groshen ◽  
P E Saigo ◽  
D W Kinne ◽  
S Hellman
Keyword(s):  
Breast Carcinoma ◽  
Adjuvant Therapy ◽  
Stage I ◽  
Axillary Lymph ◽  
Recurrence Free Survival ◽  
Axillary Lymph Node Metastases ◽  
Term Survival ◽  
Free Survival

This study was undertaken to investigate the long-term survival and the probability of "cure" in a group of 644 patients treated by mastectomy for T1 breast carcinoma. After a median follow-up of 18.2 years, 23% were dead of recurrent breast carcinoma, 3% were alive with recurrent disease, and 74% had not experienced a recurrence. The probability of recurrence was directly related to the initial extent of the disease. Overall, 16% of recurrences and 25% of deaths due to disease occurred in the second decade of follow-up. The proportion of recurrences detected in the second decade was inversely related to the stage of the primary tumor at diagnosis. When stratified by tumor size, T1N0M0 patients with tumors 1.0 cm or less in diameter had a significantly better 20-year recurrence-free survival (86%) than did T1N0M0 patients with tumors 1.1 to 2.0 cm (69%). When observed and expected survival curves were compared by the method of Brinkley and Haybittle, it appeared that 80% of T1N0M0 patients with tumors 1 cm or less might be cured at 20 years, whereas for those in the 1.1- to 2-cm group, the proportion cured was indeterminate, but might be as high as 70%. A potentially cured group could not be identified among T1N1M0 patients, but an estimated 52% of these patients did not have a recurrence within the nearly 20-year follow-up period. These data are important when one considers the proper role of adjuvant therapy for stage I disease. Patients with tumors larger than 1 cm and those with axillary lymph node metastases may have an improved recurrence-free survival as a result of systemic adjuvant treatment, while women in the T1N0M0 group with an especially favorable recurrence-free survival, particularly those with tumors 1 cm in diameter or smaller, might be spared adjuvant therapy.

Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases

1997 ◽  
Vol 86 (5) ◽  
pp. 793-800 ◽  
Author(s):  
Lucio Palma ◽  
Paolo Celli ◽  
Carmine Franco ◽  
Luigi Cervoni ◽  
Giampaolo Cantore
Keyword(s):  
Surgical Excision ◽  
Atypical Meningioma ◽  
Recurrence Free Survival ◽  
Malignant Meningioma ◽  
Histological Findings ◽  
Free Survival ◽  
Simpson Grade ◽  
Time To Recurrence ◽  
Atypical Meningiomas

✓ To contribute to a better understanding of the prognostic differences between atypical and malignant meningiomas as defined by the World Health Organization (WHO) and the influence of the grade of initial surgical excision on postoperative course, 42 cases of atypical and 29 of malignant meningioma were studied, along with long-term follow up. The two groups were compared with respect to long-term survival, recurrence-free survival, and median time to recurrence. The prognostic significance of the Simpson grade of surgical resection and tumor location was also considered. Survival at 5 and 10 years was recorded in 95% and 79%, respectively, of patients with atypical meningioma and in 64.3% and 34.5% of patients with malignant meningioma (p = 0.001). Recurrence-free survival and median time to recurrence were also significantly longer in patients with atypical than in those with malignant meningiomas: 11.9 versus 2 years (p = 0.001) and 5 versus 2 years (p < 0.0041), respectively. Six (26%) of the 23 recurring atypical meningiomas became malignant. Simpson Grade I resection and location in the cerebral convexity, which were closely related, were found to be associated with a significantly better clinical course in the entire series (p ≤ 0.0016). Patients with atypical meningiomas fared better than those with malignant meningiomas after incomplete surgical excision (Simpson Grades II–III), but the difference was not statistically significant. Multivariate analysis using the Cox model indicated that radical extirpation (Simpson Grade I vs. II–III) and histological findings (atypical meningioma vs. malignant meningioma) were significantly related to prolonged survival (p < 0.0003 and p < 0.0388, respectively). In conclusion, the current study shows that for most patients with atypical meningioma the prognosis was less severe than for those with malignant meningioma, but the risk of a downhill course resulting from malignancy after incomplete resection and recurrence was not negligible (26%). In addition, the WHO classification was found to be inadequate for a minority of the atypical meningioma cases, which currently have the same unfavorable course as cases of malignant meningioma. The results also indicate that objective Simpson Grade I extirpation of convexity meningiomas can be successful despite histological findings of malignancy.

scholarly journals Long-term recurrence-free survival in a patient with stage IVB uterine carcinosarcoma

2011 ◽  
Vol 22 (4) ◽  
pp. 292 ◽  
Author(s):  
Gun Yoon ◽  
Yong-Seok Kim ◽  
Byoung-Gie Kim ◽  
Duk-Soo Bae ◽  
Jeong-Won Lee
Keyword(s):  
Recurrence Free Survival ◽  
Uterine Carcinosarcoma ◽  
Free Survival ◽  
Stage Ivb

scholarly journals Impact of postoperative complications on long-term survival of hepatocellular carcinoma patients after liver resection

2021 ◽  
Author(s):  
Susumu Mochizuki ◽  
Hisashi Nakayama ◽  
Yutaka Midorikawa ◽  
Tokio Higaki ◽  
Masamichi Moriguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Liver Resection ◽  
Pleural Effusion ◽  
Postoperative Complications ◽  
Recurrence Free Survival ◽  
Term Survival ◽  
Free Survival ◽  
Long Term Survival

Objective The effect of postoperative complications including red blood transfusion (BT) on long-term survival for hepatocellular carcinoma (HCC) is unknown. The purpose of this study was to define the relationship between postoperative complications and long-term survival in patients with HCC. Methods Postoperative complications of 1251 patients who underwent curative liver resection for HCC were classified, and their recurrence-free survival (RFS) and cumulative overall survival (OS) were investigated. Results Any complications occurred in 503 patients (40%). Five-year RFS and 5-year OS in the complication group were 21% and 56%, respectively, significantly lower than the respective values of 32% ( p &lt; 0.001) and 68% ( p &lt; 0.001) in the no-complication group (n=748). Complications related to RFS were postoperative BT [Hazard ratio (HR): 1.726, 95% confidence interval (CI): 1.338–2.228, p &lt; 0.001], pleural effusion [HR: 1.434, 95% CI: 1.200–1.713, p &lt; 0.001] using Cox-proportional hazard model. Complications related to OS were postoperative BT [HR: 1.843, 95%CI: 1.380-2.462, p &lt; 0.001], ascites [HR: 1.562, 95% CI: 1.066–2.290 p = 0.022], and pleural effusion [HR: 1.421, 95% CI: 1.150–1.755, p = 0.001). Conclusions Postoperative complications were factors associated with poor long-term survival. Postoperative BT and pleural effusion, were noticeable complications that were prognostic factors for both recurrence-free survival and overall survival.

Unusual presentation of granular cell tumour of buccal mucosa

2021 ◽  
Vol 14 (9) ◽  
pp. e242242
Author(s):  
Zhi Yon Charles Toh ◽  
Thomas Cooper ◽  
Maryam Jessri ◽  
Frank S-C Chang
Keyword(s):  
Buccal Mucosa ◽  
Correct Diagnosis ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumour ◽  
Granular Cell Tumour ◽  
Complete Surgical Excision ◽  
Uncommon Presentation ◽  
Long Term Follow Up

Granular cell tumour (GCT) is a rare soft tissue lesion which many consider to have malignant potential of yet unknown aetiopathogenesis. Oral GCT lesions may occur in an area of leucoplakia and are predominantly present on the tongue. This case study highlights an uncommon presentation of this condition located on the buccal mucosa and illustrates the need for meticulous evaluation of suspicious lesions. Due to the malignant risk associated with GCT lesions, it is important to make the correct diagnosis and ensure complete surgical excision for these cases. Ongoing long-term follow-up is also indicated to monitor for recurrence or malignancy.

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