Fetal bone mineralization defects following maternal inadvertent exposure to thiazolidinediones in pregnancy

2020 ◽  
Vol 149 (3) ◽  
pp. 379-380
Author(s):  
Mohd Ashraf Ganie ◽  
Aishwarya Krishnamurthy ◽  
Mohammad Salem ◽  
Aafia Rashid ◽  
Imtiaz Ahmad Wani ◽  
...  
Keyword(s):  
Bone Mineralization ◽  
Fetal Bone ◽  
In Pregnancy

Maternal Calcium Supplementation and Fetal Bone Mineralization

1999 ◽  
Vol 94 (4) ◽  
pp. 577-582 ◽  
Author(s):  
WINSTON W. K. KOO ◽  
JOCELYN C. WALTERS ◽  
JOY ESTERLITZ ◽  
RICHARD J. LEVINE ◽  
ANDREW J. BUSH ◽  
...  
Keyword(s):  
Bone Mineralization ◽  
Calcium Supplementation ◽  
Fetal Bone

Vitamins for the First 1000 Days: Preparing for Life

2012 ◽  
Vol 82 (5) ◽  
pp. 342-347 ◽  
Author(s):  
Ibrahim Elmadfa ◽  
Alexa L. Meyer
Keyword(s):  
Vitamin D ◽  
Folic Acid ◽  
Young Children ◽  
Pregnant Women ◽  
Bone Mineralization ◽  
Type I ◽  
Lactation Performance ◽  
Balanced Diet ◽  
Diabetes Mellitus Type I ◽  
In Pregnancy

Vitamins are essential nutrients for many body functions and particularly important during growth. Adequate supply in pregnancy and in early infancy is therefore crucial, but there is still a lack of knowledge about the needed amounts of vitamins of children older than six months and also during pregnancy. Recommendations for intake levels are generally derived by extrapolation from data for infants based in turn on the contents in breast milk and those for adults. A vitamin of particular importance in pregnancy is folic acid due to its role in the development of the brain and nerve system and the prevention of fetal neural tube defects (NTD). Mandatory fortification of flour and certain other grain products in many countries has been associated with a reduction in NTD incidence. However, other deficiencies or suboptimal status of B vitamins, especially B6 and B12 have been repeatedly reported in pregnant women also in high-income countries. Vitamin A is one of the three most critical micronutrients globally and pregnant women and young children are especially vulnerable to deficiencies. Night blindness, anemia, and immunodeficiency are major consequences of inadequate supply in these populations. Much attention has recently been accorded vitamin D that is also critical in pregnant women and young children for instance because of its involvement in bone mineralization but also its more recently discovered immune-modulating function that is thought to prevent development of autoimmune diseases like diabetes mellitus type I. A healthy balanced diet provides the best basis for optimal pregnancy outcome, lactation performance, and complementary feeding. However, supplements or fortified foods may be needed to cover the high requirements especially of critical vitamins such as vitamin D and folic acid and to correct unfavorable dietary patterns in women or to adapt foods to the needs of young children.

scholarly journals Effect of Chronic Maternal Calcium (Ca) Supplementation on Fetal Bone Mineralization (FBM). † 1535

1998 ◽  
Vol 43 ◽  
pp. 262-262
Author(s):  
Winston Koo ◽  
Jocelyn Walters ◽  
Andrew Bush ◽  
Joy Esterlitz ◽  
Baha Sibai ◽  
...  
Keyword(s):  
Bone Mineralization ◽  
Fetal Bone

scholarly journals Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years

2020 ◽  
Vol 174 (5) ◽  
pp. 419 ◽  
Author(s):  
Nicklas Brustad ◽  
Juri Garland ◽  
Jonathan Thorsen ◽  
Astrid Sevelsted ◽  
Martin Krakauer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineralization ◽  
Standard Dose ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
In Pregnancy

scholarly journals Factors affecting newborn bone mineral content: in utero effects on newborn bone mineralization

2000 ◽  
Vol 59 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Ran Namgung ◽  
Reginald C. Tsang
Keyword(s):  
Vitamin D ◽  
Bone Formation ◽  
Mineral Content ◽  
Bone Mineralization ◽  
Newborn Infants ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Fetal Bone ◽  
Cord Serum ◽  
Total Body

Several factors have been found recently to have a significant impact on newborn bone mineral content (BMC) and developing fetal bone. Recently we showed that maternal vitamin D deficiency may affect fetal bone mineralization. Korean winter-born newborn infants had extremely low serum 25-hydroxyvitamin D (25-OHD), high serum cross-linked carboxy-terminal telopeptide of type I collagen (ICTP; a bone resorption marker), and markedly lower (8 %) total body BMC than summer-born newborn infants. Infant total body BMC was positively correlated with cord serum 25-OHD and inversely correlated with ICTP, which was also negatively correlated with vitamin D status. In three separate studies on North American neonates we found markedly lower (8–12 %) BMC in summer newborn infants compared with winter newborn infants, the opposite of the findings for Korean neonates. The major reason for the conflicting BMC results might be the markedly different maternal vitamin D status of the North American and Korean subjects. Recently, we found evidence of decreased bone formation rates in infants who were small-for-gestational age (SGA) compared with infants who were appropriate-for-gestational age; we reported reduced BMC, cord serum osteocalcin (a marker of bone formation) and 1,25-dihydroxyvitamin D (the active metabolite of vitamin D), but no alterations in indices of fetal bone collagen metabolism. In theory, reduced utero-placental blood flow in SGA infants may result in reduced transplacental mineral supply and reduced fetal bone formation. Infants of diabetic mothers (IDM) have low BMC at birth, and infant BMC correlated inversely with poor control of diabetes in the mother, specifically first trimester maternal mean capillary blood glucose concentration, implying that factors early in pregnancy might have an effect on fetal BMC. The low BMC in IDM may be related to the decreased transplacental mineral transfer. Cord serum ICTP concentrations were higher in IDM than in control subjects, implying increased intrauterine bone resorption. BMC is consistently increased with increasing body weight and length in infants. Race and gender differences in BMC appear in early life, but not at birth. Ethanol consumption and smoking by the mother during pregnancy affect fetal skeletal development.

Levetiracetam Induced Acute Pancreatitis Case in Pregnancy

2013 ◽  
Vol 40 (06) ◽  
pp. 896 ◽  
Author(s):  
Murat Sarikaya ◽  
Nesibe Taser ◽  
Zeynal Dogan ◽  
Bilal Ergul ◽  
F. Irsel Tezer ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
In Pregnancy
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