Effect of extended oral contraception use on the prevalence of fetal trisomy 21 in women aged at least 35 years

2017 ◽  
Vol 138 (3) ◽  
pp. 261-266 ◽  
Author(s):  
Dániel Horányi ◽  
Lilla Éva Babay ◽  
János Rigó ◽  
Balázs Győrffy ◽  
Gyula R. Nagy
Keyword(s):  
Trisomy 21 ◽  
Oral Contraception ◽  
Contraception Use

scholarly journals Erratum to “Effect of extended oral contraception use on the prevalence of fetal trisomy 21 in women aged at least 35 years”

2018 ◽  
Vol 140 (2) ◽  
pp. 258-258 ◽  
Author(s):  
Dániel Horányi ◽  
Lilla Éva Babay ◽  
János Rigó ◽  
Balázs Győrffy ◽  
Gyula R. Nagy
Keyword(s):  
Trisomy 21 ◽  
Oral Contraception ◽  
Contraception Use

Determinants of oral contraception use in a southern European setting

2010 ◽  
Vol 15 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Gloria Pérez ◽  
Rodrigo Villegas ◽  
Dolors Ruiz-Muñoz ◽  
Maica Rodríguez-Sanz
Keyword(s):  
Oral Contraception ◽  
Contraception Use

scholarly journals A terhességet megelőzően alkalmazott hosszabb távú orális fogamzásgátlás mint a magzati 21-es triszómia lehetséges kockázatcsökkentő tényezője idős anyai életkorban vállalt terhességben

2018 ◽  
Vol 159 (28) ◽  
pp. 1146-1152
Author(s):  
Dániel Horányi ◽  
Lilla Éva Babay ◽  
Balázs Győrffy ◽  
Gyula Richárd Nagy
Keyword(s):  
Down Syndrome ◽  
Chromosomal Abnormality ◽  
Trisomy 21 ◽  
Maternal Age ◽  
Genetic Disorder ◽  
Advanced Maternal Age ◽  
Oral Contraception ◽  
Summary Report ◽  
Meiotic Nondisjunction

Abstract: Down syndrome is the most common autosomal chromosomal abnormality. According to the classical interpretation, it is the result of meiotic nondisjunction. Its occurrence is more common in advanced maternal age. Despite intensive research, pathophysiology of this genetic disorder is not fully understood. According to recent studies, a different kind of mechanism may be found in the background of trisomy 21 than was previously considered. Based on the ovarian mosaicism model, the cause of trisomy 21 (or any common trisomy) is a segregation error of a chromosome in premeiotic mitosis. The cell entering meiosis will be an oocyte with preexisting trisomy, where its (so-called “secondary”) nondisjunction is essential. Maturation of the trisomic oocytes appears to fall behind the disomic oocytes, resulting in their relative accumulation in the ovaries as time progresses. The ratio of trisomic/disomic cells becomes less favorable in maternal maturity. If ovulation is inhibited – although the number of oocytes will continue to decline due to apoptosis – it can be assumed that the trisomic/disomic oocyte ratio remains more favorable with the progression of age. In our summary report, presenting and updating our previous data, we would like to propose that – according to ovarian mosaicism model – long-term oral contraception in the anamnesis may be beneficial in pregnancies with advanced maternal age. Orv Hetil. 2018; 159(28): 1146–1152.

scholarly journals Oral Contraception Use in Benign Breast Tumor Patients in Dr. Soetomo General Academic Hospital

2019 ◽  
Vol 3 (12) ◽  
pp. 467-470
Author(s):  
Ayu Maghfira Nida Putri ◽  
Sjahjenny Mustokoweni ◽  
Ernawati Ernawati
Keyword(s):  
Breast Tumor ◽  
Average Length ◽  
Hormonal Contraception ◽  
Breast Tumors ◽  
Oral Contraception ◽  
Benign Tumors ◽  
Academic Hospital ◽  
Benign Breast Tumor ◽  
Contraception Use ◽  
Benign Breast Tumors

The growth of breast tumors is influenced by estrogen and progesterone hormones. One source of this hormone is hormonal contraception, including oral contraception which still in demand by Indonesian women. This study wants to identify oral contraception use in patients with benign breast tumors. This used descriptive study with a retrospective cross-sectional design. Samples were taken using the total sampling method in patients with benign breast tumors according to ICD 10 D-24 which was confirmed by FNAB examination at the POSA Dr. Soetomo General Academic Hospital between 2015-2017. Fifty three case of benign breast tumor were found with dominant characteristics at the age of group 40-49 years old (47.2%), had a breastfeeding history (50.9%), multiparous woman(64.2%), mean of menarche age at 13.28 years old and fertile periode women (83.0%). The most common type of benign tumors found were fibrocystic change. Patients who used oral contraceptives were 24.5% with an average length of use for 8 years 2 months, while another 75.5% used non-hormonal contraception or did not use any contraception. So the conclusion is majority of patients with benign breast tumors do not use oral contraception. Keywords: benign breast tumor; oral contraception; estrogen

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