scholarly journals Genetic polymorphisms in the cag pathogenicity island of Helicobacter pylori and risk of stomach cancer and high‐grade premalignant gastric lesions

2020 ◽  
Vol 147 (9) ◽  
pp. 2437-2445 ◽  
Author(s):  
Federico Canzian ◽  
Cosmeri Rizzato ◽  
Ofure Obazee ◽  
Angelika Stein ◽  
Lourdes Flores‐Luna ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Stomach Cancer ◽  
Genetic Polymorphisms ◽  
Pathogenicity Island ◽  
High Grade ◽  
Gastric Lesions ◽  
Cag Pathogenicity Island

scholarly journals The organization of Helicobacter pylori cag-pathogenicity island (cagPAI) genes in multiracial population with histopathological changes of gastric mucosa

2019 ◽  
Author(s):  
Alfizah Hanafiah ◽  
Shaza Azlin Razak ◽  
Hui-min Neoh ◽  
Noraziah Mohamad Zin ◽  
Bruno S. Lopes
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Pathogenicity Island ◽  
Type Iv Secretion ◽  
Virulence Determinants ◽  
Gastric Diseases ◽  
Cag Pathogenicity Island ◽  
Type Iv ◽  
Inflammatory Score ◽  
H Pylori

Abstract Background: Helicobacter pylori is a Gram-negative bacillus that colonises only the mucus layer of the human stomach and is implicated in gastric diseases. Virulent H. pylori harbouring cag-pathogenicity island (cagPAI) which encodes genes for type IV secretion system (T4SS) and CagA protein is one of the major virulence determinants involved in disease development. We examined the entire cagPAI genes in 95 H. pylori isolates from a multiracial population and examined the intactness of cagPAI region with histopathological scores of the gastric mucosa. Results: 95.8% of H. pylori isolates were cagPAI-positive with 23.2% having an intact cagPAI, whereas 72.6% had a partial/rearranged cagPAI. In our study, cag2 and cag4 were found to be significantly higher in H. pylori isolated from Malays, whereas cag4 was predominant in Chinese isolates. We also detected cag24 in significantly high proportion in isolates from the Malays and the Indians compared to the Chinese isolates. The intactness of cagPAI region showed an association with histopathological scores of the gastric mucosa. Significant association was observed between H. pylori harbouring partial cagPAI and higher density of H. pylori and neutrophil activity, whereas strains which lacked cagPAI was associated with higher inflammatory score. Conclusions: The screening of the entire cagPAI genes provides an accurate overview of the cagPAI organisation in H. pylori isolates in a multiracial population. The genotypes of H. pylori strains with various cagPAI rearrangement associated with patients’ ethnicities and histopathological scores might contribute to the pathogenesis of H. pylori infection in a multi-ethnic population.

Status of Helicobacter pylori cag pathogenicity island ( cag PAI) integrity and significance of its individual genes

2018 ◽  
Vol 59 ◽  
pp. 167-171 ◽  
Author(s):  
Rumyana Markovska ◽  
Lyudmila Boyanova ◽  
Daniel Yordanov ◽  
Petya Stankova ◽  
Galina Gergova ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pathogenicity Island ◽  
Cag Pathogenicity Island ◽  
Cag Pai

IL-8 response by Japanese Helicobacter pylori strains with different cag pathogenicity island structures

1998 ◽  
Vol 114 ◽  
pp. A210
Author(s):  
S Maeda ◽  
T Ikenoue ◽  
K Ogura ◽  
H Yoshida ◽  
F Kanai ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pathogenicity Island ◽  
Cag Pathogenicity Island

The Mouse Colonizing Helicobacter pylori Strain SS1 May Lack a Functional cag Pathogenicity Island

Helicobacter ◽  
2002 ◽  
Vol 7 (2) ◽  
pp. 139-140 ◽  
Author(s):  
Jean E. Crabtree ◽  
Richard L. Ferrero ◽  
Johannes G. Kusters
Keyword(s):  
Helicobacter Pylori ◽  
Pathogenicity Island ◽  
Cag Pathogenicity Island

scholarly journals Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8

2003 ◽  
Vol 47 (6) ◽  
pp. 1759-1759 ◽  
Author(s):  
Wolfgang Fischer ◽  
Jürgen Püls ◽  
Renate Buhrdorf ◽  
Bettina Gebert ◽  
Stefan Odenbreit ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pathogenicity Island ◽  
Essential Genes ◽  
Interleukin 8 ◽  
Host Cells ◽  
Cag Pathogenicity Island

The Helicobacter pylori Cag Pathogenicity Island Protein Cag1 is Associated with the Function of T4SS

2016 ◽  
Vol 73 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Xiaochun Wang ◽  
Feng Ling ◽  
Hua Wang ◽  
Min Yu ◽  
Hong Zhu ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Pathogenicity Island ◽  
Cag Pathogenicity Island
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