scholarly journals Development and validation of a five‐gene model to predict postoperative brain metastasis in operable lung adenocarcinoma

2020 ◽  
Vol 147 (2) ◽  
pp. 584-592
Author(s):  
Fangqiu Fu ◽  
Yang Zhang ◽  
Zhendong Gao ◽  
Yue Zhao ◽  
Zhexu Wen ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Lung Adenocarcinoma ◽  
Gene Model ◽  
Development And Validation

Micropapillary predominance is a risk factor for brain metastasis in resected lung adenocarcinoma

2021 ◽  
Author(s):  
Takao Shigenobu ◽  
Yusuke Takahashi ◽  
Yohei Masugi ◽  
Ryutaro Hanawa ◽  
Hirokazu Matsushita ◽  
...  
Keyword(s):  
Risk Factor ◽  
Brain Metastasis ◽  
Lung Adenocarcinoma

scholarly journals Combining Carcinoembryonic Antigen and Platelet to Lymphocyte Ratio to Predict Brain Metastasis of Resected Lung Adenocarcinoma Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Wei Wang ◽  
Chao Bian ◽  
Di Xia ◽  
Jin-Xi He ◽  
Ping Hai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Metastasis ◽  
Lung Adenocarcinoma ◽  
Carcinoembryonic Antigen ◽  
Roc Curve ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Increased Risk

We aimed to evaluate the role of pretreatment carcinoembryonic antigen (CEA) and platelet to lymphocyte ratio (PLR) in predicting brain metastasis after radical surgery for lung adenocarcinoma patients. The records of 103 patients with completely resected lung adenocarcinoma between 2013 and 2014 were reviewed. Clinicopathologic characteristics of these patients were assessed in the Cox proportional hazards regression model. Brain metastasis occurred in 12 patients (11.6%). On univariate analysis, N2 stage (P = 0.013), stage III (P = 0.016), increased CEA level (P = 0.006), and higher PLR value (P = 0.020) before treatment were associated with an increased risk of developing brain metastasis. In multivariate model analysis, CEA above 5.2 ng/mL (P = 0.014) and PLR ≥ 120 (P = 0.036) remained as the risk factors for brain metastasis. The combination of CEA and PLR was superior to CEA or PLR alone in predicting brain metastasis according to the receiver operating characteristic (ROC) curve analysis (area under ROC curve, AUC 0.872 versus 0.784 versus 0.704). Pretreatment CEA and PLR are independent and significant risk factors for occurrence of brain metastasis in resected lung adenocarcinoma patients. Combining these two factors may improve the predictability of brain metastasis.

scholarly journals Development and validation of a prediction model for lung adenocarcinoma based on RNA-binding protein

2021 ◽  
Vol 9 (6) ◽  
pp. 474-474
Author(s):  
Longjun Yang ◽  
◽  
Rusi Zhang ◽  
Guangran Guo ◽  
Gongming Wang ◽  
...  
Keyword(s):  
Prediction Model ◽  
Lung Adenocarcinoma ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Development And Validation

scholarly journals CMET-30. COMPREHENSIVE METHYLOME ANALYSIS OF EGFR-MUTANT PRIMARY LUNG ADENOCARCINOMA AND MATCHED BRAIN METASTASIS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi58-vi58
Author(s):  
Yasin Mamatjan ◽  
Michael Cabanero ◽  
Jeffrey Zuccato ◽  
Jessica Weiss ◽  
Shirin Karimi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Brain Metastasis ◽  
Lung Adenocarcinoma ◽  
Immune Cell ◽  
Methylation Status ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Promoter Regions ◽  
Primary Lung Adenocarcinoma ◽  
Egfr Mutant

Abstract Brain metastasis (BM) in patients with EGFR-mutant lung adenocarcinoma is a major determinant of overall survival. Novel insight into the genetic and epigenetic underpinnings of BM development is lacking. The aim of this study is to compare the methylome of EGFR-mutant primary lung adenocarcinoma (EGFRM-PLA) and matched BM to identify important alterations for the mechanisms of BM. Matched EGFRM-PLA and BM tumors from seven patients were profiled using the Illumina Infinium MethylationEPIC BeadChip array. Unsupervised clustering analyses of the 14 samples showed a similar whole DNA methylation signatures between EGFRM-PLA and BM tumors. Furthermore, PCA plot highlighted that seven matched BM and lung tumor samples were clustered together closely based on matching pairs for the most variable probes (2.5K to 10K). These observations indicate high level of concordance and the same cell of origin. However, these fourteen samples clustered into two groups based on tumor site being lung or brain based on 83K differentially methylated CpG sites. Of the 83K probes, 2.4K were either hypermethylated or hypomethylated in all lung samples. A quarter of these 2.4K probes were located in promoter regions. Specifically, we identified differences in methylation status of EGFR/ALK promoter regions in lung tumors versus BM. CNV analyses showed higher deep deletions of chromosomes and genes in BM compared to EGFRM-PLA. Leukocytes unmethylation for purity (LUMP) scores which indicate immune cell infiltration were similar between lung and BM pairs (Mean LUMP_score=0.64) consistent with high immune cell infiltration. Our results indicated a similar whole DNA methylation signature of EGFRM-PLA and matched BM, while comprehensive analysis identified important differentially methylated probes. Distinct differences in CNV alterations were observed in lung versus brain samples. The BM and EGFRM-PLA showed similar tumor purity and immune cell components. Overall, tumor methylation profiling provides clinically important information regarding biology of BM in EGFRM-PLA.

scholarly journals A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis

Cell Reports ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 3421-3434.e8 ◽  
Author(s):  
Jacob P. Hoj ◽  
Benjamin Mayro ◽  
Ann Marie Pendergast
Keyword(s):  
Brain Metastasis ◽  
Lung Adenocarcinoma ◽  
Feed Forward ◽  
Signaling Axis
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