scholarly journals DNA methylation accumulation in gastric mucosa adjacent to cancer after Helicobacter pylori eradication

2018 ◽  
Vol 144 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Sayumi Tahara ◽  
Tomomitsu Tahara ◽  
Noriyuki Horiguchi ◽  
Takema Kato ◽  
Yasuko Shinkai ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Helicobacter Pylori Eradication

Morphologic Characterization of Residual DNA Methylation in the Gastric Mucosa after Helicobacter Pylori Eradication

2017 ◽  
Vol 152 (5) ◽  
pp. S835
Author(s):  
Sayumi Tahara ◽  
Tomomitsu Tahara ◽  
Tetsuya Tsukamoto ◽  
Noriyuki Horiguchi ◽  
Tomohiko Kawamura ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Helicobacter Pylori Eradication

Su1179 Magnifying NBI Patterns of Gastric Mucosa After Helicobacter Pylori Eradication and its Potential Link to the Gastric Cancer Risk

2017 ◽  
Vol 85 (5) ◽  
pp. AB303
Author(s):  
Tomomitsu Tahara ◽  
Sayumi Tahara ◽  
Tetsuya Tsukamoto ◽  
Noriyuki Horiguchi ◽  
Tomohiko Kawamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Cancer Risk ◽  
Gastric Cancer Risk ◽  
Helicobacter Pylori Eradication ◽  
Potential Link

Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa

2001 ◽  
Vol 96 (6) ◽  
pp. 1758-1766 ◽  
Author(s):  
Brigitte Pignatelli ◽  
Brigitte Bancel ◽  
Martin Plummer ◽  
Shinya Toyokuni ◽  
Louis-Marc Patricot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Human Gastric Mucosa ◽  
Helicobacter Pylori Eradication

scholarly journals Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Satoshi Yamashita ◽  
Sohachi Nanjo ◽  
Emil Rehnberg ◽  
Naoko Iida ◽  
Hideyuki Takeshima ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Inflammation ◽  
Cpg Islands ◽  
Human Gastric Mucosa ◽  
Driver Genes ◽  
Age Related ◽  
A Genome ◽  
Aberrant Dna Methylation

Abstract Background Aberrant DNA methylation is induced by aging and chronic inflammation in normal tissues. The induction by inflammation is widely recognized as acceleration of age-related methylation. However, few studies addressed target genomic regions and the responsible factors in a genome-wide manner. Here, we analyzed methylation targets by aging and inflammation, taking advantage of the potent methylation induction in human gastric mucosa by Helicobacter pylori infection-triggered inflammation. Results DNA methylation microarray analysis of 482,421 CpG probes, grouped into 270,249 genomic blocks, revealed that high levels of methylation were induced in 44,461 (16.5%) genomic blocks by inflammation, even after correction of the influence of leukocyte infiltration. A total of 61.8% of the hypermethylation was acceleration of age-related methylation while 21.6% was specific to inflammation. Regions with H3K27me3 were frequently hypermethylated both by aging and inflammation. Basal methylation levels were essential for age-related hypermethylation while even regions with little basal methylation were hypermethylated by inflammation. When limited to promoter CpG islands, being a microRNA gene and high basal methylation levels strongly enhanced hypermethylation while H3K27me3 strongly enhanced inflammation-induced hypermethylation. Inflammation was capable of overriding active transcription. In young gastric mucosae, genes with high expression and frequent mutations in gastric cancers were more frequently methylated than in old ones. Conclusions Methylation by inflammation was not simple acceleration of age-related methylation. Targets of aberrant DNA methylation were different between young and old gastric mucosae, and driver genes were preferentially methylated in young gastric mucosa.

P53-positive cells in the gastric mucosa before and after Helicobacter pylori eradication

2000 ◽  
Vol 118 (4) ◽  
pp. A751
Author(s):  
Kiichi Satoh ◽  
Ken Kihira ◽  
Hiroshi Kawata ◽  
Keiko Fukazawa ◽  
Satoshi Kawakami ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Helicobacter Pylori Eradication ◽  
Before And After

scholarly journals Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA

Oncotarget ◽  
2016 ◽  
Vol 7 (24) ◽  
pp. 37132-37144 ◽  
Author(s):  
Yang Zhang ◽  
Xin-ran Zhang ◽  
Jong-lyul Park ◽  
Jong-hwan Kim ◽  
Lian Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Genome Wide ◽  
Blood Leukocyte
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