Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers

2017 ◽  
Vol 141 (12) ◽  
pp. 2537-2550 ◽  
Author(s):  
Hsin-Chun Feng ◽  
Jhuan-Yu Lin ◽  
Shu-Han Hsu ◽  
Wen-Yu Lan ◽  
Chang-Sheng Kuo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cell ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Metabolic Stress ◽  
Colorectal Cancers ◽  
Tumour Stage ◽  
Sonic Hedgehog Signaling ◽  
Invasive Tumour ◽  
Specific Malignancy

scholarly journals Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

Neuron ◽  
2011 ◽  
Vol 71 (2) ◽  
pp. 250-262 ◽  
Author(s):  
Rebecca A. Ihrie ◽  
Jugal K. Shah ◽  
Corey C. Harwell ◽  
Jacob H. Levine ◽  
Cristina D. Guinto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Adult Brain ◽  
Sonic Hedgehog Signaling ◽  
Positional Identity

scholarly journals Inhibition of Sonic hedgehog signaling impedes perivascular stem cell signaling and prevents neointimal lesion formation

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P602-P602
Author(s):  
J.- M. Daniel ◽  
J. Dutzmann ◽  
A. Koch ◽  
J. Bauersachs ◽  
D. Sedding
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Lesion Formation ◽  
Sonic Hedgehog Signaling
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