scholarly journals Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

Neuron ◽  
2011 ◽  
Vol 71 (2) ◽  
pp. 250-262 ◽  
Author(s):  
Rebecca A. Ihrie ◽  
Jugal K. Shah ◽  
Corey C. Harwell ◽  
Jacob H. Levine ◽  
Cristina D. Guinto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Adult Brain ◽  
Sonic Hedgehog Signaling ◽  
Positional Identity

scholarly journals A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Ellen C. Gingrich ◽  
Kendra Case ◽  
A. Denise R. Garcia
Keyword(s):  
Progenitor Cells ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Adult Brain ◽  
Substantial Contribution ◽  
Molecular Signaling ◽  
Sonic Hedgehog Signaling ◽  
Independent Manner ◽  
Shh Signaling ◽  
Cortical Astrocyte

Abstract Background The molecular signaling pathway, Sonic hedgehog (Shh), is critical for the proper development of the central nervous system. The requirement for Shh signaling in neuronal and oligodendrocyte development in the developing embryo are well established. However, Shh activity is found in discrete subpopulations of astrocytes in the postnatal and adult brain. Whether Shh signaling plays a role in astrocyte development is not well understood. Methods Here, we use a genetic inducible fate mapping approach to mark and follow a population of glial progenitor cells expressing the Shh target gene, Gli1, in the neonatal and postnatal brain. Results In the neonatal brain, Gli1-expressing cells are found in the dorsolateral corner of the subventricular zone (SVZ), a germinal zone harboring astrocyte progenitor cells. Our data show that these cells give rise to half of the cortical astrocyte population, demonstrating their substantial contribution to the cellular composition of the cortex. Further, these data suggest that the cortex harbors astrocytes from different lineages. Gli1 lineage astrocytes are distributed across all cortical layers, positioning them for broad influence over cortical circuits. Finally, we show that Shh activity recurs in mature astrocytes in a lineage-independent manner, suggesting cell-type dependent roles of the pathway in driving astrocyte development and function. Conclusion These data identify a novel role for Shh signaling in cortical astrocyte development and support a growing body of evidence pointing to astrocyte heterogeneity.

scholarly journals Inhibition of Sonic hedgehog signaling impedes perivascular stem cell signaling and prevents neointimal lesion formation

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P602-P602
Author(s):  
J.- M. Daniel ◽  
J. Dutzmann ◽  
A. Koch ◽  
J. Bauersachs ◽  
D. Sedding
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Lesion Formation ◽  
Sonic Hedgehog Signaling
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