scholarly journals The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation

2012 ◽  
Vol 131 (7) ◽  
pp. E1067-E1077 ◽  
Author(s):  
Maria Beatrice Morelli ◽  
Massimo Nabissi ◽  
Consuelo Amantini ◽  
Valerio Farfariello ◽  
Lucia Ricci-Vitiani ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Transient Receptor Potential Vanilloid ◽  
Transient Receptor

scholarly journals Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies

Brain ◽  
2010 ◽  
Vol 133 (6) ◽  
pp. 1798-1809 ◽  
Author(s):  
Magdalena Zimoń ◽  
Jonathan Baets ◽  
Michaela Auer-Grumbach ◽  
José Berciano ◽  
Antonio Garcia ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Transient Receptor Potential Vanilloid ◽  
Channel Gene ◽  
Transient Receptor

In silico research to assist the investigation of carboxamide derivatives as potent TRPV1 antagonists

2015 ◽  
Vol 11 (11) ◽  
pp. 2885-2899 ◽  
Author(s):  
Jinghui Wang ◽  
Yan Li ◽  
Yinfeng Yang ◽  
Jian Du ◽  
Shuwei Zhang ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Cancer Pain ◽  
In Silico ◽  
Essential Role ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Transient Receptor Potential Vanilloid ◽  
Transient Receptor

The transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel, is known for its essential role in the pathogenesis of various pain conditions such as nerve damage induced hyperalgesia, diabetic neuropathy and cancer pain.

Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia

2016 ◽  
Vol 21 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Takefumi Kamakura ◽  
Makoto Kondo ◽  
Yoshihisa Koyama ◽  
Yukiko Hanada ◽  
Yusuke Ishida ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Functional Expression ◽  
Ruthenium Red ◽  
Cation Channel ◽  
Trigeminal Ganglia ◽  
Transient Receptor Potential Vanilloid ◽  
Trpv Channels ◽  
Polymerase Chain ◽  
Transient Receptor

Transient receptor potential vanilloid (TRPV) 4 is a nonselective cation channel expressed in sensory neurons such as those in the dorsal root and trigeminal ganglia, kidney, and inner ear. TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-phorbol 12,13-didecanoate (4α-PDD). We investigated the expression of TRPV4 in rat vestibular ganglion (VG) neurons. The TRPV4 gene was successfully amplified from VG neuron mRNA using reverse-transcription polymerase chain reaction. Furthermore, immunoblotting showed positive expression of TRPV4 protein in VG neurons. Immunohistochemistry indicated that TRPV4 was localized predominantly on the plasma membrane of VG neurons. Calcium (Ca2+) imaging of VG neurons showed that 4α-PDD and/or hypotonic stimuli caused an increase in intracellular Ca2+ concentration ([Ca2+]i) that was almost completely inhibited by ruthenium red, a selective antagonist of TRPV channels. Interestingly, a [Ca2+]i increase was evoked by both hypotonic stimuli and 4α-PDD in approximately 38% of VG neurons. These data indicate that TRPV4 is functionally expressed in VG neurons as an ion channel and that TRPV4 likely participates in VG neurons for vestibular neurotransmission as an osmoreceptor and/or mechanoreceptor.

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