scholarly journals TP53 Mutational signature for aristolochic acid: an environmental carcinogen

2011 ◽  
Vol 129 (6) ◽  
pp. 1532-1536 ◽  
Author(s):  
Masaaki Moriya ◽  
Neda Slade ◽  
Branko Brdar ◽  
Zvonimir Medverec ◽  
Karla Tomic ◽  
...  
Keyword(s):  
Aristolochic Acid ◽  
Environmental Carcinogen ◽  
Mutational Signature

scholarly journals Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

2013 ◽  
Vol 5 (197) ◽  
pp. 197ra102-197ra102 ◽  
Author(s):  
M. L. Hoang ◽  
C.-H. Chen ◽  
V. S. Sidorenko ◽  
J. He ◽  
K. G. Dickman ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Aristolochic Acid ◽  
Acid Exposure ◽  
Mutational Signature ◽  
Whole Exome

1164 TP53 Mutational Signature of Aristolochic Acid in Carcinomas of the Upper Urinary Tract

2012 ◽  
Vol 48 ◽  
pp. S280
Author(s):  
N. Slade ◽  
M. Moriya ◽  
B. Brdar ◽  
B. Jelakovic ◽  
Z. Medverec ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Aristolochic Acid ◽  
Upper Urinary Tract ◽  
Mutational Signature

Mutational signature of aristolochic acid: Clue to the recognition of a global disease

DNA Repair ◽  
2016 ◽  
Vol 44 ◽  
pp. 205-211 ◽  
Author(s):  
Thomas A. Rosenquist ◽  
Arthur P. Grollman
Keyword(s):  
Aristolochic Acid ◽  
Mutational Signature

Mutational Processes in Hepatocellular Carcinoma: The Story of Aristolochic Acid

2019 ◽  
Vol 39 (03) ◽  
pp. 334-340 ◽  
Author(s):  
Jean-Charles Nault ◽  
Eric Letouzé
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Tumor Cells ◽  
Dna Adducts ◽  
Aristolochic Acid ◽  
Acid Form ◽  
Mutational Signatures ◽  
Mutational Signature ◽  
Hepatocellular Carcinomas ◽  
Mutational Processes

AbstractEach hepatocellular carcinoma displays dozens of mutations in driver and passenger genes. The analysis of the types of substitutions and their trinucleotide context defines mutational signatures that recapitulate the endogenous and exogenous mutational processes operative in tumor cells. Aristolochic acid is present in plants from the genus Aristolochia and causes chronic nephropathy. Moreover, aristolochic acid has genotoxic properties responsible for the occurrence of urothelial carcinoma. Metabolites of aristolochic acid form DNA adducts on adenine residues leading to a specific mutational signature with almost exclusively A:T to T:A transversions, preferentially in a CTG trinucleotide context. Interestingly, this mutational fingerprint has been identified in a subset of hepatocellular carcinomas suggesting that aristolochic acid is a new risk factor for hepatocellular carcinoma. More data are warranted to capture the real impact of exposure to aristolochic acid in hepatocellular carcinoma occurrence worldwide.

scholarly journals Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid

2014 ◽  
Vol 136 (12) ◽  
pp. 2967-2972 ◽  
Author(s):  
Bojan Jelaković ◽  
Xavier Castells ◽  
Karla Tomić ◽  
Maude Ardin ◽  
Sandra Karanović ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Cell ◽  
Aristolochic Acid ◽  
Renal Cell Carcinomas ◽  
Mutational Signature

scholarly journals Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma

Theranostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 4323-4333 ◽  
Author(s):  
Huan Lu ◽  
Yuan Liang ◽  
Bao Guan ◽  
Yue Shi ◽  
Yanqing Gong ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Aristolochic Acid ◽  
Low Risk ◽  
Upper Tract Urothelial Carcinoma ◽  
Upper Tract ◽  
Mutational Signature
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