scholarly journals Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid

2014 ◽  
Vol 136 (12) ◽  
pp. 2967-2972 ◽  
Author(s):  
Bojan Jelaković ◽  
Xavier Castells ◽  
Karla Tomić ◽  
Maude Ardin ◽  
Sandra Karanović ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Cell ◽  
Aristolochic Acid ◽  
Renal Cell Carcinomas ◽  
Mutational Signature

scholarly journals Geographic Variation of Chronic Kidney Disease Prevalence: Correlation with the Incidence of Renal Cell Carcinoma or Urothelial Carcinoma?

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Yit-Sheung Yap ◽  
Kai-Wen Chuang ◽  
Chun-Ju Chiang ◽  
Hung-Yi Chuang ◽  
Sheng-Nan Lu
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Late Stage ◽  
Renal Cell ◽  
Risk Groups ◽  
Incidence Rates ◽  
Geographic Variations

Background. The aim of this study is to evaluate whether geographic variations in the prevalence of late-stage chronic kidney disease (CKD) exist and are associated with incidence rates of renal cell carcinoma (RCC), upper tract urothelial carcinoma (UTUC), or lower tract urothelial carcinoma (LTUC).Methods. Prevalence rates of late-stage CKD for 366 townships (n>30) in Taiwan were calculated for 1,518,241 and 1,645,151 subjects aged 40 years or older in years 2010 and 2009, respectively. Late-stage CKD prevalence in year 2010 was used as a training set and its age-adjusted standardized morbidity rates (ASMR) were divided into three groups as defined <1.76%, 1.76% ≤ ASMR < 2.64%, and ≥2.64%, respectively. Year 2009, defined as the validation set, was used to validate the results.Results. The ASMR of late-stage CKD in years 2010 and 2009 were 1.76%, and 2.09%, respectively. Geographic variations were observed, with notably higher rates of disease in areas of the central, southwestern mountainside, and southeastern seaboard. There were no significant differences among different combined risk groups of RCC, UTUC, and LTUC incidence.Conclusion. The substantial geographic variations in the prevalence of late-stage CKD exist, but are not correlated with RCC, UTUC, or LTUC incidence.

Baseline chronic kidney disease is associated with toxicity and survival in patients treated with targeted therapies for metastatic renal cell carcinoma

2015 ◽  
Vol 26 (8) ◽  
pp. 866-871 ◽  
Author(s):  
François-Xavier Nouhaud ◽  
Christian Pfister ◽  
Guillaume Defortescu ◽  
Anthony Giwerc ◽  
David Charbit ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Targeted Therapies ◽  
Renal Cell

scholarly journals Increased risks of chronic kidney disease associated with prescribed Chinese herbal products suspected to contain aristolochic acid

Nephrology ◽  
2009 ◽  
Vol 14 (2) ◽  
pp. 227-234 ◽  
Author(s):  
MING-NAN LAI ◽  
JUNG-NIEN LAI ◽  
PAU-CHUNG CHEN ◽  
WEI-LUM TSENG ◽  
YA-YIN CHEN ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aristolochic Acid ◽  
Herbal Products ◽  
Chinese Herbal
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