A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

2012 ◽  
Vol 56 (4) ◽  
pp. 370-374 ◽  
Author(s):  
Setsu Akamatsu ◽  
Shoji Kodama ◽  
Yukari Himeji ◽  
Naomi Ikuta ◽  
Nikako Shimagaki
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Conventional Cytology ◽  
Liquid Based Cytology

scholarly journals A comparison of liquid-based and conventional cytology using data for cervical cancer screening from the Japan Cancer Society

2019 ◽  
Vol 50 (2) ◽  
pp. 138-144
Author(s):  
Kiyoshi Ito ◽  
Ryusei Kimura ◽  
Hiroshi Konishi ◽  
Nobuyoshi Ozawa ◽  
Nobuo Yaegashi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cancer Society ◽  
Detection Rates ◽  
Predictive Values ◽  
Conventional Cytology ◽  
Significant Difference ◽  
Liquid Based Cytology ◽  
Using Data

Abstract Objective Liquid-based cytology has replaced conventional cytology in cervical cancer screening in many countries. However, a detailed comparison of liquid-based cytology with conventional cytology has not been reported in Japan. Therefore, the aim of the study is to evaluate efficacy of liquid-based cytology in Japan. Methods We first evaluated the prevalence of use of liquid-based cytology and then examined the efficacy of liquid-based cytology and conventional cytology for detecting CIN and the rate of unsatisfactory specimens using data from cancer screening collected by the Japanese Cancer Society from FY2011 to FY2014. A Poisson regression model with random effects analyses was used to classify histological outcomes and unsatisfactory specimens using liquid-based cytology compared to conventional cytology. Results A total of 3 815 131 women were analyzed in the study. The rate of liquid-based cytology increased from approximately 8% in FY2011 to 37% in FY2014. Compared to conventional cytology, the detection rates with liquid-based cytology were significantly higher (1.42 times) for CIN1+ [detection rate ratio (DRR) = 1.42, 95% confidence interval (CI) 1.35–1.48, P < 0.001] and CIN2+ (DRR = 1.16, 95% CI 1.08–1.25, P < 0.001). Positive predictive value ratios of CIN1+ and CIN2+ were also significantly higher for liquid-based cytology than for conventional cytology. However, there was no significant difference between liquid-based cytology and conventional cytology for detection rates and positive predictive values of CIN3+ and cancer. The rate of unsatisfactory specimens was significantly lower with liquid-based cytology compared to conventional cytology (DRR = 0.07, 95% CI 0.05–0.09, P < 0.001). Conclusions In order to avoid the unsatisfactory specimens in cervical cancer screening, the results of this study did indicate that liquid-based cytology was more useful than conventional cytology in practical standpoints.

scholarly journals Comparative evaluation of conventional cytology and a low-cost liquid-based cytology technique, EziPREP™, for cervicovaginal smear reporting: A split sample study

CytoJournal ◽  
2019 ◽  
Vol 16 ◽  
pp. 22
Author(s):  
Ruchika Gupta ◽  
Ravi Yadav ◽  
Akhileshwar Sharda ◽  
Dinesh Kumar ◽  
Sandeep ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Low Cost ◽  
Low Grade ◽  
Cervical Lesions ◽  
Widespread Application ◽  
Conventional Cytology ◽  
Split Sample ◽  
Liquid Based Cytology

Background: Liquid-based cytology (LBC) for cervical cancer screening offers several advantages over conventional cytology. However, the extremely high cost of the current approved devices precludes widespread application of LBC technique in resource-constrained countries. This study aimed to evaluate the performance of an indigenous low-cost LBC technique, EziPREP™ (EP), against conventional preparations (CPs) for cervical cancer screening. Materials and Methods: A cross-sectional split-sample study with consecutive cervical sampling was conducted on 515 women attending the clinic at our institute. CP smears were prepared as per the standard technique using spatula and endocervical brush followed by detaching the head of brush into the fixative vial of EP. The EP samples were processed as per the manufacturer's protocol. Both CP and EP smears were stained using standard Papanicolaou stain protocol. Both sets of smears were evaluated for staining quality, morphologic details, and cytologic diagnoses. Cytologic diagnoses were correlated with cervical biopsy findings, wherever available. Performance characteristics of the two techniques were calculated. Results: The unsatisfactory rate for CP was 1.0%, while on EP, 1.3% smears had inadequate cellular material. The staining quality and morphological details were comparable in both sets of smears. The detection of infections and epithelial cell abnormality was more, though not statistically significant in EP smears. There was a 98% concordance in cytologic diagnosis between CP and EP smears. Cytohistologic concordance was observed in 96% of cases for both CP and EP smears. Although the time taken for processing and staining of smears was higher for EP (2.5 min for EP per smear and 1.6 min for CP per smear), the screening time reduced from 6.5 min per smear for CP to 2.2 min in EP smears. Conclusion: EP provides monolayered cervical smears with vivid morphological details, leading to reduced screening time and relatively higher pick-up of infections and low-grade cervical lesions as compared to conventional smears. The availability of such low-cost devices may enable wider application of cytology-based cervical cancer screening in low-resource countries.

ConventionalPap smearand liquid based cytology for cervical cancer screening - a comparative study

2007 ◽  
Vol 24 (4) ◽  
pp. 167 ◽  
Author(s):  
RK Sherwani ◽  
T Khan ◽  
K Akhtar ◽  
A Zeba ◽  
FA Siddiqui ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Comparative Study ◽  
Cervical Cancer Screening ◽  
Liquid Based Cytology

scholarly journals Conventional pap’s test and liquid-based cytology for the screening of cervical cancer with back up colposcopy directed biopsy

2019 ◽  
Vol 12 (2) ◽  
pp. 105-108
Author(s):  
Sabera Khatun ◽  
Sayada Fatema Khatun
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Cervical Cancer Screening ◽  
False Negative ◽  
Precancerous Lesion ◽  
True Negative ◽  
Liquid Based Cytology

The aim of this study was to screen the suspected cervical cancer patients (n=100) by liquid-based cytology and conventional pap’s smear followed by colposcopic biopsy from July 2016 to June 2017. In conventional pap’s test, 73 cases were true negative whereas 25 cases were false negative. However, in liquid-based cytology, 68 cases were true negative and 23 cases were false negative. Finally when colposcopic examinations were done, 61 cases were true negative and 15 cases were false negative. The sensitivity of liquid-based cytology was 11.5% for cervical cancer screening which was more than the conventional pap’s smear (3.8%). In conclusion, liquid-based cytology should be more preferable method than the than conventional pap’s smear for the diagnosis of precancerous lesion of the cervix.

Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan

2010 ◽  
Vol 111 (2) ◽  
pp. 110-114 ◽  
Author(s):  
Masaki Inoue ◽  
Makoto Okamura ◽  
Shigeru Hashimoto ◽  
Masahiro Tango ◽  
Toshihiko Ukita
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Hpv Testing ◽  
Conventional Cytology
Sign in / Sign up

Export Citation Format

Share Document