P18is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development

2009 ◽  
Vol 124 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Wendy van Veelen ◽  
Rob Klompmaker ◽  
Martijn Gloerich ◽  
Carola J.R. van Gasteren ◽  
Eric Kalkhoven ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Medullary Thyroid Carcinoma ◽  
Suppressor Gene ◽  
Medullary Thyroid

scholarly journals Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma

Oncogene ◽  
2011 ◽  
Vol 31 (35) ◽  
pp. 3961-3972 ◽  
Author(s):  
A Macià ◽  
P Gallel ◽  
M Vaquero ◽  
M Gou-Fabregas ◽  
M Santacana ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Medullary Thyroid Carcinoma ◽  
Suppressor Gene ◽  
Medullary Thyroid ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

Abstract 2181: Tumor suppressor role of Notch3 in medullary thyroid carcinoma

2011 ◽  
Author(s):  
Renata Jaskula-Sztul ◽  
Jacob Eide ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid

A frequent mutation/polymorphism in tumor suppressor gene INK4B (MTS-2) in papillary and medullary thyroid cancer

Surgery ◽  
1996 ◽  
Vol 120 (6) ◽  
pp. 1081-1088 ◽  
Author(s):  
Peter E. Goretzki ◽  
V. Gorelov ◽  
Cornelia Dotzenrath ◽  
J. Witte ◽  
H.D. Roeher
Keyword(s):  
Thyroid Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Medullary Thyroid Cancer ◽  
Suppressor Gene ◽  
Frequent Mutation ◽  
Medullary Thyroid

scholarly journals No mutations but an increased frequency of SDHx polymorphisms in patients with sporadic and familial medullary thyroid carcinoma

2005 ◽  
Vol 12 (4) ◽  
pp. 1011-1016 ◽  
Author(s):  
M Montani ◽  
A M Schmitt ◽  
S Schmid ◽  
T Locher ◽  
P Saremaslani ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Tumor Suppressor Genes ◽  
Germline Mutations ◽  
Functional Connection ◽  
Suppressor Genes ◽  
Medullary Thyroid ◽  
Chromosome 1P ◽  
Familial Pheochromocytoma

Germline mutations of the three succinate dehydrogenase subunits SDHB, SDHC and SDHD have recently been associated with familial pheochromocytoma and paraganglioma. Several reasons make these genes candidate tumor suppressor genes for medullary thyroid carcinoma (MTC): (1) SDHB lies on chromosome 1p, the region known to be deleted most frequently in MTC, (2) MTCs develop from neural crest-derived cells, as do pheochromocytomas and paragangliomas and (3) patients with germline mutations of the Ret-protooncogene develop MTCs as well as pheochromocytomas, indicating a relationship of these tumors on a genetic level. Therefore, we attempted to determine whether the tumor suppressor genes SDHB, SDHC and SDHD are involved in sporadic and familial MTC. Somatic mutations of the SDH subunits were absent in all 35 investigated MTCs. Loss of heterozygosity was found in 27% (SDHB) and 4% (SDHD) respectively. While the frequency of non-coding, intronic polymorphisms did not differ in MTC patients compared with a control population, an accumulation of amino-acid coding polymorphisms (S163P in SDHB as well as G12S and H50R in SDHD) was found among MTC patients especially patients with familial tumors, suggesting a functional connection of coding SDH polymorphisms to activating Ret mutations.

scholarly journals Evidences that the polymorphism Pro-282-Ala within the tumor suppressor gene WWOX is a new risk factor for differentiated thyroid carcinoma

2011 ◽  
Vol 129 (12) ◽  
pp. 2816-2824 ◽  
Author(s):  
Lisa Cancemi ◽  
Cristina Romei ◽  
Sara Bertocchi ◽  
Giulia Tarrini ◽  
Irene Spitaleri ◽  
...  
Keyword(s):  
Risk Factor ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Differentiated Thyroid Carcinoma

scholarly journals Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma

Oncotarget ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 5830-5841 ◽  
Author(s):  
De-Tao Yin ◽  
Jianhui Xu ◽  
Mengyuan Lei ◽  
Hongqiang Li ◽  
Yongfei Wang ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
The Novel ◽  
Papillary Thyroid

Tumor Suppressor Gene Allelic Loss Profiles of the Variants of Papillary Thyroid Carcinoma

2004 ◽  
Vol 13 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Jennifer L. Hunt ◽  
Melissa Fowler ◽  
Deren Lomago ◽  
Laura Niehouse ◽  
Eizaburo Sasatomi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Allelic Loss ◽  
Papillary Thyroid

Abstract 501: A RET-related microRNA, miR-153-3p, acts as a tumor suppressor in medullary thyroid carcinoma (MTC) via S6K signaling

2018 ◽  
Author(s):  
Lauren Jin Suk Joo ◽  
Jocelyn Weiss ◽  
Anthony J. Gill ◽  
Roderick Clifton-Bligh ◽  
Himanshu Brahmbhatt ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Medullary Thyroid
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