scholarly journals Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma

Oncotarget ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 5830-5841 ◽  
Author(s):  
De-Tao Yin ◽  
Jianhui Xu ◽  
Mengyuan Lei ◽  
Hongqiang Li ◽  
Yongfei Wang ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
The Novel ◽  
Papillary Thyroid

Tumor Suppressor Gene Allelic Loss Profiles of the Variants of Papillary Thyroid Carcinoma

2004 ◽  
Vol 13 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Jennifer L. Hunt ◽  
Melissa Fowler ◽  
Deren Lomago ◽  
Laura Niehouse ◽  
Eizaburo Sasatomi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Allelic Loss ◽  
Papillary Thyroid

Clinicopathological Roles of Alterations of Tumor Suppressor Gene p16 in Papillary Thyroid Carcinoma

2006 ◽  
Vol 14 (5) ◽  
pp. 1772-1779 ◽  
Author(s):  
Alfred King Yin Lam ◽  
Chung Yau Lo ◽  
Pauline Leung ◽  
Brian Hung Hin Lang ◽  
Wai Fun Chan ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Papillary Thyroid

scholarly journals NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene

2020 ◽  
Vol 18 (4) ◽  
Author(s):  
Sara Sheikholeslami ◽  
Fereidoun Azizi ◽  
Asghar Ghasemi ◽  
Abbas Alibakhshi ◽  
Hossein Parsa ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Mrna Level ◽  
Methylation Status ◽  
Nodular Goiter ◽  
Suppressor Gene ◽  
Start Codon ◽  
Papillary Thyroid

Background: Thyroid cancer is the fourth most common cancer in the world. Papillary thyroid carcinoma (PTC) accounts for 80% of all types of thyroid neoplasm. Epigenetic alterations such as DNA methylation are known as the main cause of different types of cancers through inactivation of tumor suppressor genes. Objectives: In the present study, the expression and methylation of suggested gene namely nucleolar protein 4 (NOL4) in PTC in comparison to multi nodular goiter (MNG) have been studied. Methods: Forty-one patients with PTC and 38 patients affected by MNG were recruited. Thyroid tissues were obtained during thyroidectomy. RNA and DNA were extracted from thyroid tissues. Quantitative RT-PCR assay was performed for determining the mRNA level of NOL4 while methylation-sensitive high resolution methylation was applied for assessing the methylation status with designing six pairs primers for six regions on gene promoter which were named from NOL4 (a) to NOL4 (f). Results: Methylation assessment of 81 CpG islands in the promoter region of NOL4 gene revealed that NOL4 (f), the nearest region to the start codon, was significantly hypermethylated in PTC cases compared to MNG cases. NOL4 level in PTC cases in comparison with MNG cases were downregulated. The methylation status and mRNA level of NOL4 (f) were associated with age of diagnosis (Age of the patient at the time of diagnosis), lymph node metastasis, and advanced stages of disease. Conclusions: These data suggested an aberrant promoter hyper-methylation of NOL4 in PTC cases may be linked with its downregulation. Therefore, NOL4 gene can be proposed as a potential tumor suppressor gene in PTC tissues.

scholarly journals A novel tumor suppressor gene NCOA5 is correlated with progression in papillary thyroid carcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 307-311 ◽  
Author(s):  
Zhou-Ci Zheng ◽  
Qing-Xuan Wang ◽  
Wei Zhang ◽  
Xiao-Hua Zhang ◽  
Du-Ping Huang
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Tumor Suppressor ◽  
Thyroid Carcinoma ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Papillary Thyroid

scholarly journals Biochemical and molecular characterization of the novel BRAFV599Ins mutation detected in a classic papillary thyroid carcinoma

Oncogene ◽  
2006 ◽  
Vol 25 (30) ◽  
pp. 4235-4240 ◽  
Author(s):  
S Moretti ◽  
A Macchiarulo ◽  
V De Falco ◽  
N Avenia ◽  
F Barbi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Molecular Characterization ◽  
The Novel ◽  
Papillary Thyroid

scholarly journals Functional Characterization of the Novel T599I-VKSRdel BRAF Mutation in a Follicular Variant Papillary Thyroid Carcinoma

2008 ◽  
Vol 93 (11) ◽  
pp. 4398-4402 ◽  
Author(s):  
Valentina De Falco ◽  
Riccardo Giannini ◽  
Anna Tamburrino ◽  
Clara Ugolini ◽  
Cristiana Lupi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Functional Characterization ◽  
The Novel ◽  
Papillary Thyroid ◽  
Follicular Variant

Cytogenetic characterization of a new human papillary thyroid carcinoma permanent cell line (GLAG-66)

1993 ◽  
Vol 67 (2) ◽  
pp. 117-122 ◽  
Author(s):  
P. Antonini ◽  
G. Linares ◽  
N. Gaillard ◽  
A.M. Venuat ◽  
M. Schlumberger ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Line ◽  
Papillary Thyroid ◽  
Permanent Cell Line ◽  
Permanent Cell ◽  
Cytogenetic Characterization
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