α-Galactosylceramide-loaded, antigen-expressing B cells prime a wide spectrum of antitumor immunity

2008 ◽  
Vol 122 (12) ◽  
pp. 2774-2783 ◽  
Author(s):  
Yeon-Jeong Kim ◽  
Hyun-Jeong Ko ◽  
Yun-Sun Kim ◽  
Dong-Hyeon Kim ◽  
Seock Kang ◽  
...  
Keyword(s):  
B Cells ◽  
Antitumor Immunity ◽  
Wide Spectrum

Abstract 941: B cells are required to generate optimal antitumor immunity in response to PD-1 blockade treatment

2019 ◽  
Author(s):  
Shubhra Singh ◽  
Karishma Bavisi ◽  
Jason Roszik ◽  
Adi Diab ◽  
Richard E. Davis ◽  
...  
Keyword(s):  
B Cells ◽  
Antitumor Immunity

scholarly journals Capacity of Epstein–Barr virus to infect monocytes and inhibit their development into dendritic cells is affected by the cell type supporting virus replication

2004 ◽  
Vol 85 (10) ◽  
pp. 2767-2778 ◽  
Author(s):  
Andre Ortlieb Guerreiro-Cacais ◽  
LiQi Li ◽  
Daria Donati ◽  
Maria Teresa Bejarano ◽  
Andrew Morgan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Cells ◽  
Epithelial Cells ◽  
Virus Replication ◽  
Epstein Barr Virus ◽  
Wide Spectrum ◽  
Human Herpesvirus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Induced Apoptosis

Epstein–Barr virus (EBV) is a ubiquitous human herpesvirus that is involved in the pathogenesis of a wide spectrum of malignant and non-malignant diseases. Strong evidence implicates T lymphocytes in the control of EBV replication and tumorigenesis, but cellular components of the innate immune system are poorly characterized in terms of their function in the development of EBV-specific immunity or interaction with the virus. This study demonstrates that EBV virions produced in epithelial cells surpass their B cell-derived counterparts in the capacity to enter monocytes and inhibit their development into dendritic cells (DCs). Different ratios of the gp42 and gH glycoproteins in the envelope of virions that were derived from major histocompatibility complex class II-positive or -negative cells accounted primarily for the differences in EBV tropism. EBV is shown to enter both monocytes and DCs, although the cells are susceptible to virus-induced apoptosis only if infected at early stages of DC differentiation. The purified gH/gL heterodimer binds efficiently to monocytes and DCs, but not to B cells, suggesting that high expression levels of a putative binding partner for gH contribute to virus entry. This entry takes place despite very low or undetectable expression of CD21, the canonical EBV receptor. These results indicate that the site of virus replication, either in B cells or epithelial cells, alters EBV tropism for monocytes and DCs. This results in a change in the virus's immunomodulating capacity and may have important implications for the regulation of virus–host interactions during primary and chronic EBV infection.

scholarly journals CD1d-Restricted T Cells License B Cells to Generate Long-Lasting Cytotoxic Antitumor Immunity In vivo

2006 ◽  
Vol 66 (13) ◽  
pp. 6843-6850 ◽  
Author(s):  
Yeonseok Chung ◽  
Byung-Seok Kim ◽  
Yeon-Jeong Kim ◽  
Hyun-Jeong Ko ◽  
Sung-Youl Ko ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Antitumor Immunity

scholarly journals Regular Exercise May Restore Certain Age-Related Alterations of Adaptive Immunity and Rebalance Immune Regulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Gábor Papp ◽  
Krisztina Szabó ◽  
Ilona Jámbor ◽  
Marianna Mile ◽  
Alexandra Réka Berki ◽  
...  
Keyword(s):  
B Cells ◽  
Immune Regulation ◽  
Wide Spectrum ◽  
Exercise Program ◽  
Treg Cells ◽  
Memory B Cells ◽  
Effector Memory ◽  
Regular Exercise ◽  
Healthy Elderly ◽  
Age Related

Age-related changes of the immune system lead to an increased morbidity and mortality due to enhanced vulnerability to infectious diseases and malignancies. Recent studies revealed the important effects of physical activity on immune functions, which may largely depend on the type of exercise, its intensity and duration. However, limited information is available regarding the immunological effects of sport activities in older ages. The aim of our study was to examine the changes in a wide spectrum of lymphocyte subtypes after regular workout among healthy elderly individuals. We enrolled 29 elderly women with sedentary lifestyle (mean age: 67.03 ± 3.74 years) to take part in a 6-week long functional conditioning gymnastic exercise program. The percentages of peripheral natural killer (NK), NKT cells, T and B lymphocyte subtypes (early-/late-activated T, naïve and memory T, cytotoxic T (Tc), T-helper (Th)1, Th2, Th17, T regulatory type 1 (Tr1), CD4+CD127lo/-CD25bright Treg, as well as naïve and memory B cells) were determined by flow cytometry. Evaluation of the changes in functional capability of Treg cells was based on in vitro functional assays. At the end of exercise program, in parallel with improvements in body composition and physical performance, significant changes in naïve and memory lymphocyte ratios were observed. Importantly, levels of naïve Tc cells elevated, ratios of effector memory Tc cells decreased and distribution of memory B cells rearranged as well. Additionally, proportions of late-activated HLA-DR+ T cells increased, while percentages of anti-inflammatory interleukin (IL)-10 producing Tr1 cells, as well as immunosuppressive CD4+CD127lo/-CD25bright Treg cells decreased following the exercise workout. Changes observed after the regular exercise program indicate an improvement in the age-related redistribution of certain naïve and memory cell proportions and a retuned immune regulation in older ages.

Abstract 941: B cells are required to generate optimal antitumor immunity in response to PD-1 blockade treatment

2019 ◽  
Author(s):  
Shubhra Singh ◽  
Karishma Bavisi ◽  
Jason Roszik ◽  
Adi Diab ◽  
Richard E. Davis ◽  
...  
Keyword(s):  
B Cells ◽  
Antitumor Immunity

scholarly journals Wogonin Suppresses IL-10 Production in B Cells via STAT3 and ERK Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Li Fan ◽  
Dongbo Qiu ◽  
Guo Huang ◽  
Jingrou Chen ◽  
Qiongli Wu ◽  
...  
Keyword(s):  
B Cells ◽  
Signaling Pathway ◽  
Wide Spectrum ◽  
Potential Effect ◽  
Protective Role ◽  
Erk Signaling ◽  
Protein Levels ◽  
Cell Functions

Wogonin (5,7-dihydroxy-8-methoxyflavone) is an ingredient of the extracts from Scutellaria baicalensis, which has documented a wide spectrum of anti-inflammatory and antitumor activities, including inhibiting regulatory T cells, regulating effector T cell functions, and mediating macrophage immunity. However, the potential effect of Wogonin on B cells has not been fully understood. Here, our results showed that Wogonin inhibited IL-10 secretion in B cells. When purified B cells were activated by lipopolysaccharide (LPS) in vitro, the amount of IL-10 production in supernatant was decreased by Wogonin significantly. The protective role of B cells on dextran sulfate sodium- (DSS-) induced colitis was alleviated after exposure to Wogonin. Furthermore, administration of Wogonin on LPS-treated B cells suppressed phosphorylation of STAT3 and ERK, but not AKT. Interestingly, among those IL-10 signaling-associated transcription factors, mRNA and protein levels of Hif-1α were specifically decreased by Wogonin. Overall, our study indicates that Wogonin suppresses potentially IL-10 production in B cells via inhibition of the STAT3 and ERK signaling pathway as well as inhibition of mRNA and protein levels of the transcription factor Hif-1α. These results provide novel and potential molecular targets of Wogonin in B cells and help us further understand its mechanism of action, which could potentially improve its clinical application in the future.

Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6581-6588 ◽  
Author(s):  
Xin Wei ◽  
Yangqiu Jin ◽  
Yinpu Tian ◽  
Huiyuan Zhang ◽  
Jie Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
B Cells ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Regulatory B Cells
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