scholarly journals Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase

2006 ◽  
Vol 119 (7) ◽  
pp. 1567-1576 ◽  
Author(s):  
H.M. Li ◽  
C. Man ◽  
Y. Jin ◽  
W. Deng ◽  
Y.L. Yip ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cytogenetic Changes ◽  
Nasopharyngeal Epithelial

scholarly journals Epstein–Barr Virus Infection of Pseudostratified Nasopharyngeal Epithelium Disrupts Epithelial Integrity

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2722
Author(s):  
Fenggang Yu ◽  
Yanan Lu ◽  
Yingying Li ◽  
Yuji Uchio ◽  
Utomo Andi Pangnguriseng ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Epstein Barr Virus ◽  
Basal Layer ◽  
Infection Model ◽  
Hybridization Technique ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Nasopharyngeal Epithelial

Epstein–Barr virus (EBV) is a human oncogenic virus that causes several types of tumor, such as Burkitt’s lymphoma and nasopharyngeal carcinoma (NPC). NPC tumor cells are clonal expansions of latently EBV-infected epithelial cells. However, the mechanisms by which EBV transforms the nasopharyngeal epithelium is hampered, because of the lack of good in vitro model to pursue oncogenic process. Our primary nasopharyngeal epithelial cell cultures developed pseudostratified epithelium at the air-liquid interface, which was susceptible to EBV infection. Using the highly sensitive RNA in situ hybridization technique, we detected viral infection in diverse cell types, including ciliated cells, goblet cells, and basal cells. EBV-encoded small RNA-positive cells were more frequently detected in the suprabasal layer than in the basal layer. We established the most physiologically relevant EBV infection model of nasopharyngeal epithelial cells. This model will advance our understanding of EBV pathogenesis in the development of NPC.

Expression of Epstein-Barr virus-encoded LMP1 and hTERT extends the life span and immortalizes primary cultures of nasopharyngeal epithelial cells

2010 ◽  
Vol 82 (10) ◽  
pp. 1711-1723 ◽  
Author(s):  
Yim-Ling Yip ◽  
Chi-Man Tsang ◽  
Wen Deng ◽  
Pak-Yan Cheung ◽  
Yuesheng Jin ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Life Span ◽  
Epstein Barr Virus ◽  
Primary Cultures ◽  
Barr Virus ◽  
Epstein Barr ◽  
Nasopharyngeal Epithelial

scholarly journals Bmi-1 Is a Novel Molecular Marker of Nasopharyngeal Carcinoma Progression and Immortalizes Primary Human Nasopharyngeal Epithelial Cells

2006 ◽  
Vol 66 (12) ◽  
pp. 6225-6232 ◽  
Author(s):  
Li-Bing Song ◽  
Mu-Sheng Zeng ◽  
Wen-Ting Liao ◽  
Ling Zhang ◽  
Hao-Yuan Mo ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cells ◽  
Molecular Marker ◽  
Nasopharyngeal Epithelial

Abstract 1300: The potential role of NF-κB activation in the immortalization of nasopharyngeal epithelial cells.

2013 ◽  
Author(s):  
Dandan Zhu ◽  
Yim Ling Yip ◽  
Wen Deng ◽  
Chi Man Tsang ◽  
Lai Man Cheung ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Potential Role ◽  
Nasopharyngeal Epithelial
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