scholarly journals Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer

2005 ◽  
Vol 118 (8) ◽  
pp. 2013-2019 ◽  
Author(s):  
Gro Wiedswang ◽  
Elin Borgen ◽  
Cecilie Schirmer ◽  
Rolf Kåresen ◽  
Gunnar Kvalheim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Tumor Cells ◽  
Clinical Significance ◽  
Occult Tumor ◽  
Occult Tumor Cells

Increased Risk of Systemic Relapses Associated With Bone Marrow Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor

2003 ◽  
Vol 21 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Gudrun Schleiermacher ◽  
Martine Peter ◽  
Odile Oberlin ◽  
Thierry Philip ◽  
Hervé Rubie ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Rt Pcr ◽  
Occult Tumor ◽  
Relapse Pattern ◽  
Localized Disease ◽  
Occult Tumor Cells ◽  
Pcr Targeting ◽  
Ewing Tumor

Purpose: The presence of metastasis is a major prognostic factor in Ewing tumor (ET). The relapse pattern of patients with localized tumors has long indicated that cases with disseminated ET cells escape detection at diagnosis. ET cells are characterized by specific gene fusions that can be detected with high sensitivity and specificity by reverse transcriptase polymerase chain reaction (RT-PCR). Patients and Methods: RT-PCR targeting EWS-FLI-1 or EWS-ERG transcripts was used to search for occult tumor cells in peripheral blood (PB) and bone marrow (BM) at diagnosis in 172 patients with ET, and the prognostic significance of this parameter was assessed. Results: As we suggested previously in a smaller series of patients, RT-PCR positivity of the BM was correlated with a high risk of adverse outcome in the overall study population (P = .007). More interestingly, among patients with otherwise localized tumors, BM micrometastasis also predicted significantly poorer disease-free survival rates (P = .043). The presence of circulating tumor cells (CTC) was more frequently observed in patients with large tumors (P = .006). CTC were associated with a poor outcome among patients with clinically localized disease (P = .045). Patients with clinically localized disease and peripheral occult tumor cells as evidenced by BM and/or PB RT-PCR positivity had axial or proximal tumors and experienced relapses at a systemic rather than at a local level. Conclusion: Patients with localized ET and BM micrometastasis or CTC are comparable to patients with metastases in terms of the localization of the primary tumor, outcome, and relapse pattern.

Immunocytochemical Detection of Occult Tumor Cells in the Bone Marrow: Prognostic Impact on Early Stages of Lung Cancer

2008 ◽  
Vol 41 (3) ◽  
pp. 267-271 ◽  
Author(s):  
M. Nosotti ◽  
D. Tosi ◽  
A. Palleschi ◽  
L. Rosso ◽  
P. Mendogni ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Marrow ◽  
Tumor Cells ◽  
Prognostic Impact ◽  
Occult Tumor ◽  
Early Stages ◽  
Immunocytochemical Detection ◽  
Occult Tumor Cells

Disseminated tumor cells in bone marrow of breast cancer patients–Comparison of immunocytochemistry and RT-PCR

2006 ◽  
Vol 66 (S 01) ◽  
Author(s):  
T Fehm ◽  
S Becker ◽  
MJ Banys ◽  
G Becker-Pergola ◽  
S Duerr-Stoerzer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Disseminated Tumor Cells ◽  
Breast Cancer Patients ◽  
Rt Pcr
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