scholarly journals Red meat consumption and risk of cancers of the proximal colon, distal colon and rectum: The Swedish Mammography Cohort

2004 ◽  
Vol 113 (5) ◽  
pp. 829-834 ◽  
Author(s):  
Susanna C. Larsson ◽  
Joseph Rafter ◽  
Lars Holmberg ◽  
Leif Bergkvist ◽  
Alicja Wolk
Keyword(s):  
Meat Consumption ◽  
Distal Colon ◽  
Proximal Colon ◽  
Red Meat ◽  
Colon And Rectum

scholarly journals Diurnal variations in the concentrations of volatile fatty acids in the alimentary tracts of wild rabbits

1972 ◽  
Vol 27 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Susan J. Henning ◽  
F. J. R. Hird
Keyword(s):  
Fatty Acids ◽  
Volatile Fatty Acids ◽  
Distal Colon ◽  
Proximal Colon ◽  
Diurnal Variations ◽  
Gut Contents ◽  
Excretion Pattern ◽  
Colon And Rectum ◽  
High Concentrations

1. Wild rabbits were caught during both phases of the excretory cycle and their gut contents were analysed for volatile fatty acids (VFA).2. All rabbits were found to have high concentrations of VFA in the caecum and in the proximal colon. Acetic was the most abundant acid followed by n-butyric, then propionic.3. VFA concentrations in the caecum and in the proximal colon of rabbits caught during the day and during the night were similar. Hard pellets from the distal colon and rectum of rabbits caught during the night had considerably less VFA than did the soft pellets from rabbits caught during the day.4. Owing to the ingestion of soft faeces, the VFA content of stomach material was greater in rabbits caught during the day than in those caught at night.5. The results are discussed in terms of the mechanism of the diurnal excretion pattern and the role of coprophagy in the rabbit.

scholarly journals Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Akihito Nakajima ◽  
Tomoyoshi Shibuya ◽  
Takashi Sasaki ◽  
Yu Jie Lu ◽  
Dai Ishikawa ◽  
...  
Keyword(s):  
Oral Administration ◽  
Potential Role ◽  
Distal Colon ◽  
Short Chain Fatty Acids ◽  
Proximal Colon ◽  
Gut Contents ◽  
Male Mice ◽  
Histological Changes ◽  
Nicotine Administration ◽  
Colon And Rectum

Nicotine affects the gastrointestinal environment and modulates ulcerative colitis (UC). However, the associations among nicotine, gut metabolites, and UC are still largely unknown. We investigated whether orally administered nicotine affected gut metabolites and dextran sodium sulfate (DSS)-induced colitis. C57BL/6 male mice were orally administered nicotine solution in drinking water prior to inducing DSS-induced colitis. Short-chain fatty acids (SCFAs) and indole in gut contents and fecal samples were measured by GC-MS and hydroxylamine-based indole assays, respectively. Oral administration of nicotine increased indole concentration in feces, but, in contrast, SCFA values did not differ with nicotine administration. Indole levels were increased in the distal colon and rectum but not in the cecum and proximal colon. DSS-induced colitis was less severe clinically and histological changes were minimal in the rectum of orally nicotine-administered mice compared to mice drinking only water. 16S rRNA microbiome on the feces revealed an increasing in Clostridium and Porphyromonas in nicotine-administered mice. In conclusion, nicotine administration was associated with increased indole levels in the distal colon and rectum and attenuated DSS-induced colitis. Oral administration of nicotine may play a potential role in indole upregulation and prevention of UC.

scholarly journals Studies of the large intestine of sheep

1983 ◽  
Vol 50 (3) ◽  
pp. 757-768 ◽  
Author(s):  
R. M. Dixon ◽  
J. V. Nolan
Keyword(s):  
Medicago Sativa ◽  
Large Intestine ◽  
Intravenous Infusion ◽  
Distal Colon ◽  
Proximal Colon ◽  
Irreversible Loss ◽  
Plasma Urea ◽  
Pool Model ◽  
Colon And Rectum ◽  
Microbial N

1. A study was made of nitrogen kinetics in the large intestine of sheep given 800 g chopped lucerne (Medicago sativa) hay/d. Four sheepwere continuously infused with (15NH4)2SO4 into the caecum and three other sheep were infused intravenously with [15N]urea. A digesta marker, 51Cr complexed with EDTA (51Cr-EDTA), was infused into the rumen of each sheep to allow estimation of the rates of flow of digesta constituents. Infusions were continued until tracer concentrations reached plateaux in digesta and blood pools, after which the sheep were anaesthetized and slaughtered.2. Pre-infusion samples and samples on plateau were obtained before slaughter for subsequent analysis to give plasma urea and rumen ammonia-N concentration and enrichment. At slaughter, digesta were obtained from the ileum and segments of the large intestine. These were analysed for 51Cr-EDTA content and concentration and enrichment of ammonia-N, microbial N and non-urea non-ammonia-N (NU-NAN).3. N flows in segments of the large intestine were calculated and represented in a quantitative eight-pool model.4. Transfer of plasma urea across the wall of the caecum and proximal colon was negligible but there was an input of 0·8 g endogenous NU-NAN/d.5. Flow of urea plus ammonia-N in digesta from the ileum into the caecum contributed 1·0 g N/d to the caecal ammonia pool.6. Proteolysis and deamination produced a further 3·0 g ammonia-N/d in the caecum and proximal colon.7. The net absorption of N between the ileum and the rectum was 2·8 g N/d but 3·0 g ammonia-N/d was absorbed from the caecum and proximal colon and, in addition, at least 0·9 g ammonia-N/d from the distal colon and rectum.8. Ammonia-N was incorporated into caecal microbes (0·6 g N/d) and approximately 57% of the NU-NAN in caecal digesta was microbial N. The majority of the microbial N flowing from the caecum was excreted in faeces.9. The rate of irreversible loss of urea-N from plasma, measured by intravenous infusion of [15N]urea, was 13·6 g/d. On average 83 (SE 6·8)% of the 15NH3 apparently absorbed from the caecum was incorporated into plasma urea; caecal ammonia contributed 9–19% of the N in plasma urea and 0·2–3·1% of the N in rumen ammonia.

Regular consumption of red meat and health behaviors in the Brazilian population

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D de Assumpção ◽  
S M Álvares Domene ◽  
A M Pita Ruiz ◽  
P M Stolses Bergamo Francisco
Keyword(s):  
Physical Activity ◽  
Health Behaviors ◽  
Meat Consumption ◽  
Cross Sectional Study ◽  
National Health Survey ◽  
Red Meat ◽  
Alcoholic Beverages ◽  
Cross Sectional ◽  
Unhealthy Eating ◽  
Regular Consumption

Abstract Background The consumption of red meat should not surpass 500 g of cooked weight per week. Regular consumption can exceed this recommendation, increasing the risk of chronic diseases. Objective Estimate the prevalence of the regular consumption of red meat according to health behaviors in Brazilian adults (≥18 years). Methods A cross-sectional study was conducted with data from the 2013 National Health Survey, which is a household inquiry with a representative sample of the population ≥18 years of age. The regular consumption of red meat (beef, pork, goat) was defined as ≥ 5 days/week. Prevalence ratios (PR) and 95% confidence intervals (CI) were estimated according to health behaviors (healthy and unhealthy eating patterns, smoking, practice of physical activity during leisure and alcohol intake). Results A total of 60,202 adults were interviewed, 52.9% of whom were women and mean age was 42.9 years (95%CI: 42.6-43.2). The prevalence of regular red meat consumption was 36.7% (95%CI: 36.0-37.5) and was higher among those who ingested soft drinks/artificial juice (PR = 1.08) and sweets (PR = 1.05) ≥3 days/week, ingested beans (PR = 1.07) and raw vegetables (PR = 1.03) ≥5 days/week, ingested fatty meat (PR = 1.09), smokers (PR = 1.05), individuals who were inactive during leisure (PR = 1.04) and those who consumed alcohol ≥2 times/week (PR = 1.06). The prevalence was lower among those who ate fruit (PR = 0.99) and chicken (PR = 0.95) ≥5 days/week, those who ate fish (PR = 0.90) at least 1 day/week and those who drank no fat/low fat milk rather than whole milk. Conclusions The regular consumption of red meat was higher among individuals who ingested unhealthy foods more often, those who ingested fatty meat, smokers, those who ingested alcoholic beverages and those who did not practice physical activity. Actions are needed to reduce the frequency of red meat consumption. Key messages Regular consumption of red meat can exceed the recommendation of 500 g of cooked weight per week. The regular consumption of red meat was associated with the more frequent ingestion of unhealthy foods and fatty meat.

scholarly journals The Relationship between Inflammation Markers (CRP, IL-6, sCD40L) and Colorectal Cancer Stage, Grade, Size and Location

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1382
Author(s):  
Olga Martyna Koper-Lenkiewicz ◽  
Violetta Dymicka-Piekarska ◽  
Anna Justyna Milewska ◽  
Justyna Zińczuk ◽  
Joanna Kamińska
Keyword(s):  
Colorectal Cancer ◽  
Linear Regression ◽  
Tumor Size ◽  
Distal Colon ◽  
Proximal Colon ◽  
Model Parameters ◽  
Grade Group ◽  
Who Grade ◽  
The Mean ◽  
Mean Concentration

The aim of the study was the evaluation whether in primary colorectal cancer (CRC) patients (n = 55): age, sex, TNM classification results, WHO grade, tumor location (proximal colon, distal colon, rectum), tumor size, platelet count (PLT), mean platelet volume (MPV), mean platelet component (MCP), levels of carcinoembryonic antigen (CEA), cancer antigen (CA 19-9), as well as soluble lectin adhesion molecules (L-, E-, and P-selectins) may influence circulating inflammatory biomarkers: IL-6, CRP, and sCD40L. We found that CRP concentration evaluation in routine clinical practice may have an advantage as a prognostic biomarker in CRC patients, as this protein the most comprehensively reflects clinicopathological features of the tumor. Univariate linear regression analysis revealed that in CRC patients: (1) with an increase in PLT by 10 × 103/μL, the mean concentration of CRP increases by 3.4%; (2) with an increase in CA 19-9 of 1 U/mL, the mean concentration of CRP increases by 0.7%; (3) with the WHO 2 grade, the mean CRP concentration increases 3.631 times relative to the WHO 1 grade group; (4) with the WHO 3 grade, the mean CRP concentration increases by 4.916 times relative to the WHO 1 grade group; (5) with metastases (T1-4N+M+) the mean CRP concentration increases 4.183 times compared to non-metastatic patients (T1-4N0M0); (6) with a tumor located in the proximal colon, the mean concentration of CRP increases 2.175 times compared to a tumor located in the distal colon; (7) in patients with tumor size > 3 cm, the CRP concentration is about 2 times higher than in patients with tumor size ≤ 3 cm. In the multivariate linear regression model, the variables that influence the mean CRP value in CRC patients included: WHO grade and tumor localization. R2 for the created model equals 0.50, which indicates that this model explains 50% of the variance in the dependent variable. In CRC subjects: (1) with the WHO 2 grade, the mean CRP concentration rises 3.924 times relative to the WHO 1 grade; (2) with the WHO 3 grade, the mean CRP concentration increases 4.721 times in relation to the WHO 1 grade; (3) with a tumor located in the rectum, the mean CRP concentration rises 2.139 times compared to a tumor located in the distal colon; (4) with a tumor located in the proximal colon, the mean concentration of CRP increases 1.998 times compared to the tumor located in the distal colon; if other model parameters are fixed.

scholarly journals Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers

Gut ◽  
2021 ◽  
pp. gutjnl-2020-322545
Author(s):  
Han-Mo Chiu ◽  
Grace Hsiao-Hsuan Jen ◽  
Ying-Wei Wang ◽  
Jean Ching-Yuan Fann ◽  
Chen-Yang Hsu ◽  
...  
Keyword(s):  
Large Scale ◽  
Distal Colon ◽  
Population Based ◽  
Proximal Colon ◽  
Advanced Stage ◽  
Site Specific ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test ◽  
Selection Factors

ObjectiveTo measure the effects of faecal immunochemical test (FIT) for colorectal cancer (CRC) screening on overall and site-specific long-term effectiveness of population-based organised service screening.DesignA prospective cohort study of Taiwanese nationwide biennial FIT screening was performed. A total of 5 417 699 eligible subjects were invited to attend screening from 2004 through 2009 and were followed up until 2014. We estimated the adjusted relative rates (aRRs) on the effectiveness of reducing advanced-stage CRC (stage II+) and CRC death by Bayesian Poisson regression models with the full adjustment for a cascade of self-selection factors (including the screening rate and the colonoscopy rate) and the completeness of colonoscopy together with demographic features.ResultsFIT screening (exposed vs unexposed) reduced the incidence of advanced-stage CRC (48.4 vs 75.7 per 100 000) and mortality (20.3 vs 41.3 per 100 000). Statistically significant reductions of both incidence of advanced-stage CRCs (aRR=0.66, 95% CI 0.63 to 0.70) and deaths from CRC (aRR=0.60, 95% CI 0.57 to 0.64) were noted. FIT screening was more effective in reducing distal advanced-stage CRCs (aRR=0.61, 95% CI 0.58 to 0.64) and CRC mortality (aRR=0.56, 95% CI 0.53 to 0.69) than proximal advanced CRCs (aRR=0.84, 95% CI 0.77 to 0.92) and CRC mortality (aRR=0.72, 95% CI 0.66 to 0.80).ConclusionA large-scale population-based biennial FIT screening demonstrates 34% significant reduction of advanced-stage CRCs and 40% reduction of death from CRC with larger long-term effectiveness in the distal colon than the proximal colon. Our findings provide a strong and consistent evidence-based policy for supporting a sustainable population-based FIT organised service screening worldwide. The disparity of site-specific long-term effectiveness also provides an insight into the remedy for lower effectiveness of FIT screening in the proximal colon.

scholarly journals Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Nick J. Spencer ◽  
Lee Travis ◽  
Lukasz Wiklendt ◽  
Marcello Costa ◽  
Timothy J. Hibberd ◽  
...  
Keyword(s):  
Nervous System ◽  
Smooth Muscle ◽  
Enteric Nervous System ◽  
Lymphatic Vessels ◽  
Distal Colon ◽  
Distal Region ◽  
Proximal Colon ◽  
Synchronous Firing ◽  
Electrophysiological Recordings ◽  
Intrinsic Neurons

AbstractHow the Enteric Nervous System (ENS) coordinates propulsion of content along the gastrointestinal (GI)-tract has been a major unresolved issue. We reveal a mechanism that explains how ENS activity underlies propulsion of content along the colon. We used a recently developed high-resolution video imaging approach with concurrent electrophysiological recordings from smooth muscle, during fluid propulsion. Recordings showed pulsatile firing of excitatory and inhibitory neuromuscular inputs not only in proximal colon, but also distal colon, long before the propagating contraction invades the distal region. During propulsion, wavelet analysis revealed increased coherence at ~2 Hz over large distances between the proximal and distal regions. Therefore, during propulsion, synchronous firing of descending inhibitory nerve pathways over long ranges aborally acts to suppress smooth muscle from contracting, counteracting the excitatory nerve pathways over this same region of colon. This delays muscle contraction downstream, ahead of the advancing contraction. The mechanism identified is more complex than expected and vastly different from fluid propulsion along other hollow smooth muscle organs; like lymphatic vessels, portal vein, or ureters, that evolved without intrinsic neurons.

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