Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines

2003 ◽  
Vol 108 (6) ◽  
pp. 812-817 ◽  
Author(s):  
Elisa Messina ◽  
Paola Gazzaniga ◽  
Vanna Micheli ◽  
Maria Rosaria Guaglianone ◽  
Silvia Barbato ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Guanine Nucleotide ◽  
Human Neuroblastoma ◽  
Cycle Arrest ◽  
Neuroblastoma Cell Lines

MCPIP1 overexpression in human neuroblastoma cell lines causes cell‐cycle arrest by G1/S checkpoint block

2020 ◽  
Vol 121 (5-6) ◽  
pp. 3406-3425 ◽  
Author(s):  
Elżbieta Boratyn ◽  
Iwona Nowak ◽  
Elżbieta Karnas ◽  
Damian Ryszawy ◽  
Dawid Wnuk ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Cycle Arrest ◽  
Neuroblastoma Cell Lines

1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) Alters Cell Cycle Progression in Human Neuroblastoma Cell Lines

2017 ◽  
Vol 32 (4) ◽  
pp. 649-660 ◽  
Author(s):  
Rakesh Kumar Sharma ◽  
Eduardo Candelario-Jalil ◽  
Doris Feineis ◽  
Gerhard Bringmann ◽  
Bernd L. Fiebich ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Lines ◽  
Cell Cycle Progression ◽  
Neuroblastoma Cell ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Cycle Progression ◽  
Neuroblastoma Cell Lines

scholarly journals The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma

2021 ◽  
Vol 22 (12) ◽  
pp. 6565
Author(s):  
Jennifer H. Foster ◽  
Eveline Barbieri ◽  
Linna Zhang ◽  
Kathleen A. Scorsone ◽  
Myrthala Moreno-Smith ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Wild Type ◽  
Tumor Weight ◽  
Cycle Arrest ◽  
P53 Status ◽  
Neuroblastoma Cell Lines ◽  
Anti Tumor Activity

Pevonedistat is a neddylation inhibitor that blocks proteasomal degradation of cullin–RING ligase (CRL) proteins involved in the degradation of short-lived regulatory proteins, including those involved with cell-cycle regulation. We determined the sensitivity and mechanism of action of pevonedistat cytotoxicity in neuroblastoma. Pevonedistat cytotoxicity was assessed using cell viability assays and apoptosis. We examined mechanisms of action using flow cytometry, bromodeoxyuridine (BrDU) and immunoblots. Orthotopic mouse xenografts of human neuroblastoma were generated to assess in vivo anti-tumor activity. Neuroblastoma cell lines were very sensitive to pevonedistat (IC50 136–400 nM). The mechanism of pevonedistat cytotoxicity depended on p53 status. Neuroblastoma cells with mutant (p53MUT) or reduced levels of wild-type p53 (p53si-p53) underwent G2-M cell-cycle arrest with rereplication, whereas p53 wild-type (p53WT) cell lines underwent G0-G1 cell-cycle arrest and apoptosis. In orthotopic neuroblastoma models, pevonedistat decreased tumor weight independent of p53 status. Control mice had an average tumor weight of 1.6 mg + 0.8 mg versus 0.5 mg + 0.4 mg (p < 0.05) in mice treated with pevonedistat. The mechanism of action of pevonedistat in neuroblastoma cell lines in vitro appears p53 dependent. However, in vivo studies using mouse neuroblastoma orthotopic models showed a significant decrease in tumor weight following pevonedistat treatment independent of the p53 status. Novel chemotherapy agents, such as the NEDD8-activating enzyme (NAE) inhibitor pevonedistat, deserve further study in the treatment of neuroblastoma.

Delta opioid receptor in human neuroblastoma cell lines

1986 ◽  
Vol 382 (2) ◽  
pp. 327-331 ◽  
Author(s):  
Günther Hochhaus ◽  
Victor C. Yu ◽  
Wolfgang Sadée
Keyword(s):  
Opioid Receptor ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Delta Opioid Receptor ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines

Ciliary neurotrophic factor-induced gene expression in human neuroblastoma cell lines

1995 ◽  
Vol 20 (6) ◽  
pp. 675-680 ◽  
Author(s):  
P. Rossino ◽  
G. Volpe ◽  
A. Negro ◽  
L. Callegaro ◽  
F. Altruda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Neurotrophic Factor ◽  
Neuroblastoma Cell ◽  
Ciliary Neurotrophic Factor ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Neuroblastoma Cell Lines
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