scholarly journals Trajectories of class–switching‐related egg and cow's milk allergen‐specific immunoglobulin isotype formation and its modification by eczema with low‐ and high‐affinity immunoglobulin E during early infancy

2019 ◽  
Vol 7 (2) ◽  
pp. 74-85 ◽  
Author(s):  
Makoto Irahara ◽  
Wakako Shinahara ◽  
Mayumi Sugimoto ◽  
Yukiko Ogawa ◽  
Keiji Shitsukawa ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Early Infancy ◽  
Cow’S Milk ◽  
Class Switching ◽  
Immunoglobulin Isotype ◽  
Cow's Milk ◽  
High Affinity ◽  
Specific Immunoglobulin

MILK-SPECIFIC IMMUNOGLOBULIN E/TOTAL IMMUNOGLOBULIN E RATIO AS A PREDICTOR OF POSITIVE ORAL FOOD CHALLENGES IN CHILDREN WITH ALLERGY TO COW'S MILK

PEDIATRICS ◽  
2008 ◽  
Vol 121 (Supplement 2) ◽  
pp. S92.2-S92
Author(s):  
George Konstantinou ◽  
Alexandra Kalobatsou ◽  
Maria Koutli ◽  
Paraskevi Xepapadaki ◽  
Nikolaos Douladiris ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Food Challenges ◽  
Total Immunoglobulin

Differential Cytokine Expression in the Duodenum and Rectum of Children with Non-Immunoglobulin E-Mediated Cow’s Milk Protein Allergy

2021 ◽  
Author(s):  
Erick M. Toro-Monjaraz ◽  
Gabriela Fonseca-Camarillo ◽  
Flora Zárate-Mondragón ◽  
Ericka Montijo-Barrios ◽  
José Cadena-León ◽  
...  
Keyword(s):  
Milk Protein ◽  
Immunoglobulin E ◽  
Cytokine Expression ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Protein

Characteristics and Laboratory Findings of Food-Induced Anaphylaxis in Children: Study in an Asian Developing Country

2021 ◽  
pp. 1-9
Author(s):  
Rapisa Nantanee ◽  
Narissara Suratannon ◽  
Pantipa Chatchatee
Keyword(s):  
Developing Country ◽  
Immunoglobulin E ◽  
Tertiary Care ◽  
Elevated Serum ◽  
Cow’S Milk ◽  
Care Hospital ◽  
Serum Tryptase ◽  
Cutaneous Manifestations ◽  
Cow's Milk ◽  
Geographical Regions

<b><i>Introduction:</i></b> Food allergy is the major cause of pediatric anaphylaxis. Characteristics and triggers may be different in different geographical regions. Studies focusing on food-induced anaphylaxis (FIA) in Asian developing countries are limited. Our study aimed to study characteristics of FIA in a tertiary care center in an Asian developing country. <b><i>Methods:</i></b> Retrospective review of pediatric anaphylaxis admission and outpatient visit at a tertiary care hospital in Bangkok, Thailand during 2008–2018 was performed. Data regarding clinical presentation, place reaction occurred, time of onset, investigations (serum tryptase, specific immunoglobulin E, and skin test), treatment, and follow-up periods were collected. <b><i>Results:</i></b> One hundred seventy-four anaphylaxis admission records of which 61 episodes of FIA were retrieved. Data from outpatients visit consisted of 17 patients. Most patients were male (76.7%). The median age was 7.1 years (interquartile range 1.9–12.4). The major causes of FIA were shrimp/shellfish (37%), wheat (15.1%), and cow’s milk (11%). Food causing anaphylaxis varied according to age-group: infants had anaphylactic reactions to egg, wheat, and cow’s milk, preschools to wheat and peanut, and older children to shrimp/shellfish. Cutaneous manifestations occurred in all patients, followed by lower respiratory tract symptoms (83.6%) and gastrointestinal symptoms (50.8%). There was no biphasic anaphylaxis reported. Elevated serum tryptase was found in only 4 patients (7%). <b><i>Conclusion:</i></b> Recognizing characteristics of pediatric FIA is crucial. The common causes of FIA in our study in Asian children were egg in infants, wheat and peanut in preschool children, and shrimp/shellfish in school-age children and adolescents. Skin manifestation presented in all patients with FIA.

scholarly journals Testing the Cow’s Milk-Related Symptom Score (CoMiSSTM) for the Response to a Cow’s Milk-Free Diet in Infants: A Prospective Study

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2402 ◽  
Author(s):  
Silvia Salvatore ◽  
Elisabetta Bertoni ◽  
Federica Bogni ◽  
Valentina Bonaita ◽  
Chiara Armano ◽  
...  
Keyword(s):  
Symptom Score ◽  
Immunoglobulin E ◽  
Gastrointestinal Symptoms ◽  
Cow’S Milk ◽  
P Value ◽  
Cow's Milk ◽  
Related Symptom ◽  
Receiver Operation Characteristic ◽  
Ige Mediated ◽  
A Prospective Study

The diagnosis of cow’s milk allergy (CMA) is particularly challenging in infants, especially with non-Immunoglobulin E (IgE)-mediated manifestations, and inaccurate diagnosis may lead to unnecessary dietary restrictions. The aim of this study was to assess the accuracy of the cow’s milk-related symptom score (CoMiSSTM) in response to a cow’s milk-free diet (CMFD). We prospectively recruited 47 infants (median age three months) who had been placed on a CMFD due to persisting unexplained gastrointestinal symptoms. We compared data with 94 healthy controls (median age three months). The CoMiSSTM score was completed at recruitment and while on the exclusion diet. In 19/47 (40%) cases a response to the diet occurred. At recruitment CoMiSSTM was significantly higher in cases compared to controls (median score 8 vs. 3; p-value: <0.05), 9 cases had a score ≥12 and 8/9 normalized on CMFD. An oral milk challenge was performed in all 19 responders and six of these had a positive reaction to cow’s milk (CM). In eight infants IgE allergy tests were positive. The receiver operation characteristic (ROC) curve identified a CoMISSTM score of 9 to be the best cut-off value (84% sensitivity, 85% specificity, 80% positive (PPV) and 88% negative predictive value (NPV)) for the response to CMFD. We found CoMiSSTM to be a useful tool to help identify infants with persisting gastrointestinal symptoms and suspected CMA that would benefit from CMFD.

Feeding a soy formula to children with cow's milk allergy: The development of immunoglobulin E-mediated allergy to soy and peanuts

2005 ◽  
Vol 16 (8) ◽  
pp. 641-646 ◽  
Author(s):  
Timo Klemola ◽  
Kirsti Kalimo ◽  
Tuija Poussa ◽  
Kaisu Juntunen-Backman ◽  
Riitta Korpela ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy
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