An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertraline

2008 ◽  
Vol 23 (3) ◽  
pp. 231-241 ◽  
Author(s):  
Valérie Guille ◽  
Rodney J. Croft ◽  
Barry V. O'Neill ◽  
Susan Illic ◽  
K. Luan Phan ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Serotonergic Neurotransmission ◽  
Dependence Measure ◽  
Loudness Dependence ◽  
Evoked Activity ◽  
Acute Changes

Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity

2003 ◽  
Vol 64 (2-3) ◽  
pp. 115-124 ◽  
Author(s):  
Georg Juckel ◽  
Jürgen Gallinat ◽  
Michael Riedel ◽  
Safet Sokullu ◽  
Carl Schulz ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Primary Auditory Cortex ◽  
Dependence Measure ◽  
Loudness Dependence ◽  
Evoked Activity ◽  
Serotonergic Dysfunction

Spontaneous activity resembling tone-evoked activity in the primary auditory cortex of guinea pigs

2010 ◽  
Vol 68 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Kazuya Saitoh ◽  
Shinji Inagaki ◽  
Masataka Nishimura ◽  
Hideo Kawaguchi ◽  
Wen-Jie Song
Keyword(s):  
Auditory Cortex ◽  
Spontaneous Activity ◽  
Guinea Pigs ◽  
Primary Auditory Cortex ◽  
Evoked Activity

Predictable tones elicit stimulus-specific suppression of evoked activity in auditory cortex

NeuroImage ◽  
2019 ◽  
Vol 200 ◽  
pp. 242-249 ◽  
Author(s):  
Biao Han ◽  
Pim Mostert ◽  
Floris P. de Lange
Keyword(s):  
Auditory Cortex ◽  
Specific Suppression ◽  
Evoked Activity

Functional change of the auditory cortex related to brain serotonergic neurotransmission in type 1 diabetic adolescents with and without depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 323-323
Author(s):  
G. Manjarrez ◽  
R. Herrera ◽  
J. Manjarrez ◽  
S. Mejenes ◽  
J. Hernandez-R
Keyword(s):  
Auditory Cortex ◽  
Auditory Evoked Potentials ◽  
Free Fraction ◽  
Functional Change ◽  
Diabetic Patients ◽  
Serotonergic Activity ◽  
Serotonergic Neurotransmission ◽  
Poor Treatment ◽  
Plasma Free Fraction

ObjectiveThe aim of this study was to determine whether diabetic patients who were depressed present a decrease of brain serotonergic activity compared to diabetic patients without depression or patients with depression but without diabetes. Determination was made with plasma free fraction of l-tryptophan (FFT) and intensity-dependent auditory-evoked potentials (IDAEPs).MethodsThirty seven adolescents were studied (20 type 1 diabetic subjects: 9 with depression, 11 without depression), 9 controls and 8 subjects with only depression. FFT, glucose, glycated hemoglobin, free fatty acids, albumin and IDAEPs were determined.ResultAll diabetic patients showed a significant decrease of FFT. The group diabetic subjects with depression presented a steeper slope of the amplitude-intensity function of N1/P2 component, suggesting a higher reactivity of the auditory cortex in comparison to diabetic subjects without depression, subjects with only depression, and controls. This was associated with lower plasma FFT. Diabetic subjects with depression had a deficiency of metabolic control due to poor treatment adherence.ConclusionsThese findings suggest an enhanced deterioration of brain serotonergic neurotransmission in diabetic subjects with depression with abnormal responses of the auditory cortex. The N1/P2 component of IDAEP is proposed as a noninvasive indicator of brain serotonergic tone that differentiates depressed from nondepressed diabetic patients.

Functional change of the auditory cortex related to brain serotonergic neurotransmission in type 1 diabetic adolescents with and without depression

2009 ◽  
Vol 10 (4-3) ◽  
pp. 877-883 ◽  
Author(s):  
Gabriel Manjarrez-Gutierrez ◽  
Rocio Herrera Marquez ◽  
Susana A. Mejenes-Alvarez ◽  
Teresa Godinez-Lopez ◽  
Jorge Hernandez-R
Keyword(s):  
Auditory Cortex ◽  
Functional Change ◽  
Serotonergic Neurotransmission

scholarly journals Development of neural responsivity to vocal sounds in higher level auditory cortex of songbirds

2014 ◽  
Vol 112 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Vanessa C. Miller-Sims ◽  
Sarah W. Bottjer
Keyword(s):  
Auditory Cortex ◽  
Vocal Learning ◽  
Response Strength ◽  
Neural Mechanisms ◽  
Sensitive Period ◽  
Unexpected Result ◽  
Salient Stimulus ◽  
Evoked Activity ◽  
High Level ◽  
Persistent Response

Like humans, songbirds learn vocal sounds from “tutors” during a sensitive period of development. Vocal learning in songbirds therefore provides a powerful model system for investigating neural mechanisms by which memories of learned vocal sounds are stored. This study examined whether NCM (caudo-medial nidopallium), a region of higher level auditory cortex in songbirds, serves as a locus where a neural memory of tutor sounds is acquired during early stages of vocal learning. NCM neurons respond well to complex auditory stimuli, and evoked activity in many NCM neurons habituates such that the response to a stimulus that is heard repeatedly decreases to approximately one-half its original level (stimulus-specific adaptation). The rate of neural habituation serves as an index of familiarity, being low for familiar sounds, but high for novel sounds. We found that response strength across different song stimuli was higher in NCM neurons of adult zebra finches than in juveniles, and that only adult NCM responded selectively to tutor song. The rate of habituation across both tutor song and novel conspecific songs was lower in adult than in juvenile NCM, indicating higher familiarity and a more persistent response to song stimuli in adults. In juvenile birds that have memorized tutor vocal sounds, neural habituation was higher for tutor song than for a familiar conspecific song. This unexpected result suggests that the response to tutor song in NCM at this age may be subject to top-down influences that maintain the tutor song as a salient stimulus, despite its high level of familiarity.

scholarly journals Dissociation of task engagement and arousal effects in auditory cortex and midbrain

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Daniela Saderi ◽  
Zachary P Schwartz ◽  
Charles R Heller ◽  
Jacob R Pennington ◽  
Stephen V David
Keyword(s):  
Auditory Cortex ◽  
Auditory Processing ◽  
Generalized Linear Model ◽  
Pupil Size ◽  
Primary Auditory Cortex ◽  
Task Engagement ◽  
State Variables ◽  
Neural Populations ◽  
Evoked Activity ◽  
Sensory Neural

Both generalized arousal and engagement in a specific task influence sensory neural processing. To isolate effects of these state variables in the auditory system, we recorded single-unit activity from primary auditory cortex (A1) and inferior colliculus (IC) of ferrets during a tone detection task, while monitoring arousal via changes in pupil size. We used a generalized linear model to assess the influence of task engagement and pupil size on sound-evoked activity. In both areas, these two variables affected independent neural populations. Pupil size effects were more prominent in IC, while pupil and task engagement effects were equally likely in A1. Task engagement was correlated with larger pupil; thus, some apparent effects of task engagement should in fact be attributed to fluctuations in pupil size. These results indicate a hierarchy of auditory processing, where generalized arousal enhances activity in midbrain, and effects specific to task engagement become more prominent in cortex.

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