Evaluation of the development of acute tolerance to the psychomotor effects of midazolam following intravenous infusions in healthy volunteers

1995 ◽  
Vol 10 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Joseph C. Fleishaker ◽  
James H. Chambers ◽  
Gary R. Peters
Keyword(s):  
Healthy Volunteers ◽  
Acute Tolerance ◽  
Psychomotor Effects ◽  
Intravenous Infusions

Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers

1996 ◽  
Vol 54 (2) ◽  
pp. 501-508 ◽  
Author(s):  
Santosh Yajnik ◽  
James P. Zacny ◽  
Christopher J. Young ◽  
J.Lance Lichtor ◽  
Gita Rupani ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Healthy Volunteers ◽  
Acute Tolerance ◽  
Tolerance Development ◽  
Psychomotor Effects

Behavioral and Physiological Effects of Remifentanil and Alfentanil in Healthy Volunteers 

1999 ◽  
Vol 90 (3) ◽  
pp. 718-726 ◽  
Author(s):  
Matthew L. Black ◽  
Joanna L. Hill ◽  
James P. Zacny
Keyword(s):  
Healthy Volunteers ◽  
Dose Range ◽  
Subjective Effects ◽  
Cold Pressor Test ◽  
Drug Effects ◽  
Cold Pressor ◽  
Psychomotor Tests ◽  
Potency Ratio ◽  
Psychomotor Effects ◽  
Double Blinded

Background The subjective and psychomotor effects of remifentanil have not been evaluated. Accordingly, the authors used mood inventories and psychomotor tests to characterize the effects of remifentanil in healthy, non-drug-abusing volunteers. Alfentanil was used as a comparator drug. Methods Ten healthy volunteers were enrolled in a randomized, double-blinded, placebo-controlled, crossover trial in which they received an infusion of saline, remifentanil, or alfentanil for 120 min. The age- and weight-adjusted infusions (determined with STANPUMP, a computer modeling software package) were given to achieve three predicted constant plasma levels for 40 min each of remifentanil (0.75, 1.5, and 3 ng/ml) and alfentanil (16, 32, and 64 ng/ml). Mood forms and psychomotor tests were completed, and miosis was assessed, during and after the infusions. In addition, analgesia was tested at each dose level using a cold-pressor test. Results Remifentanil had prototypic micro-like opioid subjective effects, impaired psychomotor performance, and produced analgesia. Alfentanil at the dose range tested had more mild effects on these measures, and the analgesia data indicated that a 40:1 potency ratio, rather than the 20:1 ratio we used, may exist between remifentanil and alfentanil. A psychomotor test administered 60 min after the remifentanil infusion was discontinued showed that the volunteers were still impaired, although they reported feeling no drug effects. Conclusions The notion that the pharmacodynamic effects of remifentanil are extremely short-lived after the drug is no longer administered must be questioned given our findings that psychomotor effects were still apparent 1 h after the infusion was discontinued.

The Psychomotor Effects of Carbamazepine in Epileptic Patients and Healthy Volunteers

2003 ◽  
Vol 17 (3) ◽  
pp. 269-272 ◽  
Author(s):  
M. S. M. Pieters ◽  
A. F. van Steveninck ◽  
R. C. Schoemaker ◽  
J. M. Kroon ◽  
J. M. A. van Gerven ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Psychomotor Effects ◽  
Epileptic Patients

Time taken for safe manual intravenous infusions of up to 100 ml saline to healthy volunteers

2001 ◽  
Vol 15 (5) ◽  
pp. 227-229
Author(s):  
M.V. Cantarini ◽  
G. Hooper ◽  
R.M. Braybrooke ◽  
J.A. Lockton ◽  
A.M. Hughes
Keyword(s):  
Healthy Volunteers ◽  
Intravenous Infusions

Psychomotor Effects of Diazepam in Anxious Patients and Healthy Volunteers

1983 ◽  
Vol 3 (2) ◽  
pp. 88???96 ◽  
Author(s):  
MARKKU LINNOILA ◽  
CHARLES W. ERWIN ◽  
ANDREA BRENDLE ◽  
DALE SIMPSON
Keyword(s):  
Healthy Volunteers ◽  
Psychomotor Effects

Comparative cognitive and psychomotor effects of single doses of Valeriana officianalis and triazolam in healthy volunteers

2003 ◽  
Vol 18 (8) ◽  
pp. 619-625 ◽  
Author(s):  
Karen T. Hallam ◽  
James S. Olver ◽  
Caroline McGrath ◽  
Trevor R. Norman
Keyword(s):  
Healthy Volunteers ◽  
Psychomotor Effects

Subjective and Psychomotor Effects of Nitrous Oxide in Healthy Volunteers

1994 ◽  
Vol 38 (5) ◽  
pp. 258
Author(s):  
C. S. DOHRN ◽  
J. L. LICHTOR ◽  
R. S. FINN ◽  
A. UITVLUGT ◽  
D. W. COALSON ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Healthy Volunteers ◽  
Psychomotor Effects
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