Cognitive effects of long-term benzodiazepine use in older adults

2003 ◽  
Vol 18 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Mary Pat McAndrews ◽  
Rachel T. Weiss ◽  
Paul Sandor ◽  
Ann Taylor ◽  
Peter L. Carlen ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Effects ◽  
Benzodiazepine Use

An evaluation of persisting cognitive effects after withdrawal from long-term benzodiazepine use

2005 ◽  
Vol 11 (3) ◽  
pp. 281-289 ◽  
Author(s):  
MELINDA J. BARKER ◽  
KENNETH M. GREENWOOD ◽  
MARTIN JACKSON ◽  
SIMON F. CROWE
Keyword(s):  
Verbal Memory ◽  
Neuropsychological Tests ◽  
Control Group ◽  
Cognitive Effects ◽  
Control Performance ◽  
Nonverbal Memory ◽  
Visuospatial Skills ◽  
Benzodiazepine Use ◽  
Anxiety Levels

Twenty participants with self-reported long-term benzodiazepine use (mean 108 months) who had previously withdrawn from medication (mean 42 months) were administered a battery of neuropsychological tests. Each long-term user was case matched for age, sex, and education to two control participants who reported never taking benzodiazepines (those with and those without anxiety). The results indicated that long-term benzodiazepine use may lead to impairments in the areas of verbal memory, motor control/performance, and nonverbal memory but not visuospatial skills and attention/concentration. The length of abstinence (> 6 months) indicates that these impairments persist well beyond cessation of benzodiazepine use. However, observed impairments in the area of nonverbal memory were not solely attributable to benzodiazepine use and may be influenced by the elevated anxiety levels present in both the case and the anxious control group. (JINS, 2005,11, 281–289.)

Cognitive effects of pregabalin in the treatment of long-term benzodiazepine-use and dependence

2014 ◽  
Vol 29 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Panagiotis Oulis ◽  
Stamatina Kalogerakou ◽  
Eleni Anyfandi ◽  
George Konstantakopoulos ◽  
Vassiliki-Maria Papakosta ◽  
...  
Keyword(s):  
Cognitive Effects ◽  
Benzodiazepine Use

Cognitive Effects of Long-Term Benzodiazepine Use

CNS Drugs ◽  
2004 ◽  
Vol 18 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Melinda J Barker ◽  
Kenneth M Greenwood ◽  
Martin Jackson ◽  
Simon F Crowe
Keyword(s):  
Cognitive Effects ◽  
Benzodiazepine Use

scholarly journals Factors Associated With Long-term Benzodiazepine Use Among Older Adults

2018 ◽  
Vol 178 (11) ◽  
pp. 1560 ◽  
Author(s):  
Lauren B. Gerlach ◽  
Donovan T. Maust ◽  
Shirley H. Leong ◽  
Shahrzad Mavandadi ◽  
David W. Oslin
Keyword(s):  
Older Adults ◽  
Factors Associated ◽  
Benzodiazepine Use

scholarly journals Long-term use of benzodiazepines in older patients in Germany: a retrospective analysis

2017 ◽  
Vol 7 (6-7) ◽  
pp. 191-200 ◽  
Author(s):  
Louis Jacob ◽  
Michael A. Rapp ◽  
Karel Kostev
Keyword(s):  
Older Adults ◽  
Sleep Disorders ◽  
Older Patients ◽  
Outcome Measure ◽  
Adjustment Disorders ◽  
Main Outcome Measure ◽  
Benzodiazepine Use ◽  
First Time

Background: The purpose of this study was to analyze the prevalence of long-term benzodiazepine use in older adults treated in general and neuropsychiatric practices in Germany. Methods: This study included 32,182 patients over the age of 65 years who received benzodiazepine prescriptions for the first time between January 2010 and December 2014 in general and neuropsychiatric practices in Germany. Follow up lasted until July 2016. The main outcome measure was the proportion of patients treated with benzodiazepines for >6 months. Results: The proportion of patients with benzodiazepine therapy for >6 months increased with age (65–70 years: 12.3%; 71–80 years: 15.5%; 81–90 years: 23.7%; >90 years: 31.6%) but did not differ significantly between men (15.5%) and women (17.1%). The proportion of patients who received benzodiazepines for >6 months was higher among those with sleep disorders (21.1%), depression (20.8%) and dementia (32.1%) than among those with anxiety (15.5%). By contrast, this proportion was lower among people diagnosed with adjustment disorders (7.7%) and back pain (3.8%). Conclusion: Overall, long-term use of benzodiazepines is common in older people, particularly in patients over the age of 80 and in those diagnosed with dementia, sleep disorders, or depression.

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